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Iopidine Side Effects

Generic Name: apraclonidine ophthalmic

Note: This document contains side effect information about apraclonidine ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Iopidine.

For the Consumer

Applies to apraclonidine ophthalmic: ophthalmic solution

Along with its needed effects, apraclonidine ophthalmic (the active ingredient contained in Iopidine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking apraclonidine ophthalmic:

For 0.5% apraclonidineMore common
  • Allergic reaction (redness, itching, tearing of the eye)
Less common
  • Blurred vision or change in vision
  • chest pain
  • clumsiness or unsteadiness
  • depression
  • dizziness
  • eye discharge, irritation, or pain
  • irregular heartbeat
  • numbness or tingling in the fingers or toes
  • raising of the upper eyelid
  • rash around the eyes
  • redness of the eyelid or inner lining of the eyelid
  • swelling of the eye, eyelid, or inner lining of the eyelid
  • swelling of the face, hands, or feet
For 1% apraclonidineLess common
  • Blurred vision
  • diarrhea
  • dry mouth
  • eye redness
  • fainting
  • feeling cold or sleepy
  • irregular heartbeat
  • lightheadedness
  • redness, swelling, or whitening of the eyelids
  • slow heartbeat
  • stomach pain
  • stuff or runny nose
  • swelling of the eyelid
  • trouble sleeping
  • unusual dreams
  • unusual taste in the mouth
  • vomiting
  • watering of eye

Get emergency help immediately if any of the following symptoms of overdose occur while taking apraclonidine ophthalmic:

For 1% apraclonidineSymptoms of overdose
  • Confusion
  • clumsiness
  • drowsiness
  • low body temperature
  • muscle aches
  • muscle weakness
  • shivering
  • sleepiness
  • slow heartbeat
  • tiredness
  • weak or feeble pulse
  • weight gain

Some side effects of apraclonidine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For 0.5% apraclonidineMore common
  • Dryness of the mouth
  • eye discomfort
Less common
  • Change in taste or smell
  • constipation
  • crusting or scales on the eyelid or corner of the eye
  • discoloration of white part of the eye
  • drowsiness or sleepiness
  • dry nose or eyes
  • general feeling of discomfort or illness
  • headache
  • increased sensitivity of the eyes to light
  • muscle aches
  • nausea
  • nervousness
  • paleness of the eye or inner lining of the eyelid
  • runny nose
  • sore throat
  • tiredness or weakness
  • trouble in sleeping
For 1% apraclonidineMore common
  • Increase in size of the pupil of the eye
  • paleness of the eye or inner lining of the eyelid
Less common
  • Runny nose

For Healthcare Professionals

Applies to apraclonidine ophthalmic: ophthalmic solution


Very common (10% or more): Conjunctivitis, eye pruritus, ocular hyperemia
Common (1% to 10%): Eyelid edema, dry eye, conjunctival follicles, foreign body sensation in eyes, eyelid margin crusting, increased lacrimation, ocular discomfort
Uncommon (0.1% to 1%): Mydriasis, keratitis, keratopathy, reduced visual acuity, visual impairment , photophobia, blurred vision, corneal erosion, corneal infiltrates, blepharospasm, blepharitis, eyelid ptosis, erythema of eyelid, eye pain, eye lid scales, eye lid retraction, conjunctival vascular disorders, conjunctival edema, eye discharge, eye irritation, corneal staining, conjunctival hemorrhage, eye inflammation, eyelid disorder (upper lid elevation), hypotony of eye, eye disorder (conjunctival blanching)[Ref]


Common (1% to 10%): Dry mouth
Uncommon (0.1% to 1%): Nausea, constipation, diarrhea, vomiting, abdominal pain, stomach discomfort[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia, taste perversion
Uncommon (0.1% to 1%): Dizziness, abnormal coordination, somnolence, vasovagal syncope, paresthesia, irritability
Rare (less than 0.1%): Hypoesthesia
Frequency not reported: Parosmia[Ref]


Uncommon (0.1% to 1%): Chest pain, arrhythmia, vasodilation, palpitations, orthostatic hypotension
Frequency not reported: Chest heaviness or burning
Postmarketing reports: Bradycardia[Ref]


Common (1% to 10%): Rhinitis, nasal dryness
Uncommon (0.1% to 1%): Asthma, dyspnea, rhinorrhea, throat irritation
Rare (less than 0.1%): Increased upper airway secretion, nasal discomfort
Frequency not reported: Shortness of breath[Ref]


Uncommon (0.1% to 1%): Depression, nervousness, insomnia, abnormal dreams[Ref]


Common (1% to 10%): Dermatitis
Uncommon (0.1% to 1%): Contact dermatitis
Rare (less than 0.1%): Hyperhidrosis, pruritus
Frequency not reported: Clammy or sweaty palms[Ref]


Uncommon (0.1% to 1%): Myalgia
Rare (less than 0.1%): Pain in extremity[Ref]


Common (1% to 10%): Asthenia
Uncommon (0.1% to 1%): Face edema, malaise, fatigue, peripheral edema
Rare (less than 0.1%): Feeling hot and cold
Frequency not reported: Body heat sensation[Ref]


The most commonly reported side effects were ocular hyperemia, eye pruritus, increased lacrimation, ocular discomfort, eyelid edema, dry mouth, and abnormal sensation in eye.[Ref]


Uncommon (0.1% to 1%): Decreased libido[Ref]


1. "Product Information. Iopidine (apraclonidine)." Alcon Laboratories Inc, Fort Worth, TX.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Iopidine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.