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Calaspargase pegol Side Effects

Medically reviewed by Drugs.com. Last updated on April 21, 2020.

For the Consumer

Applies to calaspargase pegol: intravenous solution

Side effects requiring immediate medical attention

Along with its needed effects, calaspargase pegol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking calaspargase pegol:

More common

  • Bloating
  • chills
  • constipation
  • dark urine
  • difficulty breathing
  • fast heartbeat
  • fever
  • indigestion
  • loss of appetite
  • nausea
  • pain in the chest, groin, or legs, especially the calves
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes
  • vomiting
  • yellow eyes or skin

Less common

  • Bleeding gums
  • chest pain or discomfort
  • confusion
  • cough
  • coughing up blood
  • difficulty in swallowing
  • dilated neck veins
  • dizziness
  • extreme tiredness or weakness
  • fainting
  • slow or irregular heartbeat
  • headache
  • increased menstrual flow or vaginal bleeding
  • itching in the genital or other skin areas
  • lightheadedness
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • rapid, shallow breathing
  • red or black, tarry stools
  • red or dark brown urine
  • scaling of the skin
  • sneezing
  • sore throat
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • weight gain

Side effects not requiring immediate medical attention

Some side effects of calaspargase pegol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to calaspargase pegol: intravenous solution

Hematologic

Very common (10% or more): Abnormal clotting (e.g., activated partial thromboplastin time prolonged, blood fibrinogen decreased; diarrhea: colitis, diarrhea, enterocolitis, neutropenic colitis) (14%)

Common (1% to 10%): Embolic/thrombotic events (e.g., device related thrombosis, disseminated intravascular coagulation, embolism, intracardiac thrombus, intracranial venous sinus thrombosis, pulmonary embolism, superior sagittal sinus thrombosis, thrombosis in device, venous thrombosis, venous thrombosis limb), hemorrhage (e.g., disseminated intravascular coagulation, epistaxis, hematoma, hemorrhage intracranial, melena, esophageal ulcer hemorrhage, small intestinal hemorrhage, upper GI hemorrhage)[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity[Ref]

Immunologic

Common (1% to 10%): Sepsis (e.g., bacterial sepsis, sepsis), fungal infection (e.g., fungal infection, hepatic infection fungal, respiratory tract infection fungal, splenic infection fungal, systemic candida)

Frequency not reported: Immunogenicity[Ref]

Hepatic

Very common (10% or more): Elevated transaminase (e.g., alanine aminotransferase increased, aspartate aminotransferase increased, transaminases increased) (52%), bilirubin increased (e.g., bilirubin conjugated increased, blood bilirubin increased) (20%)[Ref]

Respiratory

Common (1% to 10%): Dyspnea (e.g., hypoxia, respiratory failure), pneumonia (e.g., lung infection, pneumonia, pneumonitis)[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia (e.g., atrioventricular block complete, sinus tachycardia, ventricular arrhythmia), cardiac failure (e.g., ejection fraction decreased, left ventricular dysfunction)[Ref]

Gastrointestinal

Very common (10% or more): Pancreatitis (e.g., amylase increased, lipase increased, pancreatic necrosis, pancreatitis, pancreatitis relapsing) (18%)

Common (1% to 10%): Diarrhea[Ref]

References

1. "Product Information. Asparlas (calaspargase pegol)." Servier, Boston, MA.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.