Quinupristin and Dalfopristin
(kwi NYOO pris tin & dal FOE pris tin)
- Dalfopristin and Quinupristin
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Injection, powder for reconstitution:
Synercid®: 500 mg: Quinupristin 150 mg and dalfopristin 350 mg
Brand Names: U.S.
- Antibiotic, Streptogramin
Quinupristin/dalfopristin inhibits bacterial protein synthesis by binding to different sites on the 50S bacterial ribosomal subunit thereby inhibiting protein synthesis
Quinupristin: 0.45 L/kg; dalfopristin: 0.24 L/kg
Quinupristin is conjugated with glutathione and cysteine to active metabolites; dalfopristin is hydrolyzed to an active metabolite
Feces (75% to 77% as unchanged drug and metabolites); urine (15% to 19%)
Quinupristin: 0.85 hour; Dalfopristin: 0.7 hour (mean elimination half-lives, including metabolites: 3 and 1 hours, respectively)
Use: Labeled Indications
Skin and skin structure infections, complicated: Treatment of complicated skin and skin structure infections caused by methicillin-susceptible Staphylococcus aureus or Streptococcus pyogenes
Off Label Uses
Bacteremia (methicillin-resistant Staphylococcus aureus)
Based on the Infectious Diseases Society of America (IDSA) Practice Guidelines for the Treatment of Methicillin-Resistant Staphylococcus aureus, quinupristin and dalfopristin may be considered for the treatment of persistent MRSA bacteremia associated with vancomycin failure and when reduced susceptibility to vancomycin and daptomycin is present.
Infective endocarditis (methicillin resistant Staphylococcus aureus), treatment (adults)
Data from a multicenter, open-label, non-comparative trial in patients with culture proven methicillin resistant staphylococcus aureus (MRSA) infections, including patients with infective endocarditis, suggested that quinupristin/dalfopristin may be considered as a treatment option in patients with MRSA infective endocarditis who do not respond to other clinically appropriate antibiotics [Drew 2000]. Additional data is necessary to further define the role of quinupristin/dalfopristin in the treatment of this condition. Overall, the use of quinupristin and dalfopristin has fallen out of favor, including in cases requiring salvage therapy, because of severe side effects (eg, intractable muscle pain), bacteriostatic activity, and need for a central line for administration [Fuchs 2000], [Kullar 2016].
Based on the 2015 European Society of Cardiology guidelines for the management of infective endocarditis, the use of quinupristin/dalfopristin with or without a beta-lactam has been suggested as an alternative in the treatment of patients with infective endocarditis due to MRSA. The 2015 American Heart Association guidelines for infective endocarditis in adults do not formally recommend quinupristin/dalfopristin in patients with MRSA infective endocarditis (AHA [Baddour 2015]).
Infective endocarditis (multidrug resistant Enterococcus faecium), treatment (adults)
Data from in vitro checkerboard and time-kill assays suggest that the use of quinupristin/dalfopristin in combination with other antimicrobial agents may be useful in the treatment of patients with infective endocarditis due to multidrug resistant Enterococcus faecium (Matsumura 1999). In addition, data from two case reports in patients with infective endocarditis due to vancomycin-resistant E. faecium, experienced cure with the use of quinupristin/dalfopristin in combination with other antibiotics (eg, high-dose ampicillin or the combination of doxycycline and rifampin) [Matsumura 1998], [Thompson 2003]. Additional data is necessary to further define the role of quinupristin/dalfopristin in the treatment of this condition.
Based on the 2015 European Society of Cardiology guidelines for the management of infective endocarditis, the use of quinupristin/dalfopristin may be considered as an alternate agent in the treatment of patients with infective endocarditis due to multidrug-resistant E. faecium. The 2015 American Heart Association guidelines for infective endocarditis in adults do not formally recommend quinupristin/dalfopristin in patients with infective endocarditis due to multidrug-resistant E. faecium and state that although active in vitro against strains of E. faecium, it is rarely used because of severe side effects (eg, intractable muscle pain) [AHA [Baddour 2015]].
Intravascular catheter-associated bloodstream infection (methicillin-resistant coagulase negative staphylococci or ampicillin- and vancomycin-resistant E. faecium)
Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of intravascular catheter-related infection, quinupristin and dalfopristin is suggested as an alternative treatment for infection due to methicillin-resistant coagulase negative staphylococci or ampicillin- and vancomycin-resistant E. faecium.
Hypersensitivity to quinupristin, dalfopristin, other streptogramins (eg, pristinamycin, virginiamycin), or any component of the formulation
Skin and skin structure infection, complicated: IV: 7.5 mg/kg every 12 hours for at least 7 days
Bacteremia (methicillin-resistant Staphylococcus aureus) (off-label use): IV: 7.5 mg/kg every 8 hours (Liu 2011). Note: May be considered with vancomycin failure and when reduced susceptibility to vancomycin and daptomycin is present.
Infective endocarditis (methicillin-resistant Staphylococcus aureus), treatment (off-label use): IV: 7.5 mg/kg every 8 hours with or without additional antibiotics (Chesi 2006; ESC [Habib 2015]). Additional data is necessary to further define the role of quinupristin/dalfopristin in the treatment of this condition.
Infective endocarditis (multidrug-resistant Enterococcus faecium), treatment (off-label use): IV: 7.5 mg/kg every 8 hours with other antibiotics (eg, high-dose ampicillin or the combination of doxycycline and rifampin) (ESC [Habib 2015]; Matsumura 1998; Thompson 2003)
Intravascular catheter-associated bloodstream infection (methicillin-resistant coagulase negative staphylococci or ampicillin- and vancomycin-resistant E. faecium) (off-label use): IV: 7.5 mg/kg every 8 hours (IDSA [Mermel 2009])
Refer to adult dosing.
Skin and skin structure infection, complicated: Children ≥12 years and Adolescents: Refer to adult dosing.
Dosing: Renal Impairment
No dosage adjustment necessary.
Dosing: Hepatic Impairment
There are no dosage adjustments provided in the manufacturer’s labeling. However, pharmacokinetic data suggest dosage adjustment may be necessary.
Reconstitute vial with 5 mL of D5W or sterile water for injection to provide a final concentration of 100 mg/mL. Swirl gently to dissolve; do not shake (to limit foam formation). The reconstituted solution should be further diluted within 30 minutes. Reconstituted solution should be added to at least 250 mL of D5W for peripheral administration (increase to 500 mL or 750 mL if necessary to limit venous irritation). An infusion volume of 100 mL may be used for central line infusions.
Line should be flushed with 5% dextrose in water prior to and following administration. Infusion should be completed over 60 minutes (toxicity may be increased with shorter infusion). If severe venous irritation occurs following peripheral administration, quinupristin/dalfopristin may be further diluted (to 500 mL or 750 mL), infusion site changed, or infused by a central venous catheter. In general, administration by central venous catheter is required to avoid phlebitis (Kullar 2016; O'Driscoll 2015).
Store intact vials at 2°C to 8°C (36°F to 46°F). Stability of the solution diluted in D5W prior to the infusion is 5 hours at room temperature or 54 hours at 2°C to 8°C (36°F to 46°F); do not freeze. Extended storage information may be available; contact product manufacturer to obtain current recommendations.
ARIPiprazole: CYP3A4 Inhibitors (Weak) may increase the serum concentration of ARIPiprazole. Management: Monitor for increased aripiprazole pharmacologic effects. Aripiprazole dose adjustments may or may not be required based on concomitant therapy and/or indication. Consult full interaction monograph for specific recommendations. Monitor therapy
CycloSPORINE (Systemic): Quinupristin may increase the serum concentration of CycloSPORINE (Systemic). Monitor therapy
Dofetilide: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Dofetilide. Monitor therapy
Flibanserin: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Flibanserin. Monitor therapy
HYDROcodone: CYP3A4 Inhibitors (Weak) may increase the serum concentration of HYDROcodone. Monitor therapy
Lomitapide: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Lomitapide. Management: Patients on lomitapide 5 mg/day may continue that dose. Patients taking lomitapide 10 mg/day or more should decrease the lomitapide dose by half. The lomitapide dose may then be titrated up to a max adult dose of 30 mg/day. Consider therapy modification
NiMODipine: CYP3A4 Inhibitors (Weak) may increase the serum concentration of NiMODipine. Monitor therapy
Pimozide: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Pimozide. Avoid combination
Hepatic: Hyperbilirubinemia (3% to 35%)
Local: Local pain (40% to 44%), local inflammation (at infusion site: 38% to 42%), localized edema (17% to 18%), infusion site reaction (12% to 13%)
Neuromuscular & skeletal: Arthralgia (≤47%), myalgia (≤47%)
1% to 10%:
Cardiovascular: Thrombophlebitis (2%)
Central nervous system: Pain (2% to 3%), headache (2%)
Dermatologic: Skin rash (3%), pruritus (2%)
Endocrine & metabolic: Increased lactate dehydrogenase (3%), increased gamma-glutamyl transferase (2%), hyperglycemia (1%)
Gastrointestinal: Nausea (3% to 5%), vomiting (3% to 4%), diarrhea (3%)
Hematologic & oncologic: Anemia (3%)
Neuromuscular & skeletal: Increased creatine phosphokinase (2%)
<1% (Limited to important or life-threatening): Anaphylactoid reaction, apnea, brain disease, cardiac arrhythmia, dysautonomia, dyspnea, gout, hematuria, hemolytic anemia, hepatitis, hyperkalemia, hypersensitivity reaction, hypotension, maculopapular rash, mesenteric artery occlusion, myasthenia, neuropathy, pancreatitis, pancytopenia, paraplegia, paresthesia, pericarditis, pleural effusion, pseudomembranous colitis, respiratory distress, seizure, shock, stomatitis, syncope, thrombocytopenia, urticaria
Concerns related to adverse effects:
• Arthralgias/myalgias: May cause arthralgias and/or myalgias, sometimes severe; reversible with treatment discontinuation. Reduction of dosing frequency has led to improvement in some patients.
• Hyperbilirubinemia: May cause hyperbilirubinemia (>5 times ULN; primarily conjugated bilirubin) possibly through competition for excretory pathways.
• Phlebitis: May cause pain and phlebitis when infused through a peripheral line (not relieved by hydrocortisone or diphenhydramine).
• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.
Concurrent drug therapy issues:
• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.
Culture and sensitivity, conjugated bilirubin if clinically indicated
Adverse events have not been observed in animal reproduction studies.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience diarrhea. Have patient report immediately to prescriber muscle pain, joint pain, injection site pain or irritation, jaundice, or signs of Clostridium difficile (C. diff)-associated diarrhea (abdominal pain or cramps, severe diarrhea or watery stools, or bloody stools) (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
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Other brands: Synercid