Actimmune Dosage
Generic name: INTERFERON GAMMA-1B 100ug in 0.5mL
Dosage form: injection, solution
Drug class: Interferons
Medically reviewed by Drugs.com. Last updated on Apr 17, 2025.
Dosing Information
- The recommended dosage of ACTIMMUNE administered subcutaneously, for the treatment of patients with CGD and SMO is shown in Table 1 below:
Body Surface Area (m2) | Dose (mcg/m2) | Dose (International Units/m2)* | Frequency |
---|---|---|---|
|
|||
Greater than 0.5 m2 | 50 mcg/m2 | 1 million International Units/m2 | Three times weekly (For example, Monday, Wednesday and Friday) |
Equal to or less than 0.5 m2 | 1.5 mcg/kg/dose | ------------ | Three times weekly (For example, Monday, Wednesday and Friday) |
- Prior to the beginning of treatment and at three-month intervals during treatment the following laboratory tests are recommended for all patients on ACTIMMUNE (interferon gamma-1b) therapy:
- Hematologic tests – including complete blood counts, differential and platelet counts
- Blood chemistries – including renal and liver function tests. In patients less than 1 year of age, liver function tests should be measured monthly.
- Urinalysis
Important Administration Instructions
- The optimum sites of subcutaneous injection are the right and left deltoid and anterior thigh.
- ACTIMMUNE can be administered by a physician, nurse, family member or patient when appropriately counseled in the administration of subcutaneous injections.
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. ACTIMMUNE is a clear, colorless solution.
- ACTIMMUNE is for a single dose only. Discard any unused portion. ACTIMMUNE does not contain a preservative.
- ACTIMMUNE should not be mixed with other drugs in the same syringe.
- Administer ACTIMMUNE using either sterilized glass or plastic disposable syringes.
Dose Modification
- If severe reactions occur, the dosage should be reduced by 50 percent or therapy should be interrupted until the adverse reaction abates.
- Safety and efficacy has not been established for ACTIMMUNE given in doses greater or less than the recommended dose of 50 mcg/m2. Higher doses (i.e., greater than 50 mcg/m2) are not recommended. The minimum effective dose of ACTIMMUNE has not been established.
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Further information
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