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Apraclonidine Ophthalmic Dosage

Medically reviewed on July 18, 2017.

Applies to the following strengths: 1%; 0.5%

Usual Adult Dose for Glaucoma

0.5% solution: 1 to 2 drops should be instilled in the affected eye(s) 3 times per day

-When used concomitantly with other ophthalmic drugs, an approximate 5 minute interval between instillation of each medication should be followed to prevent washout of the previous dose.
-Patients on maximally tolerated medical therapy who are treated to delay surgery should have frequent follow up examinations and treatment should be discontinued if the intraocular pressure rises significantly.

Uses: Short-term adjunctive therapy in patients on maximally tolerated medical therapy who require additional IOP reduction

Usual Adult Dose for Postoperative Increased Intraocular Pressure

1% solution: 1 drop should be instilled in the scheduled operative eye one hour before initiating anterior segment laser surgery and a second drop should be instilled to the same eye immediately upon completion of the laser surgical procedure

-A separate container should be used for each single-drop dose and discarded after use.

Use: Control or prevent postsurgical elevations in intraocular pressure that occur in patients after argon laser trabeculoplasty, argon laser iridotomy or Nd:YAG posterior capsulotomy.

Renal Dose Adjustments

Chronic renal failure: Use with caution

Liver Dose Adjustments

Hepatic impairment: Close monitoring of cardiovascular status is recommended


Safety and efficacy have not been established in patients younger than 18 years

Consult WARNINGS section for additional precautions.


Hemodialysis: Hemodialysis removes 5% of circulating drug.

Other Comments

Administration advice:
-This drug is for topical ophthalmic use only.

Patient advice:
-To minimize systemic absorption, pressure should be applied to the tear duct for 2 minutes immediately after administration.

Storage requirements:
-Protect from light.
-Do not refrigerate or freeze.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.