Daprodustat Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 13, 2025.

Applies to daprodustat: oral tablet.

Precautions

It is very important that your doctor check your blood on a regular basis while you are using this medicine. You may also need to monitor your blood pressure at home. If you notice any changes to your recommended blood pressure, call your doctor right away.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use this medicine together with gemfibrozil (Lopid®).

This medicine may increase your risk of having heart attack, stroke, or blood clots. Check with your doctor right away if you have chest pain or discomfort, confusion, difficulty in speaking, double vision, headache, inability to move the arms, legs, or facial muscles, inability to speak, nausea, pain in chest, groin, or legs, especially the calves, pain or discomfort in the arms, jaw, back, or neck, slow speech, sudden, severe weakness or numbness in the arm or leg, sudden loss of coordination, sweating, trouble breathing, or vomiting.

This medicine may increase your risk of hospitalization for heart failure. Check with your doctor right away if you have chest pain or tightness, decreased urine output, dilated neck veins, extreme fatigue, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain.

Call your doctor right away if you have blurred vision, dizziness, nervousness, headache, pounding in the ears, or slow or fast heartbeat. These may be symptoms of high blood pressure.

This medicine may increase your risk of serious stomach or bowel problems (eg, damage to the stomach lining, esophagus, and intestines). This risk may increase if you have a history of stomach or bowel problems (eg, gastrointestinal erosion), use certain medicines, or currently smoke tobacco or drink alcohol. Check with your doctor right away if you have bloody or black, tarry stools, chest pain, constipation, severe stomach pain, throat pain, trouble swallowing, or vomiting of blood or material that looks like coffee grounds.

This medicine may cause cancer. If you are concerned about this, talk with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of daprodustat

Along with its needed effects, daprodustat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking daprodustat:

For healthcare professionals

Applies to daprodustat: oral tablet.

General adverse events

The most common adverse reactions observed in at least 10% of patients treated with this drug were hypertension, thrombotic vascular events, and abdominal pain. Nineteen percent of patients permanently discontinued this drug due to an adverse reaction.

Cardiovascular

• Very common (10% or more): Hypertension (24%)^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (11%)^[Ref]

Abdominal pain included unspecified abdominal pain, upper abdominal pain, abdominal discomfort.^[Ref]

Hematologic

• Common (1% to 10%): Adjudicated thrombotic vascular events (deep vein thrombosis, myocardial infarction, pulmonary embolism, stroke, vascular access thrombosis)^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity^[Ref]

Hypersensitivity included rash, urticaria and dermatitis.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness^[Ref]

See also:

Frequently asked questions

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Further information

Daprodustat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer