Atropine / pralidoxime Side Effects
For the Consumer
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received this medicine.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.
Tell your caregivers right away if you have:
pounding heartbeats or fluttering in your chest;
chest pain spreading to your jaw or shoulder;
painful or difficult urination;
little or no urination;
unusual changes in mood or behavior; or
blurred vision, tunnel vision, eye pain, or seeing halos around lights.
Side effects may be more likely in older adults.
Common side effects may include:
dry eyes, vision changes, increased sensitivity to light;
fast heartbeats, increased blood pressure;
behavior changes, feeling excited or confused;
dry skin, rash; or
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to atropine / pralidoxime: intramuscular solution
In cases of organophosphate poisoning, toxic effects from the poisoning may be difficult to differentiate from adverse reactions to this product.[Ref]
Frequency not reported: Headache, dizziness, tremor, drowsiness, locomotor difficulties, medullary paralysis[Ref]
Frequency not reported: Anhidrosis, maculopapular rash, petechial rash, scarletiniform rash[Ref]
Anhidrosis may produce heat intolerance and impair temperature regulation in hot environments.[Ref]
Hypersensitivity is usually seen as skin rashes, on occasion progressing to exfoliation.[Ref]
Frequency not reported: Decreased renal function, transient elevations in creatinine phosphokinase[Ref]
Frequency not reported: Muscular weakness[Ref]
Frequency not reported: Muscle tightness and pain at the injection site[Ref]
Frequency not reported: Fatigue[Ref]
Frequency not reported: Elevations in SGOT and/or SGPT[Ref]
SGOT and SGPT levels returned to normal in about 2 weeks.[Ref]
Frequency not reported: Hyperventilation[Ref]
More about atropine / pralidoxime
Related treatment guides
1. "Product Information. ATNAA (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.
2. "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.
Some side effects may not be reported. You may report them to the FDA.