Allogeneic Processed Thymus Tissue Side Effects
Applies to allogeneic processed thymus tissue: intramuscular implant.
General adverse events
The most common adverse reactions reported were hypertension, cytokine release syndrome, rash, hypomagnesemia, renal impairment/failure, thrombocytopenia, and graft versus host disease.[Ref]
Dermatologic
Rash includes rash, granuloma skin, rash popular, urticaria.[Ref]
Gastrointestinal
- Common (1% to 10%): Diarrhea[Ref]
Diarrhea includes diarrhea and hemorrhagic diarrhea.[Ref]
Cardiovascular
- Very common (10% or more): Hypertension (19%)[Ref]
Hematologic
- Very common (10% or more): Thrombocytopenia (12%)
- Common (1% to 10%): Hemolytic anemia, neutropenia[Ref]
Thrombocytopenia includes thrombocytopenia and immune thrombocytopenic purpura.
Hemolytic anemia includes autoimmune hemolytic anemia, Coombs-positive hemolytic anemia, hemolysis, hemolytic anemia.[Ref]
Immunologic
- Very common (10% or more): Cytokine release syndrome (18%), graft versus host disease (10%)[Ref]
Graft versus host disease (GVHD) includes GVHD, GVHD-gut, GVHD-skin, omenn syndrome.[Ref]
Metabolic
- Very common (10% or more): Hypomagnesemia (16%)
- Common (1% to 10%): Acidosis[Ref]
Acidosis includes acidosis and blood bicarbonate decreased.[Ref]
Nervous system
- Common (1% to 10%): Seizure[Ref]
Seizures include infantile spasms, seizures, and febrile convulsion.[Ref]
Other
- Common (1% to 10%): Pyrexia[Ref]
Renal
- Very common (10% or more): Renal impairment/failure (12%)
- Common (1% to 10%): Proteinuria
- Frequency not reported: Acute kidney injury, blood creatinine increased, renal tubular acidosis[Ref]
Respiratory
- Common (1% to 10%): Respiratory distress[Ref]
Respiratory distress includes respiratory distress, hypoxia, respiratory failure.[Ref]
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References
1. (2021) "Product Information. Rethymic (allogeneic processed thymus tissue)." Enzyvant Therapeutics Inc., 1
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Further information
Allogeneic processed thymus tissue side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.