...gain. If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Actoplus Met. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have...
...orally once a day Duration of therapy: Until disease progression or unacceptable toxicity Use: For the treatment of patients with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelial transition (MET) exon 14 skipping alterations Renal Dose Adjustments Mild or moderate renal...
...minimum dose is not met after initial product manufacturing, the patient should undergo additional cycles of mobilization and apheresis; each cycle must be separated by a minimum of 14 days. The collected 2 x 10(6) CD34+ cells/kg or more of unmodified backup cells should be cryopreserved before...
...weeks until treatment failure Treatment Criteria: Requirements before the first dose is given: The absolute neutrophil count (ANC) must be 1 x 10(9) or greater AND the platelet count must be 75 x 10(9) or greater AND hemoglobin must be less than 17 g/dL. Retreatment criteria: The absolute neutrophil...
...a day; after a month, if platelet count has not increased to at least 50 x 10(9)/L, increase to 150 mg orally 2 times a day Comments: This drug may be taken with or without food. In the case of a missed dose, instruct patients to take their next dose at its regularly scheduled time. Use the lowest...
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Cell Lung Cancer 1.9 mg/kg IV every 2 weeks Maximum dose: 190 mg/dose Duration of therapy: Until disease progression or unacceptable toxicity Comments: Infuse over at least 30 minutes. Select patients for treatment based on the presence of high c-Met protein overexpression using an approved US FDA test...
...phosphatase occurred in 34%, 4.8%, and 9% of patients, respectively, with 2.2%, 0.4%, and 0.9%, respectively, reported as grade 3 or 4. Laboratory criteria for Hy's law was met in 2 patients who had concurrent elevations in ALT or AST greater than 3 times the upper limit of normal (3 x ULN) and total...
Actoplus Met Dosage 2.1 Important Dosage and Administration Information Obtain liver tests (serum alanine and aspartate aminotransferases, alkaline phosphatase, and total bilirubin) prior to initiating ACTOPLUS MET. ACTOPLUS MET contains 15 mg of pioglitazone and 850 mg of metformin...
...lung cancer (NSCLC) that: has spread to other parts of the body (metastatic), and whose tumors have an abnormal mesenchymal-epithelial transition (MET) gene. Your healthcare provider will perform a test to make sure that Tepmetko is right for you. Tepmetko works by targeting MET. The MET protein is a...
...%, and 0.9%, respectively, reported as grade 3 or 4. Laboratory criteria for Hy's law was met in 2 patients who had concurrent elevations in ALT or AST greater than 3 times the upper limit of normal (3 x ULN) and total bilirubin greater than 2 x ULN; these events were associated with cases of autoimmune...
