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Generic Name: atazanavir (a ta ZAN a vir)
Brand Names: Reyataz

What is Reyataz?

Reyataz (atazanavir) is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Reyataz is used with other medications to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Atazanavir is not a cure for HIV or AIDS.

Reyataz is for use in adults and children who are at least 3 months old and weigh at least 11 pounds (5 kilograms).

Important information

Some medicines can cause unwanted or dangerous effects when used with Reyataz. Your doctor may need to change your treatment plan if you use any of the following drugs: alfuzosin, cisapride, indinavir, irinotecan, lovastatin, simvastatin, pimozide, rifampin, sildenafil (for treating pulmonary arterial hypertension), St. John's wort, triazolam, oral midazolam, or ergot medicine (dihydroergotamine, ergotamine, ergonovine, methylergonovine).

Before taking this medicine

You should not use Reyataz if you have ever had a severe allergic reaction to atazanavir.

Some medicines can cause unwanted or dangerous effects when used with Reyataz. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • alfuzosin;

  • cisapride;

  • irinotecan;

  • rifampin;

  • sildenafil (Revatio, for treating pulmonary arterial hypertension);

  • St. John's wort;

  • antipsychotic medicine - lurasidone, pimozide;

  • ergot medicines - dihydroergotamine, ergotamine, ergonovine, methylergonovine;

  • HIV medicines - indinavir, nevirapine;

  • medicine to lower cholesterol - lovastatin, simvastatin; or

  • sedative medicines - triazolam, oral midazolam.

To make sure Reyataz is safe for you, tell your doctor if you have ever had:

  • liver disease (especially hepatitis B or C);

  • kidney disease (or if you are on dialysis);

  • kidney stones or gallstones;

  • diabetes;

  • a bleeding disorder such as hemophilia; or

  • a heart rhythm disorder, a heart condition called "AV block."

Reyataz oral powder may contain phenylalanine. Talk to your doctor before using this form of atazanavir if you have phenylketonuria (PKU).

HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Your dose needs may be different during pregnancy and for a short time after childbirth.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of atazanavir on the baby.

Reyataz can make birth control pills, patches, injections, or vaginal rings less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking this medicine.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Reyataz should not be given to a child younger than 3 months old and weighing less than 11 pounds (5 kilograms).

How should I take Reyataz?

Take Reyataz exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Reyataz is often used together with another medicine called ritonavir (Norvir).

Reyataz should be taken once daily with food. Swallow the capsule whole.

To give the powder medicine to a child, mix the contents of the packet in a tablespoon of food, milk, or water. Give the entire mixture within one hour of mixing. If you are using water to mix the medicine, give it to your child with food. You may also mix the medicine with infant formula if you are giving the medicine to a baby too young for solid foods. You may use a special dose-measuring spoon or medicine cup to mix the medicine, ask your pharmacist for one.

Give the ritonavir dose to your child immediately after giving the Reyataz powder.

While using this medicine, you may need frequent blood tests. Your liver function may also need to be checked.

Use Reyataz regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store at room temperature away from moisture and heat.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 6 hours away. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Reyataz?

If you also take didanosine (Videx EC), an antacid, or a buffered medicine: Take atazanivir with food at least 2 hours before or 1 hour after taking any of these other medicines.

Taking Reyataz will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Reyataz side effects

Get emergency medical help if you have signs of an allergic reaction to Reyataz: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Reyataz and call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • severe pain in your side or lower back, painful urination, blood in your urine;

  • high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss;

  • liver or gallbladder problems - nausea, vomiting, upper stomach pain, itching, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • severe skin reaction - fever, flu symptoms, mouth sores, burning or redness in your eyes, swelling in your face or tongue, muscle or joint pain, skin pain and warmth or blistering.

Atazanavir may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with Reyataz. Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, mouth sores, diarrhea, stomach pain, weight loss;

  • chest pain (especially when you breathe), dry cough, wheezing, feeling short of breath;

  • cold sores, sores on your genital or anal area;

  • rapid heart rate, feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

  • trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

Common Reyataz side effects may include:

  • fever;

  • nausea, vomiting, stomach pain, diarrhea;

  • muscle pain, mild itching or rash;

  • headache, dizziness, depressed mood, sleep problems (insomnia);

  • numbness, tingling, or burning pain in your hands or feet; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Reyataz?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with atazanavir, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Reyataz.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Reyataz only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 10.01.

Date modified: August 11, 2017
Last reviewed: June 22, 2017

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