Daprodustat Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 10, 2024.

Applies to daprodustat: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Increased Risk of Death, Myocardial Infarction, Stroke, Venous Thromboembolism, and Thrombosis of Vascular Access. Daprodustat increases the risk of thrombotic vascular events, including major adverse cardiovascular events (MACE).Targeting a hemoglobin level greater than 11 g/dL is expected to further increase the risk of death and arterial venous thrombotic events, as occurs with erythropoietin stimulating agents (ESAs), which also increase erythropoietin levels.No trial has identified a hemoglobin target level, dose of daprodustat, or dosing strategy that does not increase these risks.Use the lowest dose of daprodustat sufficient to reduce the need for red blood cell transfusions.

Serious side effects of daprodustat

Along with its needed effects, daprodustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking daprodustat:

More common side effects

• blurred vision
• chest tightness
• dizziness
• fever
• headache
• hoarseness
• irritation
• joint pain, stiffness, swelling
• nervousness
• pounding in the ears
• redness of the skin
• slow or fast heartbeat
• swelling of the eyelids, face, lips, hands, or feet
• tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
• trouble breathing
• trouble swallowing

Less common side effects

• blood or black, tarry stools
• chest pain or discomfort
• confusion
• constipation
• difficulty in speaking
• double vision
• inability to move the arms, legs, or facial muscles
• inability to speak
• nausea
• pain or discomfort in the arms, jaws, back, or neck
• sever stomach pain
• slow speech
• sweating
• vomiting
• vomiting of blood material that looks like coffee grounds

Rare side effects

• anxiety
• cough
• dizziness or lightheadedness
• fainting
• pain, redness, or swelling in the arm or leg

Incidence not known

• agitation
• back pain
• coma
• drowsiness
• hallucination
• mood or mental changes
• seizures
• stiff neck
• unusual tiredness or weakness

For healthcare professionals

Applies to daprodustat: oral tablet.

General adverse events

The most common adverse reactions observed in at least 10% of patients treated with this drug were hypertension, thrombotic vascular events, and abdominal pain. Nineteen percent of patients permanently discontinued this drug due to an adverse reaction.

Cardiovascular

• Very common (10% or more): Hypertension (24%)^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (11%)^[Ref]

Abdominal pain included unspecified abdominal pain, upper abdominal pain, abdominal discomfort.^[Ref]

Hematologic

• Common (1% to 10%): Adjudicated thrombotic vascular events (deep vein thrombosis, myocardial infarction, pulmonary embolism, stroke, vascular access thrombosis)^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity^[Ref]

Hypersensitivity included rash, urticaria and dermatitis.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness^[Ref]

Frequently asked questions

• Jesduvroq vs. Aranesp: How do they compare?

Further information

Daprodustat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer