Capmatinib Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 23, 2025.

Applies to capmatinib: oral tablet.

Serious side effects of capmatinib

Along with its needed effects, capmatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking capmatinib:

More common side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• chest pain or tightness
• chills
• clay colored stools
• cough
• dark urine
• decreased or loss of appetite
• difficult or labored breathing
• fever
• general feeling of discomfort or illness
• headache
• itching
• nausea and vomiting
• rapid weight gain
• skin rash
• stomach pain or tenderness
• swelling of the feet or lower legs
• thickening of bronchial secretions
• tingling of the hands or feet
• unusual weight gain or loss
• unusual tiredness or weakness
• yellow eyes or skin

Less common side effects

• agitation
• coma
• confusion
• constipation
• decreased urine output
• depression
• dizziness
• fast heartbeat
• hostility
• indigestion
• irritability
• lethargy
• muscle twitching
• pain, redness, swelling, tenderness, warmth on the skin
• pains in the stomach, side, or abdomen, possibly radiating to the back
• seizures
• sore throat
• stupor
• swelling of the face, ankles, or hands

Incidence not known

• increased sensitivity of the skin to sunlight
• redness or other discoloration of the skin
• severe sunburn

Other side effects of capmatinib

Some side effects of capmatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• back pain
• diarrhea

Less common side effects

• hives or welts

For healthcare professionals

Applies to capmatinib: oral tablet.

Hematologic adverse events

• Very common (10% or more): Lymphocytes decreased (44%), hemoglobin decreased (24%), leukocytes decreased (23%)^[Ref]

Musculoskeletal

• Very common (10% or more): Noncardiac chest pain (e.g., chest discomfort, musculoskeletal chest pain, noncardiac chest pain, chest pain) (15%), back pain (14%)^[Ref]

Metabolic

• Very common (10% or more): Albumin decreased (68%), creatinine increased (62%), alanine aminotransferase increased (37%), alkaline phosphatase increased (32%), amylase increased (31%), gamma-glutamyltransferase increased (29%), lipase increased (26%), aspartate aminotransferase increased (25%), sodium decreased (23%), phosphate decreased (23%), glucose decreased (21%), weight loss (10%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (24%), cough (16%)
• Common (1% to 10%): ILD/pneumonitis^[Ref]

Other

• Very common (10% or more): Peripheral edema (e.g., peripheral swelling, peripheral edema, fluid overload) (52%), fatigue/asthenia (32%), pyrexia/increased body temperature (14%)^[Ref]

Renal

Very common (10% or more):

• Common (1% to 10%): Acute kidney injury (including renal failure)^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus (allergic and generalized), cellulitis, urticaria^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (44%), vomiting (28%), constipation (18%), diarrhea (18%)
• Common (1% to 10%): Acute pancreatitis^[Ref]

Frequently asked questions

• How effective is Tabrecta?

Further information

Capmatinib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer