Skip to main content

Cortrosyn Side Effects

Generic name: cosyntropin

Note: This document contains side effect information about cosyntropin. Some dosage forms listed on this page may not apply to the brand name Cortrosyn.

Applies to cosyntropin: injectable powder for injection.


Before you receive cosyntropin, tell your doctor about all your medical conditions or allergies, and all the medicines you are using.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have redness, swelling, or hives where the medicine was injected.

Common side effects may include:

  • an allergic reaction;

  • fast or slow heartbeats;

  • increased blood pressure;

  • rash; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to cosyntropin: injectable powder for injection, intravenous solution.


The following adverse reactions have been reported: anaphylaxis, bradycardia, tachycardia, hypertension, peripheral edema, and rash. With long-term use, side effects related to glucocorticoid and mineralocorticoid effects may occur.[Ref]


Postmarketing reports: Anaphylaxis, hypersensitivity reactions[Ref]

Severe anaphylactic reactions have been reported, including fatalities. Most severe reactions have occurred in patients with a history of asthma or other forms of allergy, although in rare instances, has occurred in patients without a history of allergy. Reactions generally manifest within 30 minutes of administration.[Ref]


Postmarketing reports: Bradycardia, tachycardia, hypertension, peripheral edema[Ref]


Postmarketing reports: Rash[Ref]


Isolated cases of adrenal hemorrhage have been reported.[Ref]

Frequency not reported: Adrenal hemorrhage[Ref]


1. "Product Information. Cosyntropin (cosyntropin)." Sandoz Inc (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.