Amphotericin B Lipid Complex Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 5, 2024.

Applies to amphotericin b lipid complex: suspension.

Serious side effects

Along with its needed effects, amphotericin b lipid complex may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amphotericin b lipid complex:

Other side effects

Some side effects of amphotericin b lipid complex may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to amphotericin b lipid complex: intravenous suspension.

General adverse events

The most common clinical side effects in clinical trials were chills, increased creatinine, pyrexia, hypokalemia, nausea, and vomiting.^[Ref]

Other

• Very common (10% or more): Chills (up to 18%), fever/pyrexia (up to 14%), multiple organ failure (11%)
• Common (1% to 10%): Sepsis, infection, pain, chest pain, increased alkaline phosphatase
• Frequency not reported: Malaise, weight loss, increased lactate dehydrogenase, shivering, generalized edema, asthenia, peripheral edema

Renal

• Very common (10% or more): Increased serum creatinine (up to 13%)
• Common (1% to 10%): Renal failure, renal impairment, increased BUN/urea
• Frequency not reported: Decreased renal function, abnormal kidney function
• Postmarketing reports: Renal tubular acidosis (including hyposthenuria, electrolyte imbalance [e.g., increased potassium, decreased magnesium]), nephrogenic diabetes insipidus^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, electrolyte imbalance (including increased blood potassium, decreased blood magnesium)
• Frequency not reported: Anorexia, hypomagnesemia, hyperkalemia, hypocalcemia, hypercalcemia, acidosis, hyperamylasemia, hypoglycemia, hyperglycemia, hyperuricemia, hypophosphatemia, hypernatremia, hyponatremia, hyperchloremia
• Postmarketing reports: Hyperammonemia^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, diarrhea, gastrointestinal hemorrhage, abdominal pain, nausea and vomiting
• Frequency not reported: Melena, dyspepsia, epigastric pain, cramping, constipation
• Postmarketing reports: Peritonitis^[Ref]

Hematologic

• Common (1% to 10%): Thrombocytopenia, leukopenia, anemia
• Frequency not reported: Coagulation defects, blood dyscrasias (including eosinophilia), leukocytosis, decreased thromboplastin
• Postmarketing reports: Pancytopenia^[Ref]

Nervous system

• Common (1% to 10%): Headache, tremor
• Uncommon (0.1% to 1%): Convulsions, neuropathy
• Frequency not reported: Peripheral neuropathy, deafness, hearing loss, tinnitus, transient vertigo, cerebral vascular accident, extrapyramidal syndrome, other neurologic symptoms, somnolence
• Postmarketing reports: Encephalopathy, stupor^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Anaphylactic response
• Frequency not reported: Anaphylaxis, allergic reactions (including bronchospasm, wheezing, asthma), anaphylactoid reactions, infusion hypersensitivity reactions (including abdominal pain, nausea, vomiting, myalgia, pruritus, maculopapular rash, fever, hypotension, shock, bronchospasm, respiratory failure)^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension, cardiac arrest, hypertension, tachycardia, cardiac arrhythmias
• Uncommon (0.1% to 1%): Shock
• Frequency not reported: Cardiac failure, myocardial infarction, thrombophlebitis, cardiomyopathy, arrhythmias, ventricular fibrillation, atrial fibrillation, phlebitis, supraventricular tachycardia, abnormal ECG, cyanosis
• Postmarketing reports: Asystole, bradycardia, hemorrhage, vasodilation^[Ref]

Respiratory

• Common (1% to 10%): Respiratory failure, dyspnea, pneumonia, respiratory disorder, asthma
• Frequency not reported: Wheezing, pulmonary edema, hemoptysis, tachypnea, pulmonary embolus, pleural effusion, hypoxia, lung disorder, pneumonia, hyperventilation, increased cough, pharyngitis, apnea
• Postmarketing reports: Bronchospasm^[Ref]

Dermatologic

• Common (1% to 10%): Rash
• Uncommon (0.1% to 1%): Pruritus
• Frequency not reported: Maculopapular rash, erythema multiforme, skin ulcer, exanthema
• Postmarketing reports: Exfoliative dermatitis^[Ref]

Local

• Uncommon (0.1% to 1%): Injection site reaction
• Frequency not reported: Injection site inflammation, injection site hypersensitivity^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myalgia
• Frequency not reported: Myasthenia, bone pain, joint pain, muscle pain^[Ref]

Hepatic

• Common (1% to 10%): Hyperbilirubinemia, abnormal liver function tests
• Frequency not reported: Acute liver failure, jaundice, hepatitis, increased AST, increased ALT, veno-occlusive liver disease, hepatomegaly, cholangitis, cholecystitis, bilirubinemia^[Ref]

Genitourinary

• Frequency not reported: Oliguria, anuria, impotence, dysuria, hematuria, urinary tract infection, pyuria, urinary tract disorder
• Postmarketing reports: Hyposthenuria, incontinence^[Ref]

Ocular

• Frequency not reported: Visual impairment, diplopia

Psychiatric

• Frequency not reported: Confusion, insomnia, anxiety
• Postmarketing reports: Agitation

See also:

Further information

Amphotericin b lipid complex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer