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Iopidine Side Effects

Generic name: apraclonidine ophthalmic

Medically reviewed by Last updated on Aug 14, 2023.

Note: This document contains side effect information about apraclonidine ophthalmic. Some dosage forms listed on this page may not apply to the brand name Iopidine.

Applies to apraclonidine ophthalmic: ophthalmic solution.

Serious side effects of Iopidine

Along with its needed effects, apraclonidine ophthalmic (the active ingredient contained in Iopidine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking apraclonidine ophthalmic:

For 0.5% apraclonidine

More common

Less common

For 1% apraclonidine

Less common

Get emergency help immediately if any of the following symptoms of overdose occur while taking apraclonidine ophthalmic:

For 1% apraclonidine

Symptoms of overdose

Other side effects of Iopidine

Some side effects of apraclonidine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For 0.5% apraclonidine

More common

Less common

For 1% apraclonidine

More common

Less common

For Healthcare Professionals

Applies to apraclonidine ophthalmic: ophthalmic solution.


The most commonly reported side effects were hyperemia, pruritus, discomfort, and tearing.[Ref]


Very common (10% or more): Conjunctivitis (up to 23%), eye pruritus (up to 23%), ocular hyperemia/hyperemia (up to 23%), increased lacrimation/tearing (up to 15%), lid edema/eyelid edema (up to 15%), ocular discomfort/discomfort (up to 15%), ocular pruritus/pruritus (up to 15%)

Common (1% to 10%): Blurred vision, conjunctival blanching, conjunctival follicles, dimmed vision, dry eye, eye disorder, eyelid margin crusting, eyelid/lid retraction, mydriasis, ocular blanching, ocular discharge, ocular inflammation

Uncommon (0.1% to 1%): Abnormal vision, blepharitis, blepharoconjunctivitis, conjunctival edema, conjunctival hemorrhage, corneal erosion, corneal infiltrates, corneal staining, eye discharge, eye edema, eye inflammation, eye irritation, eye pain, eyelid/lid disorder/upper lid elevation, eyelid/lid erythema, eyelid/lid scales, hypotony of eye, keratitis, keratopathy, photophobia, punctate keratitis, visual acuity reduced, visual impairment

Frequency not reported: Conjunctival microhemorrhage[Ref]


Very common (10% or more): Dry mouth (up to 15%)

Common (1% to 10%): Constipation, nausea

Uncommon (0.1% to 1%): Abdominal pain, diarrhea, stomach discomfort, throat irritation, vomiting

Frequency not reported: Emesis[Ref]


Very common (10% or more): Abnormal sensation in eye/foreign body sensation (up to 15%)

Common (1% to 10%): Ocular injection

Uncommon (0.1% to 1%): Edema, irritation, pain

Frequency not reported: Burning, hypotony, itching[Ref]


Common (1% to 10%): Asthma, dyspnea, nasal decongestion, nasal dryness/dry nose, parosmia, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Rhinorrhea

Rare (0.01% to 0.1%): Increased upper airway secretion, nasal discomfort

Frequency not reported: Increased pharyngeal secretion, nasal burning, shortness of breath[Ref]

Nervous system

Common (1% to 10%): Abnormal coordination, dizziness, dysgeusia, headache, paresthesia, somnolence, taste perversion

Uncommon (0.1% to 1%): Abnormal dreams, blepharospasm, eyelid ptosis, postural dizziness, vasovagal syncope

Rare (0.01% to 0.1%): Hypoesthesia

Frequency not reported: Dream disturbances, extremity numbness, taste abnormality, vasovagal attack

Postmarketing reports: Syncope[Ref]


Common (1% to 10%): Arrythmia, chest pain, irregular heart rate, peripheral edema

Uncommon (0.1% to 1%): Bradycardia, conjunctival vascular disorders, orthostatic hypotension, palpitations, vasodilation

Frequency not reported: Chest burning, chest heaviness, hypertension, hypotension, orthostatic episode[Ref]

Bradycardia was reported in neonates and infants given after a single dose of the 1% ophthalmic solution.[Ref]


Common (1% to 10%): Contact dermatitis, dermatitis, facial/face edema

Rare (0.01% to 0.1%): Hyperhidrosis, pruritus

Frequency not reported: Clammy palms, pruritus not associated with rash, sweaty palms[Ref]


Lethargy was reported in neonates and infants given after a single dose of the 1% ophthalmic solution.[Ref]

Common (1% to 10%): Asthenia, fatigue, malaise

Rare (0.01% to 0.1%): Feeling cold and hot, feeling hot

Frequency not reported: Body heat sensation, head cold sensation, lethargy[Ref]


Common (1% to 10%): Depression, insomnia, nervousness

Uncommon (0.1% to 1%): Irritability[Ref]


Common (1% to 10%): Myalgia

Rare (0.01% to 0.1%): Extremity pain[Ref]


Uncommon (0.1% to 1%): Eye allergy[Ref]


Uncommon (0.1% to 1%): Decreased libido[Ref]


Frequency not reported: Allergic response, hypersensitivity[Ref]


Frequency not reported: Decreased oxygen saturation[Ref]

Decreased oxygen saturation was reported in neonates and infants given after a single dose of the 1% ophthalmic solution.[Ref]


1. "Product Information. Iopidine (apraclonidine ophthalmic)." Alcon Laboratories Inc

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.