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Capmatinib Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 15, 2024.

Applies to capmatinib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control during treatment and for at least 1 week after the last dose. Males with female partners who are able to become pregnant should use an effective form of birth control during treatment and for at least 1 week after the last dose. If you think you have become pregnant, tell your doctor right away.

This medicine may cause swelling of the lungs (pneumonitis) or interstitial lung disease. These are life-threatening conditions and require immediate medical attention. The symptoms may be similar to the symptoms from lung cancer. Check with your doctor right away if you have new or worsening cough, fever, or trouble breathing.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, a loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause pancreas problems. Check with your doctor right away if you have bloating, chills, constipation, darkened urine, fast heartbeat, fever, indigestion, loss of appetite, nausea, pains in the stomach, side, or abdomen, possibly radiating to the back, vomiting, or yellow eyes or skin.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen and protective clothing when you are outdoors. Avoid sunlamps and tanning beds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of capmatinib

Along with its needed effects, capmatinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking capmatinib:

More common side effects

  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or tightness
  • chills
  • clay colored stools
  • cough
  • dark urine
  • decreased or loss of appetite
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • headache
  • itching
  • nausea and vomiting
  • rapid weight gain
  • skin rash
  • stomach pain or tenderness
  • swelling of the feet or lower legs
  • thickening of bronchial secretions
  • tingling of the hands or feet
  • unusual weight gain or loss
  • unusual tiredness or weakness
  • yellow eyes or skin

Less common side effects

  • agitation
  • coma
  • confusion
  • constipation
  • decreased urine output
  • depression
  • dizziness
  • fast heartbeat
  • hostility
  • indigestion
  • irritability
  • lethargy
  • muscle twitching
  • pain, redness, swelling, tenderness, warmth on the skin
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • seizures
  • sore throat
  • stupor
  • swelling of the face, ankles, or hands

Incidence not known

  • increased sensitivity of the skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

Other side effects of capmatinib

Some side effects of capmatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

Less common side effects

  • hives or welts

For healthcare professionals

Applies to capmatinib: oral tablet.

Hematologic adverse events

Musculoskeletal

Metabolic

Respiratory

Other

Renal

Very common (10% or more):

Dermatologic

Gastrointestinal

See also:

References

1. (2020) "Product Information. Tabrecta (capmatinib)." Novartis Pharmaceuticals

Frequently asked questions

Further information

Capmatinib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.