Skip to main content

Arestin Side Effects

Generic name: minocycline topical

Medically reviewed by Last updated on Jan 1, 2023.

Note: This document contains side effect information about minocycline topical. Some dosage forms listed on this page may not apply to the brand name Arestin.

Applies to minocycline topical: subgingival powder. Other dosage forms:

Serious side effects of Arestin

Along with its needed effects, minocycline topical (the active ingredient contained in Arestin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking minocycline topical:

More common

  • Bleeding from the gums
  • chills
  • dental pain
  • fever
  • pain, redness, and swelling in the mouth
  • problems with teeth
  • redness or swelling of the gums
  • toothache

Less common

  • Bad taste in the mouth
  • discharge from the gums
  • foul breath odor
  • painful sores in the mouth
  • problems in the lining of the mouth

Other side effects of Arestin

Some side effects of minocycline topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to minocycline topical: mucous membrane insert, topical foam.


Minocycline topical (the active ingredient contained in Arestin) powder is intended for local application only. Systemic effects from the absorption of small amounts of the drug are unlikely.[Ref]


Other side effects have included headache (9%) and pain (4.3%).[Ref]


Dermatologic side effects have included stomatitis (6.4%), mouth ulceration (5%), and mucous membrane disorder (3.3%).[Ref]


Gastrointestinal side effects have included dyspepsia (4%).[Ref]


Local side effects have included periodontitis (16.3%), tooth disorder (12.3%), tooth caries (9.9%), dental pain (9.9%), gingivitis (9.2%), pharyngitis (4.3%), and dental infection (3.8%).[Ref]


Immunologic side effects have included flu syndrome (5%) and infection (7.6%).[Ref]

More about Arestin (minocycline topical)

Patient resources

Other brands

Amzeeq, Zilxi, Cleeravue-M

Professional resources

Related treatment guides


1. "Product Information. Arestin (minocycline topical)." OraPharma Inc (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.