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Cardoxin Side Effects

Generic Name: digoxin

Note: This page contains information about the side effects of digoxin. Some of the dosage forms included on this document may not apply to the brand name Cardoxin.

For the Consumer

Applies to digoxin: oral capsule liquid filled, oral elixir, oral solution, oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by digoxin (the active ingredient contained in Cardoxin). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking digoxin:

More common:
  • Dizziness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • slow heartbeat
Rare
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • bloody vomit
  • pinpoint red spots on the skin
  • rash with flat lesions or small raised lesions on the skin
  • severe stomach pain
  • unusual bleeding or bruising
Incidence not known:
  • Chest pain or discomfort
  • nausea
  • shortness of breath
  • sweating
  • swelling of the feet and lower legs
  • troubled breathing
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with digoxin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Agitation or combativeness
  • anxiety
  • confusion
  • depression
  • diarrhea
  • expressed fear of impending death
  • hallucinations
  • rash
  • vomiting
Incidence not known:
  • Blurred or loss of vision
  • disturbed color perception
  • double vision
  • halos around lights
  • headache
  • lack of feeling or emotion
  • loss of appetite
  • night blindness
  • overbright appearance of lights
  • swelling of the breasts or breast soreness in both females and males
  • tunnel vision
  • weakness
  • weight loss

For Healthcare Professionals

Applies to digoxin: compounding powder, injectable solution, oral capsule, oral elixir, oral tablet

General

Overall incidence of adverse reactions with this drug has been reported to be 5% to 20%, with 15% to 20% of adverse events considered serious. Cardiac toxicity accounts for about one-half, gastrointestinal disturbances for about one-fourth, and CNS and other toxicity for about one-fourth of these adverse events.[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia, conduction disturbances, bigeminy, trigeminy, PR prolongation, sinus bradycardia
Postmarketing reports: Supraventricular tachyarrhythmia, atrial tachycardia, nodal tachycardia, ventricular arrhythmia, ventricular premature contraction, ST segment depression, atrioventricular block, ventricular fibrillation[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, lower stomach pain
Frequency not reported: Intestinal ischemia, intestinal hemorrhagic necrosis[Ref]

Nervous system

Common (1% to 10%): Central nervous system (CNS) disturbances, dizziness, drowsiness, headache[Ref]

Other

Common (1% to 10%): Central nervous system (CNS) disturbances, dizziness, drowsiness, headache[Ref]

Dermatologic

Common (1% to 10%): Skin rashes of urticarial or scarlatiniform character
Frequency not reported: Maculopapular rash[Ref]

Metabolic

Common (1% to 10%): Anorexia or loss of appetite[Ref]

Ocular

Common (1% to 10%): Blurred vision or visual disturbances[Ref]

Psychiatric

Uncommon (0.1% to 1%): Depression
Frequency not reported: Apathy, confusion, anxiety, delirium, hallucination
Postmarketing reports: Psychosis[Ref]

Hematologic

Frequency not reported: Thrombocytopenia[Ref]

References

1. "Product Information. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Cardoxin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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