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Daclizumab Side Effects

In Summary

Commonly reported side effects of daclizumab include: antibody development and hyperglycemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to daclizumab: subcutaneous solution

Along with its needed effects, daclizumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking daclizumab:

More common
  • Bladder pain
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloody or cloudy urine
  • body aches or pain
  • cough or hoarseness
  • cracked, dry, or scaly skin
  • difficult, burning, or painful urination
  • difficulty with breathing
  • discouragement
  • ear congestion
  • feeling sad or empty
  • fever or chills
  • frequent urge to urinate
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • rash
  • runny nose
  • sneezing
  • sore throat
  • swelling
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness or weakness
Less common
  • Dark urine
  • general feeling of tiredness or weakness
  • light-colored stools
  • persistent loss of appetite
  • right upper quadrant tenderness
  • stomach pain, continuous
  • vomiting
  • yellow eyes or skin
Rare
  • Thoughts or attempts at killing oneself
  • watery or bloody diarrhea
Incidence not known
  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest

Some side effects of daclizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to daclizumab: intravenous solution, subcutaneous solution

Cardiovascular

Common (1% to 10%): Lymphadenopathy, lymphadenitis[Ref]

Dermatologic

Very common (10% or more): Rash (i.e., erythematous rash, exfoliative rash, macular rash, maculopapular rash, papular rash, pruritic rash, rash, vesicular rash) (11%)
Common (1% to 10%): Dermatitis (i.e., allergic dermatitis, atopic dermatitis, bullous dermatitis, dermatitis, exfoliative dermatitis, seborrheic dermatitis, eczema, allergic dermatitis), folliculitis, acne, psoriasis, erythema, pruritus, dry skin
Uncommon (0.1% to 1%): Toxic skin eruption, eczema nummular[Ref]

Gastrointestinal

Common (1% to 10%): Tonsillitis, diarrhea
Frequency not reported: Colitis[Ref]

Hematologic

Common (1% to 10%): Anemia, lymphocyte count decreased[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis (25%), upper respiratory tract infection (17%)
Common (1% to 10%): Bronchitis, pneumonia, laryngitis, rhinitis[Ref]

Psychiatric

Common (1% to 10%): Depression[Ref]

Other

Common (1% to 10%): Oropharyngeal pain, pyrexia[Ref]

Hepatic

Common (1% to 10%): ALT increased, AST increased, liver function test abnormal, hepatic enzymes increased[Ref]

Immunologic

Common (1% to 10%): Influenza, viral infection[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Zinbryta (daclizumab)." AbbVie US LLC, North Chicago, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer

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