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Amphotericin B Lipid Complex Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 31, 2024.

Applies to amphotericin b lipid complex: suspension.

Serious side effects

Along with its needed effects, amphotericin b lipid complex may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amphotericin b lipid complex:

More common side effects

  • chills and fever
  • headache
  • nausea and vomiting

Less common side effects

  • difficulty in breathing
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual tiredness and weakness

Rare side effects

  • increased or decreased urination

Other side effects

Some side effects of amphotericin b lipid complex may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • diarrhea
  • loss of appetite
  • stomach pain

For healthcare professionals

Applies to amphotericin b lipid complex: intravenous suspension.

General adverse events

The most common clinical side effects in clinical trials were chills, increased creatinine, pyrexia, hypokalemia, nausea, and vomiting.[Ref]

Other

Renal

Metabolic

Gastrointestinal

Hematologic

Nervous system

Hypersensitivity

Cardiovascular

Respiratory

Dermatologic

Local

Musculoskeletal

Hepatic

Genitourinary

Ocular

Psychiatric

References

1. Kline S, Larsen TA, Fieber L, Fishbach R, Greenwood M, Harris R, Kline MW, Tennican PO, Janoff EN (1995) "Limited toxicity of prolonged therapy with high doses of amphotericin b lipid complex." Clin Infect Dis, 21, p. 1154-8

2. Oravcova E, Mistrik M, Sakalova A, Drgona L, Kollar T, Helpianska L, Ilavska I, Sorkovska D, Spanik S, Kukuckova E, Krcmery V (1995) "Amphotericin b lipid complex to treat invasive fungal infections in cancer patients: report of efficacy and safety in 20 patients." Chemotherapy, 41, p. 473-6

3. "Product Information. Abelcet (amphotericin B lipid complex)." Liposome Company Inc, The

4. Sharkey PK, Graybill JR, Johnson ES, Hausrath SG, Pollard RB, Kolokathis A, Mildvan D, Fanhavard P, Eng RHK, Patterson TF, (1996) "Amphotericin b lipid complex compared with amphotericin b in the treatment of cryptococcal meningitis in patients with AIDS." Clin Infect Dis, 22, p. 315-21

5. Sundar S, Murray HW (1996) "Cure of antimony-unresponsive indian visceral leishmaniasis with amphotericin b lipid complex." J Infect Dis, 173, p. 762-5

6. Rapp RP, Gubbins PO, Evans ME (1997) "Amphotericin B lipid complex." Ann Pharmacother, 31, p. 1174-86

7. Lopez-Velez R, Videla S, Marquez M, et al. (2004) "Amphotericin B lipid complex versus no treatment in the secondary prophylaxis of visceral leishmaniasis in HIV-infected patients." J Antimicrob Chemother, 53, p. 540-3

8. Cerner Multum, Inc. "UK Summary of Product Characteristics."

9. Cerner Multum, Inc. "Australian Product Information."

10. Sorkin P, Nagar H, Weinbroum A, Setton A, Israitel E, Scarlatt A, Silbiger A, Rudick V, Kluger Y, Halpern P (1996) "Administration of amphotericin b in lipid emulsion decreases nephrotoxicity: results of a prospective, randomized, controlled study in critically ill patients." Crit Care Med, 24, p. 1311-5

11. Gales MA, Gales BJ (1996) "Acute renal failure with amphotericin B in lipid emulsion." Ann Pharmacother, 30, p. 1036

12. Rowles DM, Fraser SL (1999) "Amphotericin B lipid complex (ABLC)-associated hypertension: Case report and review." Clin Infect Dis, 29, p. 1564-5

Further information

Amphotericin b lipid complex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.