Cefiderocol Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 7, 2020.
For the Consumer
Applies to cefiderocol: intravenous solution reconstituted
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
- Feeling confused.
- Trouble controlling body movements.
- Extra muscle action.
- Redness or white patches in mouth or throat.
- Diarrhea is common with antibiotics. Rarely, a severe form called C diff–associated diarrhea (CDAD) may happen. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen during or a few months after taking antibiotics. Call your doctor right away if you have stomach pain, cramps, or very loose, watery, or bloody stools. Check with your doctor before treating diarrhea.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to cefiderocol: intravenous powder for injection
Very common (10% or more): Elevated liver tests (including increased ALT, increased AST, increased GGT, increased blood alkaline phosphatase, increased hepatic enzyme, increased liver function test, abnormal liver function test, increased transaminases, hypertransaminasemia; up to 16%)
Common (1% to 10%): Increased ALT, increased GGT, increased AST, abnormal hepatic function (including increased liver function test, increased hepatic enzyme, increased transaminases, abnormal liver function test)
Very common (10% or more): Hypokalemia (including decreased blood potassium; up to 11%)
Common (1% to 10%): Hypomagnesemia
Common (1% to 10%): Atrial fibrillation
Common (1% to 10%): Rash (including macular rash, maculopapular rash, erythema, skin irritation, erythematous rash, drug eruption)
Frequency not reported: Pruritus
Beta-lactam antibacterial drugs:
-Frequency not reported: Serious skin reactions[Ref]
Common (1% to 10%): Headache
Frequency not reported: Dysgeusia, seizure
Common (1% to 10%): Candidiasis (including oral candidiasis, vulvovaginal candidiasis, candiduria, candida infection)
Common (1% to 10%): Cough
Uncommon (0.1% to 1%): Hypersensitivity (including skin reactions, pruritus)
Frequency not reported: Drug hypersensitivity
Beta-lactam antibacterial drugs:
-Frequency not reported: Serious and sometimes fatal hypersensitivity (anaphylactic) reactions[Ref]
Frequency not reported: Acute interstitial nephritis
Frequency not reported: RBC urine positive[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Fetroja (cefiderocol)." Shionogi USA Inc, Florham Park, NJ.
More about cefiderocol
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: fourth generation cephalosporins
- Other brands
Related treatment guides
Some side effects may not be reported. You may report them to the FDA.