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Atropine / pralidoxime Side Effects

For the Consumer

Applies to atropine / pralidoxime: intramuscular solution auto-injector

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad dizziness or passing out.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Very bad headache.
  • Feeling confused.
  • Trouble passing urine.
  • Lowered interest in sex.
  • Change in sex ability.
  • Fast breathing.
  • Not able to pass urine or change in how much urine is passed.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Muscle stiffness.
  • Pain where the shot was given.
  • Dry mouth.
  • Dry nose.
  • Change in eyesight.
  • Dry eyes.
  • If bright lights bother your eyes.
  • Larger pupils.
  • Headache.
  • Dizziness.
  • Flushing.
  • Hard stools (constipation).
  • Belly pain.
  • Swelling of belly.
  • Upset stomach or throwing up.
  • Less sweating.
  • Feeling sleepy.
  • Muscle weakness.
  • Dry skin.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to atropine / pralidoxime: intramuscular solution

Nervous system

Nervous system side effects have included confusion, headache, dizziness, restlessness, tremor, fatigue, locomotor difficulties, delirium followed by hallucinations, depression, and, ultimately medullary paralysis and death.[Ref]

Cardiovascular

Cardiovascular side effects have included flushing, sinus tachycardia, palpitations, premature ventricular contractions, atrial flutter, atrial fibrillation, ventricular flutter, ventricular fibrillation, cardiac syncope, asystole, and myocardial infarction.[Ref]

Gastrointestinal

Gastrointestinal side effects have included dysphagia, paralytic ileus, dryness of the mouth, constipation, abdominal pain, abdominal distention, nausea and vomiting.[Ref]

Ocular

Ocular side effects have included blurred vision, dry eyes, photophobia, and acute angle closure glaucoma.[Ref]

Hypersensitivity

Hypersensitivity side effects have included skin rashes which have progressed to exfoliation. Anaphylactic reaction and laryngospasm are rare.[Ref]

Musculoskeletal

Musculoskeletal side effects have included muscular weakness.[Ref]

Dermatologic

Dermatologic side effects have included maculopapular rash, petechial rash, and scarlatiniform rash. Anhidrosis may produce heat intolerance and impairment of temperature regulation in a hot environment.[Ref]

Genitourinary

Genitourinary side effects have included urinary hesitancy or retention, loss of libido, and impotence.[Ref]

References

1. "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.

Some side effects of atropine / pralidoxime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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