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Up and Up Migraine Relief

Generic Name: acetaminophen, aspirin, caffeine
Dosage Form: tablet

Medically reviewed on July 3, 2017

Active ingredient (in each caplet)

Acetaminophen 250 mg

Aspirin 250 mg

Caffeine 65 mg


Pain reliever

Pain reliever aid


  • treats migraine


Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

Allergy alert: Aspirin may cause a severe allergic reaction which may include:

  • hives
  • facial swelling
  • asthma (wheezing)
  • shock

Alcohol warning: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take acetaminophen and aspirin or other pain relievers/fever reducers. Acetaminophen and aspirin may cause liver damage and stomach bleeding.

Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

Do not use

  • if you have ever had an allergic reaction to any other pain reliever/fever reducer
  • with any other products containing acetaminophen (see Overdose Warning)

Ask a doctor before use if you have

  • never had migraines diagnosed by a health professional
  • a headache that is different from your usual migraines
  • the worst headache of your life
  • fever and stiff neck
  • headaches beginning after or caused by head injury, exertion, coughing or bending
  • experienced your first headache after the age of 50
  • daily headaches
  • a migraine so severe as to require bed rest
  • asthma
  • bleeding problems
  • ulcers
  • stomach problems such as heartburn, upset stomach, or stomach pain that do not go away or recur
  • problems or serious side effects from taking pain relievers or fever reducers
  • vomiting with your migraine headache

Ask a doctor or pharmacist before use if you are

  • taking a prescription drug for:
  • anticoagulation (thinning of the blood)
  • diabetes
  • gout
  • arthritis
  • under a doctor’s care for any serious condition
  • taking any other drug
  • taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer

Stop use and ask a doctor if

  • an allergic reaction occurs. Seek medical help right away.
  • your migraine is not relieved or worsens after first dose
  • new or unexpected symptoms occur
  • stomach pain or upset gets worse or lasts
  • ringing in the ears or loss of hearing occurs

If pregnant or breast-feeding,

ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children.

Overdose warning: Taking more than the recommended dose can cause serious health problems, including serious liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


  • do not use more than directed (see Overdose Warning)
  • adults: take 2 caplets with a glass of water
  • if symptoms persist or worsen, ask your doctor
  • do not take more than 2 caplets in 24 hours, unless directed by a doctor
  • under 18 years of age: ask a doctor

Other information

  • store at 20°-25°C (68°-77°F)
  • read all product information before using. Keep this box for important information.

Inactive ingredients

carnauba wax, crospovidone, FD&C blue #1 aluminum lake, hypromellose, microcrystalline cellulose, povidone, pregelatinized starch, propylene glycol, saccharin sodium, stearic acid, titanium dioxide


Call 1-800-910-6874

Principal Display Panel

Migraine Relief

Acetaminophen, Aspirin and Caffeine Tablets

Pain Reliever/Pain Reliever Aid

Compare to active ingredients in Excedrin® Migraine

# Caplets (Replace "#" with number in package}

(**Capsule-Shaped Tablets)

Shown Actual Size Above

Migraine Relief Carton

Up and Up Migraine Relief 
acetaminophen, aspirin, caffeine tablet
Product Information
Product Type HUMAN OTC DRUG Item Code (Source) NDC:11673-374
Route of Administration ORAL DEA Schedule     
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
Product Characteristics
Color WHITE Score no score
Shape CAPSULE Size 17mm
Flavor Imprint Code L374
# Item Code Package Description
1 NDC:11673-374-78 1 BOTTLE (BOTTLE) in 1 CARTON
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
ANDA ANDA077114 06/12/2009
Labeler - Target Corporation (006961700)
Target Corporation

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