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Clinda-Derm Side Effects

Generic Name: clindamycin topical

Note: This page contains information about the side effects of clindamycin topical. Some of the dosage forms included on this document may not apply to the brand name Clinda-Derm.

For the Consumer

Applies to clindamycin topical: vaginal cream, vaginal suppository

In addition to its needed effects, some unwanted effects may be caused by clindamycin topical (the active ingredient contained in Clinda-Derm). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking clindamycin topical, check with your doctor or nurse as soon as possible:

More common:
  • Itching of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with mild odor
Less common:
  • Diarrhea
  • dizziness
  • headache
  • nausea or vomiting
  • stomach pain or cramps
Rare
  • Burning, itching, rash, redness, swelling or other signs of skin problems not present before use of this medicine

Side Effects: Post Treatment

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

  • Itching of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with mild odor

For Healthcare Professionals

Applies to clindamycin topical: topical foam, topical gel, topical kit, topical lotion, topical solution, topical swab, vaginal cream, vaginal suppository

Dermatologic

Lotion:
Very common (10% or more): Dryness (Up to 18%), erythema (Up to 14%), itching (Up to 11%), oiliness/oily skin (Up to 10%)
Common (1% to 10%): Seborrhea, skin problems, peeling, skin irritation, urticaria
Frequency not reported: Gram-negative folliculitis/folliculitis, contact dermatitis
Postmarketing reports: Rash, pruritus, blisters, papular pruritic skin rash, hair loss, skin inflammation, scaling, skin discoloration

Topical Gel:
Very common (10% or more): Dryness (Up to 23%), oiliness/oily skin (Up to 18%), itching (Up to 10%)
Common (1% to 10%): Erythema
Frequency not reported: Acne aggravated, erythema, scaly rash, skin disorder, gram-negative folliculitis, contact dermatitis

Topical Solution:
Very common (10% or more): Skin dryness (Up to 19%), erythema (Up to 16%), peeling (Up to 11%)
Common (1% to 10%): Skin oiliness/oily skin, skin problems, itching, irritation, urticaria
Frequency not reported: Gram-negative folliculitis, contact dermatitis

Vaginal Cream:
Frequency not reported: Rash, exanthema, urticaria, skin candida, pruritus (non-application site), rash macular, erythema, maculopapular rash[Ref]

Genitourinary

Lotion:
Common (1% to 10%): Urinary tract infection
Postmarketing reports: Fertility disorders, bladder infection

Topical Solution:
Common (1% to 10%): Vaginitis

Vaginal Cream:
Very common (10% or more): Cervicitis/vaginitis (Up to 14%), vulvovaginal moniliasis/candidiasis (Up to 13.3%)
Common (1% to 10%): Vulvovaginal irritation/disorder/pain, vulvovaginitis trichomonal, Candida infection
Frequency not reported: Urinary tract/vaginal infection, menstrual disorder, metrorrhagia, vaginal discharge, endometriosis, proteinuria, dysuria
Postmarketing reports: Pelvic pain

Vaginal Suppository:
Common (1% to 10%): Vulvovaginal disorder, vaginal pain, vaginal moniliasis
Frequency not reported: Menstrual disorder, dysuria, vaginal discharge, vaginitis/vaginal infection[Ref]

Vulvovaginal candidiasis, fungal infection, dysuria, and proteinuria occurred more frequently in pregnant patients given this drug compared to placebo for 7 days.[Ref]

Local

Lotion:
Very common (10% or more): Application site burning/itching (Up to 11%)

Topical Gel:
Frequency not reported: Application site burning/dryness/erythema

Vaginal Cream:
Frequency not reported: Pruritus (topical application site)[Ref]

Gastrointestinal

Lotion:
Common (1% to 10%): Diarrhea
Uncommon (0.1% to 1%): Vomiting
Frequency not reported: Abdominal pain, gastrointestinal disturbances
Postmarketing reports: Nausea, acute colitis, bloating, constipation, colored tongue, dyspepsia, flatulence, gastrointestinal distress/reflux, heartburn, pseudomembranous colitis, rectal bleeding

Topical Gel:
Frequency not reported: Abdominal pain, gastrointestinal disturbances, diarrhea, bloody diarrhea (including pseudomembranous colitis)

Topical Solution:
Common (1% to 10%): Diarrhea, vomiting, nausea, abdominal cramps/pain
Uncommon (0.1% to 1%): Gastrointestinal disturbances
Frequency not reported: Bloody diarrhea (including pseudomembranous colitis)

Vaginal Cream:
Frequency not reported: Heartburn, nausea, vomiting, diarrhea, constipation, localized/generalized abdominal pain, abdominal cramps, breath odor/halitosis, dyspepsia, flatulence, gastrointestinal disorder
Postmarketing reports: Pseudomembranous colitis, abdominal distension

Vaginal Suppository:
Frequency not reported: Abdominal cramps, localized/general abdominal pain[Ref]

Nervous system

Lotion:
Very common (10% or more): Burning sensation (Up to 11%)
Postmarketing reports: Headache, dizziness, facial numbness, metallic taste, voice loss

Topical Gel:
Very common (10% or more): Burning sensation (up to 10%)

Topical Solution:
Very common (10% or more): Burning sensation (Up to 11%)

Vaginal Cream:
Frequency not reported: Dizziness, headache, vertigo, taste perversion[Ref]

Other

Abnormal labor occurred in 1.1% of pregnant patients (in their second trimester) compared to 0% of patients given placebo for 7 days.

Fungal infections occurred in 1.7% of pregnant patients (in their second trimester) compared to 0% of patients given placebo for 7 days.[Ref]

Lotion:
Common (1% to 10%): Dental procedure
Postmarketing reports: Facial swelling, fungal infection

Topical Gel:
Frequency not reported: Smarting

Topical Solution:
Common (1% to 10%): Dental procedure

Vaginal Cream:
Common (1% to 10%): Abnormal labor, fungal infection
Frequency not reported: Bacterial infection, inflammation, microbiology test abnormal, candida infection/moniliasis (body), inflammatory swelling
Postmarketing reports: Pain

Vaginal Suppository:
Common (1% to 10%): Fungal infection[Ref]

Respiratory

Lotion:
Common (1% to 10%): Sore throat/tonsillitis/laryngitis
Uncommon (0.1% to 1%): Upper respiratory tract infection/cough/tracheitis
Postmarketing reports: Epistaxis

Topical Solution:
Common (1% to 10%): Sinusitis/congestion

Vaginal Cream:
Frequency not reported: Epistaxis, upper respiratory tract infection[Ref]

Musculoskeletal

Lotion:
Uncommon (0.1% to 1%): Fracture

Topical Solution:
Common (1% to 10%): Fracture

Vaginal Cream:
Postmarketing reports: Back pain

Vaginal Suppository:
Frequency not reported: Flank pain[Ref]

Immunologic

Lotion:
Common (1% to 10%): Cold/flu

Vaginal Cream:
Frequency not reported: Hypersensitivity[Ref]

Ocular

Lotion:
Frequency not reported: Stinging of the eye, eye pain
Postmarketing reports: Eye irritation

Topical Gel:
Frequency not reported: Eye pain

Topical Solution:
Frequency not reported: Stinging of the eye, eye pain[Ref]

Cardiovascular

Lotion:
Postmarketing reports: Edema, rapid heartbeat, chest tightness

Topical Solution:
Frequency not reported: Sensation of warmth[Ref]

Renal

Vaginal Cream:
Frequency not reported: Glycosuria

Vaginal Suppository:
Frequency not reported: Pyelonephritis[Ref]

Hypersensitivity

Lotion:
Postmarketing reports: Allergic reaction

Vaginal Cream:
Frequency not reported: Allergic reaction[Ref]

Metabolic

Lotion:
Postmarketing reports: Weight loss

Vaginal Cream:
Frequency not reported: Hyperthyroidism[Ref]

Hematologic

Lotion:
Postmarketing reports: Leukopenia[Ref]

Hepatic

Topical Gel:
Postmarketing reports: Elevated liver enzymes[Ref]

References

1. "Product Information. Cleocin vaginal cream (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.

2. "Product Information. Cleocin T (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Cleocin Vaginal Ovules (clindamycin topical)" Pharmacia and Upjohn, Kalamazoo, MI.

5. "Product Information. Clindesse (clindamycin topical)." Ther-Rx Corporation, Bridgeton, MO.

6. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

7. "Product Information. Evoclin (clindamycin topical)." Connetics Inc, Palo Alto, CA.

Not all side effects for Clinda-Derm may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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