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Anti-thymocyte globulin (rabbit) Side Effects

Medically reviewed by Last updated on Aug 21, 2023.

Applies to anti-thymocyte globulin (rabbit): intravenous powder for solution.


Intravenous route (Powder for Solution)

Antithymocyte globulin rabbit should only be used by physicians experienced in immunosuppressive therapy in transplantation.

Serious side effects

Along with its needed effects, anti-thymocyte globulin (rabbit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking anti-thymocyte globulin (rabbit):

More common

Less common


Other side effects

Some side effects of anti-thymocyte globulin (rabbit) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to anti-thymocyte globulin (rabbit): intravenous powder for injection.


Very common (10% or more): Hypertension (18%)

Common (1% to 10%): Tachycardia

Frequency not reported: Myocardial infarction, hypotension, reduced oxygen supply to tissues, chest pain[Ref]


Very common (10% or more): Pyrexia (28%), pain (26%)

Frequency not reported: Lethargy, malaise[Ref]

Nervous system

Very common (10% or more): Headache (18%)

Frequency not reported: Dizziness, decreased sensitivity[Ref]


Very common (10% or more): Leukopenia (63%), anemia (25%), thrombocytopenia (16%), neutropenia

Common (1% to 10%): Febrile neutropenia[Ref]


Very common (10% or more): Constipation (33%), vomiting (12%)

Common (1% to 10%): Abdominal pain, diarrhea, moniliasis, gastritis, dysphagia

Frequency not reported: Abdominal tenderness, abdominal discomfort, pain in the mouth and throat[Ref]


Very common (10% or more): Urinary tract infection (42%)[Ref]


Very common (10% or more): Rash (13%), sweating (13%), acne (12%)

Common (1% to 10%): Herpes simplex

Frequency not reported: Pruritus[Ref]


Very common (10% or more): Dyspnea (28%), lower respiratory tract infection (13%), upper respiratory tract infection (11%)

Common (1% to 10%): Nasopharyngitis

Frequency not reported: Cough, throat irritation, shortness of breath, pulmonary edema[Ref]


Common (1% to 10%): Hyperphosphatemia, acidosis, hypokalemia, anorexia[Ref]


Uncommon (0.1% to 1%): Cytokine release syndrome (CRS), anaphylaxis[Ref]


Very common (10% or more): Infection (31%), cytomegaloviral infection (13%), sepsis (12%)

Common (1% to 10%): Herpes zoster, oral candidiasis, sepsis

Uncommon (0.1% to 1%): Serum sickness[Ref]


Uncommon (0.1% to 1%): Infusion related reactions

Frequency not reported: Localized edema[Ref]


Very common (10% or more): Myalgia (20%), arthralgia (15%)

Frequency not reported: Joint pain[Ref]


Very common (10% or more): Insomnia (20%), anxiety (14%)

Frequency not reported: Confusional state, agitation, restlessness[Ref]


Common (1% to 10%): Transaminases increased

Uncommon (0.1% to 1%): Hepatocellular injury, hepatotoxicity, hepatic failure[Ref]


Common (1% to 10%): Malignancy, lymphomas (which may be virally mediated), neoplasms malignant (solid tumors)

Uncommon (0.1% to 1%): Lymphoproliferative disorder[Ref]


1. "Product Information. Thymoglobulin (rabbit) (anti-thymocyte globulin (rabbit))." Genzyme Corporation

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.