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Apraclonidine ophthalmic Side Effects

For the Consumer

Applies to apraclonidine ophthalmic: ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by apraclonidine ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking apraclonidine ophthalmic, check with your doctor or nurse as soon as possible:

For 0.5% apraclonidineMore common:
  • Allergic reaction (redness, itching, tearing of eye)
Less common or rare:
  • Blurred vision or change in vision
  • chest pain
  • clumsiness or unsteadiness
  • depression
  • dizziness
  • eye discharge, irritation, or pain
  • irregular heartbeat
  • numbness or tingling in fingers or toes
  • raising of upper eyelid
  • rash around eyes
  • redness of eyelid, or inner lining of eyelid
  • swelling of eye, eyelid, or inner lining of eyelid
  • swelling of face, hands, or feet
  • wheezing or troubled breathing
For 1% apraclonidineLess common or rare:
  • Allergic reaction (redness of eye or inner lining of eyelid, swelling of eyelid, watering of eye)
  • irregular heartbeat

Minor Side Effects

Some of the side effects that can occur with apraclonidine ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

For 0.5% apraclonidineMore common:
  • Dryness of mouth
  • eye discomfort
Less common or rare:
  • Change in taste or smell
  • constipation
  • crusting or scales on eyelid or corner of eye
  • discoloration of white part of eye
  • drowsiness or sleepiness
  • dry nose or eyes
  • general feeling of discomfort or illness
  • headache
  • increased sensitivity of eyes to light
  • muscle aches
  • nausea
  • nervousness
  • paleness of eye or inner lining of eyelid
  • runny nose
  • sore throat
  • tiredness or weakness
  • trouble in sleeping
For 1% apraclonidineMore common:
  • Increase in size of pupil of eye
  • paleness of eye or inner lining of eyelid
  • raising of upper eyelid
Less common or rare:
  • Runny nose

For Healthcare Professionals

Applies to apraclonidine ophthalmic: ophthalmic solution


Very common (10% or more): Conjunctivitis, eye pruritus, ocular hyperemia
Common (1% to 10%): Eyelid edema, dry eye, conjunctival follicles, foreign body sensation in eyes, eyelid margin crusting, increased lacrimation, ocular discomfort
Uncommon (0.1% to 1%): Mydriasis, keratitis, keratopathy, reduced visual acuity, visual impairment , photophobia, blurred vision, corneal erosion, corneal infiltrates, blepharospasm, blepharitis, eyelid ptosis, erythema of eyelid, eye pain, eye lid scales, eye lid retraction, conjunctival vascular disorders, conjunctival edema, eye discharge, eye irritation, corneal staining, conjunctival hemorrhage, eye inflammation, eyelid disorder (upper lid elevation), hypotony of eye, eye disorder (conjunctival blanching)[Ref]


Common (1% to 10%): Dry mouth
Uncommon (0.1% to 1%): Nausea, constipation, diarrhea, vomiting, abdominal pain, stomach discomfort[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia, taste perversion
Uncommon (0.1% to 1%): Dizziness, abnormal coordination, somnolence, vasovagal syncope, paresthesia, irritability
Rare (less than 0.1%): Hypoesthesia
Frequency not reported: Parosmia[Ref]


Uncommon (0.1% to 1%): Chest pain, arrhythmia, vasodilation, palpitations, orthostatic hypotension
Frequency not reported: Chest heaviness or burning
Postmarketing reports: Bradycardia[Ref]


Common (1% to 10%): Rhinitis, nasal dryness
Uncommon (0.1% to 1%): Asthma, dyspnea, rhinorrhea, throat irritation
Rare (less than 0.1%): Increased upper airway secretion, nasal discomfort
Frequency not reported: Shortness of breath[Ref]


Uncommon (0.1% to 1%): Depression, nervousness, insomnia, abnormal dreams[Ref]


Common (1% to 10%): Dermatitis
Uncommon (0.1% to 1%): Contact dermatitis
Rare (less than 0.1%): Hyperhidrosis, pruritus
Frequency not reported: Clammy or sweaty palms[Ref]


Uncommon (0.1% to 1%): Myalgia
Rare (less than 0.1%): Pain in extremity[Ref]


Common (1% to 10%): Asthenia
Uncommon (0.1% to 1%): Face edema, malaise, fatigue, peripheral edema
Rare (less than 0.1%): Feeling hot and cold
Frequency not reported: Body heat sensation[Ref]


The most commonly reported side effects were ocular hyperemia, eye pruritus, increased lacrimation, ocular discomfort, eyelid edema, dry mouth, and abnormal sensation in eye.[Ref]


Uncommon (0.1% to 1%): Decreased libido[Ref]


1. "Product Information. Iopidine (apraclonidine)." Alcon Laboratories Inc, Fort Worth, TX.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for apraclonidine ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.