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Actimmune Side Effects

Generic name: interferon gamma-1b

Medically reviewed by Last updated on Oct 23, 2023.

Note: This document contains side effect information about interferon gamma-1b. Some dosage forms listed on this page may not apply to the brand name Actimmune.

Applies to interferon gamma-1b: solution.

Serious side effects of Actimmune

Along with its needed effects, interferon gamma-1b (the active ingredient contained in Actimmune) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking interferon gamma-1b:

More common

Less common

Incidence not known

Other side effects of Actimmune

Some side effects of interferon gamma-1b may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to interferon gamma-1b: subcutaneous solution.


Very common (10% or more): Diarrhea, nausea, vomiting

Common (1% to 10%): Abdominal pain

Frequency not reported: Pancreatitis, GI hemorrhage[Ref]


Very common (10% or more): Rash[Ref]


Very common (10% or more): Injection site pain[Ref]


Frequency not reported: Cardiac failure, myocardial infarction, tachyarrhythmia, atrioventricular block, transient ischemic attack, deep vein thrombosis, hypotension, syncope[Ref]

Nervous system

Very common (10% or more): Headache

Frequency not reported: Convulsions, Parkinsonian gait, Parkinsonian rest tremor, gait disturbance[Ref]


Frequency not reported: Pulmonary embolism, interstitial lung disease, bronchospasm, tachypnea, chest discomfort[Ref]


Frequency not reported: Neutropenia, thrombocytopenia[Ref]


Frequency not reported: Renal failure, proteinuria[Ref]


Frequency not reported: Hyponatremia, hypoglycemia, hypertriglyceridemia[Ref]


Common (1% to 10%): Myalgia, arthralgia, back pain


Common (1% to 10%): Depression

Frequency not reported: Confusion, disorientation, hallucination[Ref]


Very common (10% or more): Hepatic enzymes increased[Ref]


Very common (10% or more): Fever, chills, fatigue[Ref]


1. Product Information. Actimmune (interferon gamma-1b). Horizon Therapeutics USA Inc. 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.