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Azasite Side Effects

Generic name: azithromycin ophthalmic

Medically reviewed by Last updated on Oct 5, 2023.

Note: This document contains side effect information about azithromycin ophthalmic. Some dosage forms listed on this page may not apply to the brand name Azasite.

Applies to azithromycin ophthalmic: ophthalmic solution.

Serious side effects of Azasite

Along with its needed effects, azithromycin ophthalmic (the active ingredient contained in Azasite) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azithromycin ophthalmic:

Less common


Other side effects of Azasite

Some side effects of azithromycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


For Healthcare Professionals

Applies to azithromycin ophthalmic: ophthalmic solution.


Very common (10% or more): Ocular discomfort (pruritus, burning, stinging) upon instillation

Common (1% to 10%): Eye irritation, blurred vision, sticky eye sensation, foreign body sensation upon instillation

Uncommon (0.1% to 1%): Conjunctival hyperemia, lacrimation increased upon instillation, erythema of the eyelid

Frequency not reported: Ocular reactions (burning, irritation upon instillation, contact dermatitis, corneal erosion, dry eye, eye pain, itching, ocular discharge, punctate keratitis, reduced visual acuity)

Postmarketing reports: Conjunctivitis, allergic conjunctivitis, keratitis, eyelid eczema, eyelid edema, eye allergy[Ref]


Uncommon (0.1% to 1%): Hypersensitivity[Ref]


Frequency not reported: Hives/urticaria, rash, facial swelling, periocular swelling

Postmarketing reports: Angioedema[Ref]

Nervous system

Frequency not reported: Dysgeusia[Ref]


Frequency not reported: Nasal congestion, sinusitis[Ref]


1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. AzaSite (azithromycin ophthalmic). Inspire Pharmaceuticals Inc. 2008.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.