Abraxane Side Effects

Generic name: paclitaxel protein-bound

Medically reviewed by Drugs.com. Last updated on May 14, 2023.

Note: This document contains side effect information about paclitaxel protein-bound. Some dosage forms listed on this page may not apply to the brand name Abraxane.

Summary

Common side effects of Abraxane include: infection, severe peripheral sensory neuropathy, bone marrow depression, neutropenia, alopecia, anemia, and peripheral sensory neuropathy. Other side effects include: hypersensitivity reaction. Continue reading for a comprehensive list of adverse effects.

Applies to paclitaxel protein-bound: intravenous powder for suspension.

Warning

Intravenous route (Powder for Suspension)

Severe MyelosuppressionDo not administer paclitaxel protein-bound particles therapy to patients with baseline neutrophil counts less than 1500 cells/mm(3).Monitor for neutropenia, which may be severe and result in infection or sepsis.Perform frequent complete blood cell counts on all patients receiving paclitaxel protein-bound particles.

Serious side effects of Abraxane

Along with its needed effects, paclitaxel protein-bound (the active ingredient contained in Abraxane) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking paclitaxel protein-bound:

More common

Black, tarry stools
bloating or swelling of the face, arms, hands, lower legs, or feet
blurred or double vision
chest pain
chills
cough
fever
loss of taste
lower back or side pain
painful or difficult urination
pale skin
rapid weight gain
sneezing
sore mouth, tongue, or throat
tightness in the chest
tingling of the hands or feet
troubled breathing with exertion
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual weight gain or loss
unusual tiredness or weakness

Less common

Anxiety
bleeding
blood in the urine or stools
burning, tingling, numbness or pain in the hands, arms, feet, or legs
confusion
difficulty with swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast, pounding, slow, or irregular heartbeat or pulse
general feeling of discomfort or illness
inability to move the arms, legs, or facial muscles
inability to speak
pain in the chest, groin, or legs, especially the calves
pinpoint red spots on the skin
rapid, shallow breathing
sensation of pins and needles
severe, sudden headache
skin itching, rash, or redness
slurred or slow speech
stabbing pain
sudden loss of coordination
sudden, severe weakness or numbness in the arms or legs
sudden, unexplained shortness of breath
sweating
swelling of the face, throat, or tongue
thickening of bronchial secretions
trouble thinking or walking

Other side effects of Abraxane

Some side effects of paclitaxel protein-bound may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Cracked lips
decreased appetite
diarrhea
difficulty with moving
headache
lack or loss of strength
loss of hair
muscle pain or stiffness
nausea
pain in the joints
swelling
vomiting

Less common

Bleeding, blistering, burning, coldness, discoloration of the skin, a feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Rare

Nail changes

For Healthcare Professionals

Applies to paclitaxel protein-bound: intravenous powder for injection.

Dermatologic

Very common (10% or more): Alopecia (90%), rash

Common (1% to 10%): Nail disorder, pruritus, dry skin, erythema, nail pigmentation/discoloration, skin hyperpigmentation, onycholysis, nail changes

Uncommon (0.1% to 1%): Nail bed tenderness, urticaria, skin pain, photosensitivity reaction, pigmentation disorder, pruritic rash, skin disorder, hyperhidrosis, onychomadesis, erythematous rash, generalized rash, dermatitis, night sweats, maculopapular rash, vitiligo, hypotrichosis, nail discomfort, generalized pruritus, macular rash, papular rash, skin lesion, swollen face

Very rare (less than 0.01%): Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)^[Ref]

Hematologic

Very common (10% or more): Neutropenia (up to 82%), anemia (up to 25%), leukopenia, thrombocytopenia, lymphopenia, bone marrow suppression

Common (1% to 10%): Febrile neutropenia

Rare (less than 0.1%): Pancytopenia^[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy, neuropathy, hypoesthesia, paresthesia

Common (1% to 10%): Peripheral sensory neuropathy, headache, dysgeusia, dizziness, peripheral motor neuropathy, ataxia, sensory disturbance, somnolence

Uncommon (0.1% to 1%): Polyneuropathy, areflexia, dyskinesia, hyporeflexia, neuralgia, sensory loss, syncope, postural dizziness, neuropathic pain, tremor, abnormal gait^[Ref]

Cardiovascular

Very common (10% or more): Abnormal ECG (60%) including abnormal ECG in patients with a normal baseline (35%)

Common (1% to 10%): Tachycardia, arrhythmia, supraventricular tachycardia, flushing, hot flushes, hypertension, lymphedema, peripheral edema, chest pain

Uncommon (0.1% to 1%): Hypotension, peripheral coldness, orthostatic hypotension, chest discomfort, increased blood pressure

Rare (less than 0.1%): Bradycardia, cardiac arrest, left ventricular dysfunction, congestive heart failure, atrioventricular block, thrombosis^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia/myalgia (44%)

Common (1% to 10%): Pain in extremity, bone pain, back pain, muscle cramps, limb pain, rigors

Uncommon (0.1% to 1%): Chest wall pain, muscular weakness, neck pain, groin pain, muscle spasms, musculoskeletal pain, flank pain, limb discomfort, muscle weakness^[Ref]

Hepatic

Very common (10% or more): AST (SGOT) elevations (39%), alkaline phosphatase elevations (36%), gamma-glutamyl transpeptidase (GGT) elevations (14%) patients

Common (1% to 10%): Bilirubin elevations

Uncommon (0.1% to 1%): Hepatomegaly

Rare (less than 0.1%): Hepatic necrosis, hepatic encephalopathy^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (30%), diarrhea (26%), vomiting (18%), constipation, stomatitis

Common (1% to 10%): Abdominal pain, abdominal distension, upper abdominal pain, dyspepsia, gastroesophageal reflux disease, oral hypoesthesia, mucosal inflammation

Uncommon (0.1% to 1%): Dysphagia, flatulence, glossodynia, dry mouth, gingival pain, esophagitis, lower abdominal pain, mouth ulceration, oral pain, rectal hemorrhage

Rare (less than 0.1%): Intestinal obstruction, intestinal perforation, pancreatitis, ischemic colitis, neutropenic enterocolitis^[Ref]

Other

Very common (10% or more): Fatigue, asthenia, pyrexia

Common (1% to 10%): Vertigo, pain, edema, weakness, decreased performance status, malaise, lethargy, hyperpyrexia

Uncommon (0.1% to 1%): Ear pain, tinnitus^[Ref]

Respiratory

Common (1% to 10%): Upper respiratory tract infection, sinusitis, interstitial pneumonitis, dyspnea, epistaxis, pharyngolaryngeal pain, cough, rhinitis, rhinorrhea

Uncommon (0.1% to 1%): Nasopharyngitis, pneumonia, productive cough, exertional dyspnea, sinus congestion, decreased breath sounds, pleural effusion, allergic rhinitis, hoarseness, nasal congestion, nasal dryness, wheezing, pulmonary emboli, pulmonary thromboembolism^[Ref]

Hypersensitivity

Very common (10% or more): Hypersensitivity (up to 12%)

Rare (less than 0.1%): Severe hypersensitivity^[Ref]

Local

Uncommon (0.1% to 1%): Swelling, injection site reaction

Rare (0.01% to 0.1%): Extravasation^[Ref]

Ocular

Common (1% to 10%): Increased lacrimation, blurred vision, dry eye, keratoconjunctivitis sicca, madarosis

Uncommon (0.1% to 1%): Eye irritation, eye pain, abnormal vision, reduced visual acuity, conjunctivitis, visual disturbance, eye pruritus, keratitis

Rare (less than 0.1%): Cystoid macular edema^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Dysuria, pollakiuria, hematuria, nocturia, polyuria, urinary incontinence, breast pain^[Ref]

Metabolic

Very common (10% or more): Anorexia

Common (1% to 10%): Dehydration, hypokalemia, weight loss, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyltransferase, decreased hematocrit, decreased red blood cell count, increased blood alkaline phosphatase

Uncommon (0.1% to 1%): Hypophosphatasemia, fluid retention, hypoalbuminemia, polydipsia, hyperglycemia, hypocalcemia, hypoglycemia, hyponatremia, weight gain, increased blood lactate dehydrogenase, increased blood creatinine, increased blood glucose, increased blood phosphorus, decreased blood potassium, increased bilirubin^[Ref]

Oncologic

Uncommon (0.1% to 1%): Metastatic pain, tumor necrosis^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, depression, anxiety

Uncommon (0.1% to 1%): Restlessness^[Ref]

Immunologic

Very common (10% or more): Infections (up to 24%)

Common (1% to 10%): Febrile neutropenia, folliculitis, candidiasis, influenza-like illness

Uncommon (0.1% to 1%): Neutropenic sepsis, oral candidiasis, cellulitis, herpes simplex, viral infection, catheter-related infection, fungal infection, herpes zoster, injection site infection, sepsis, neutropenic sepsis^[Ref]