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Anti-thymocyte globulin (rabbit) Side Effects

For the Consumer

Applies to anti-thymocyte globulin (rabbit): intravenous powder for solution

Along with its needed effects, anti-thymocyte globulin (rabbit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking anti-thymocyte globulin (rabbit):

More common
  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • blurred vision
  • chest pain
  • chills
  • cloudy or bloody urine
  • cold
  • confusion
  • cough or hoarseness
  • diarrhea
  • dizziness
  • fast heartbeat
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • irregular or slow heartbeat
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • nervousness
  • numbness or tingling around the lips, hands, or feet
  • painful or difficult urination
  • pounding in the ears
  • runny nose
  • shivering
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • troubled breathing
  • unexplained anxiety
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • weakness or heaviness of the legs
Less common
  • Burning feeling in chest or stomach tenderness
  • burning or stinging of the skin
  • indigestion
  • inflammation of joints
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • stomach upset
  • Difficulty swallowing
  • hives, itching, rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Some side effects of anti-thymocyte globulin (rabbit) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • anxiety
  • loss of strength or energy
  • nausea
  • pain
  • swelling of the ankles, feet, and fingers
  • tightness in the chest

For Healthcare Professionals

Applies to anti-thymocyte globulin (rabbit): intravenous powder for injection


General side effects have included chills, fever, infections and pain.[Ref]


Cardiovascular side effects have included hypertension, peripheral edema, tachycardia, pulmonary edema and myocardial infarction.[Ref]


Other side effects have included infections (bacterial, fungal, viral and protozoal), reactivation of infections (particularly cytomegalovirus [CMV]) and sepsis.[Ref]

Nervous system

Nervous system side effects have included headache, malaise, asthenia and dizziness.[Ref]


Hematologic side effects have included leukopenia and thrombocytopenia.[Ref]


Gastrointestinal side effects have included gastrointestinal and oral moniliasis, abdominal pain, nausea, diarrhea and vomiting.[Ref]


Genitourinary side effects have included urinary tract infection and vaginitis.[Ref]


Dermatologic side effects have included herpes simplex infections and rash.[Ref]


Respiratory side effects have included pneumonia, acute respiratory distress syndrome, pulmonary edema and dyspnea.[Ref]


Metabolic side effects have included hyperkalemia.[Ref]


1. "Product Information. Thymoglobulin (anti-thymocyte globulin (rabbit))." Genzyme Corporation, Cambridge, MA.

Some side effects of anti-thymocyte globulin (rabbit) may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.