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Generic name: apraclonidine ophthalmicA-pra-KLON-i-deen-off-THAL-mik ]
Drug class: Ophthalmic glaucoma agents

Medically reviewed by on Jul 3, 2023. Written by Cerner Multum.

What is Iopidine?

Apraclonidine reduces the amount of fluid in the eye, which decreases pressure inside the eye.

Iopidine (for the eyes) is used short term to treat or prevent high pressure inside the eye.

Iopidine may also be used for other purposes not listed in this medication guide.

Iopidine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Iopidine may cause serious side effects. Call your doctor at once if you have:

Common side effects of Iopidine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Do not use Iopidine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

You should not use this medicine if you are allergic to apraclonidine or to clonidine (Catapres).

Do not use Iopidine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure this apraclonidine is safe for you, tell your doctor if you have ever had:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether apraclonidine ophthalmic passes into breast milk or if it could harm a nursing baby. You should not breast-feed on the day you are treated with this medicine.

How should I use Iopidine?

Follow all directions on your prescription label. Do not use Iopidine in larger or smaller amounts or for longer than recommended.

Iopidine is usually given as 1 to 2 drops in each affected eye, 3 times per day. Follow your doctor's dosing instructions very carefully.

Wash your hands before using the eye drops.

To apply the eye drops:

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Apraclonidine may become less effective over time. This medicine is for short-term use only.

To be sure this medicine is helping your condition, your vision may need to be tested. You may not notice any change in your symptoms, but vision tests will help your doctor determine how long to treat you with apraclonidine.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of apraclonidine is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Iopidine?

Iopidine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect Iopidine?

Using this medicine while you are taking other medications that make you sleepy can worsen this effect. Ask your doctor before using apraclonidine if you also take a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with apraclonidine ophthalmic, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.