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Actimmune Dosage

Generic name: Interferon gamma-1b 100ug in 0.5mL
Dosage form: injection, solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Dosing Information

  • The recommended dosage of ACTIMMUNE administered subcutaneously, for the treatment of patients with CGD and SMO is shown in Table 1 below:
Table 1: Recommended Dosage for ACTIMMUNE for the Treatment of Patients with CGD and SMO
Body Surface Area (m2) Dose (mcg/m2) Dose (International Units/m2)* Frequency
*
Note that the above activity is expressed in International Units (1 million International Units/50 mcg). This is equivalent to what was previously expressed as units (1.5 million units/50 mcg).
Greater than 0.5 m2 50 mcg/m2 1 million International Units/m2 Three times weekly
(For example, Monday, Wednesday and Friday)
Equal to or less than 0.5 m2 1.5 mcg/kg/dose ------------ Three times weekly
(For example, Monday, Wednesday and Friday)
  • Prior to the beginning of treatment and at three-month intervals during treatment the following laboratory tests are recommended for all patients on ACTIMMUNE (interferon gamma-1b) therapy[see Warnings and Precautions (5.3, 5.4, 5.6)]:
    • Hematologic tests – including complete blood counts, differential and platelet counts
    • Blood chemistries – including renal and liver function tests. In patients less than 1 year of age, liver function tests should be measured monthly [see Adverse Reactions (6.2)].
    • Urinalysis

Important Administration Instructions

  • The optimum sites of subcutaneous injection are the right and left deltoid and anterior thigh.
  • ACTIMMUNE can be administered by a physician, nurse, family member or patient when appropriately counseled in the administration of subcutaneous injections.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. ACTIMMUNE is a clear, colorless solution.
  • ACTIMMUNE is for a single use only. Discard any unused portion. ACTIMMUNE does not contain a preservative.
  • ACTIMMUNE should not be mixed with other drugs in the same syringe.
  • Administer ACTIMMUNE using either sterilized glass or plastic disposable syringes.

Dose Modification

  • If severe reactions occur, the dosage should be reduced by 50 percent or therapy should be interrupted until the adverse reaction abates.
  • Safety and efficacy has not been established for ACTIMMUNE given in doses greater or less than the recommended dose of 50 mcg/m2. Higher doses (i.e., greater than 50 mcg/m2) are not recommended. The minimum effective dose of ACTIMMUNE has not been established.
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