Skip to main content


Generic name: clindamycin topicalklin-da-MYE-sin ]
Drug class: Topical acne agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 14, 2021.

What is Evoclin?

Evoclin is an antibiotic foam. Clindamycin prevents bacteria from growing on the skin.

Evoclin foam is used to treat severe acne in adults and children who are at least 12 years old.

Evoclin may also be used for purposes not listed in this medication guide.


You should not use Evoclin if you have ulcerative colitis or enteritis (inflammation of your intestines), or if you have ever had severe diarrhea caused by antibiotic medicine.

It may take up several weeks before your symptoms improve. Keep using Evoclin as directed and tell your doctor if your symptoms do not improve or if they get worse.

Although the risk of serious side effects is low when clindamycin is applied to the skin, side effects can occur if the medication is absorbed into your bloodstream.

Before taking this medicine

You should not use Evoclin if you are allergic to clindamycin or lincomycin, or if you have:

  • inflammation of your intestines (also called enteritis);

  • ulcerative colitis; or

  • if you have ever had severe diarrhea caused by antibiotic medicine.

Tell your doctor if you have ever had:

  • eczema or other skin problems; or

  • an intestinal disorder.

Evoclin is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks. If you are breastfeeding, tell your doctor if you notice diaper rash, diarrhea, or signs of stomach pain in the nursing baby.

If you apply Evoclin foam to your chest, avoid areas that may come into contact with the baby's mouth.

Do not use Evoclin foam on a child younger than 12 years old without the advice of a doctor.

How should I use Evoclin?

Use Evoclin Foam exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Evoclin is usually applied once per day. Follow your doctor's instructions.

Wash your hands before and after applying this medication.

Wash your face with a mild soap or cleanser and pat the skin dry with a clean towel.

Do not dispense Evoclin foam directly onto your hands or face, as the foam will begin to melt on contact with warm skin. Dispense Evoclin foam into the clear cap or onto a cool surface. Pick up small amounts of foam with your fingertips and gently rub the foam into the affected area until the foam disappears.

Avoid getting this medication in your eyes. If it does get into your eyes, rinse thoroughly with water.

It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse.

If you need surgery, tell the surgeon ahead of time that you are using Evoclin. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

Keep the Evoclin foam canister away from an open flame or high heat. Do not puncture the canister or throw an empty canister into a fire.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms include bloody or watery diarrhea, which may result if you absorb this medicine through your skin by applying too much.

What to avoid

Do not smoke while using Evoclin topical foam, or immediately after applying it. The contents of the foam canister are flammable.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Rinse with water if this medicine gets in your eyes or mouth.

Do not use other medicated skin products unless your doctor has told you to. Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Evoclin side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Evoclin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious side effects are unlikely when clindamycin is applied to the skin, but can occur if the medicine is absorbed into your bloodstream.

Stop using Evoclin and call your doctor at once if you have:

  • severe redness, itching, or dryness of treated skin areas; or

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common Evoclin side effects may include:

  • burning, itching, dryness, peeling or redness of treated skin; or

  • oily skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Evoclin?

Tell your doctor about all your other medicines, especially:

  • erythromycin (taken by mouth or applied to the skin).

This list is not complete. Other drugs may affect clindamycin topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share Evoclin with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.