Medically reviewed by Drugs.com. Last updated on Aug 30, 2020.
(byoo TEN a feen)
- Butenafine Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External, as hydrochloride:
Lotrimin Ultra: 1% (30 g [DSC]) [contains benzyl alcohol, cetyl alcohol, propylene glycol, sodium benzoate]
Lotrimin Ultra: 1% (12 g, 30 g) [contains benzyl alcohol, cetyl alcohol, propylene glycol, sodium benzoate, trolamine (triethanolamine)]
Mentax: 1% (15 g, 30 g) [contains benzyl alcohol, sodium benzoate]
Generic: 1% (12 g, 30 g)
Brand Names: U.S.
- Lotrimin Ultra [OTC]
- Antifungal Agent, Topical
Butenafine exerts fungicidal activity against dermatophytes (eg trichophyton, epidermophyton) by blocking squalene epoxidation, resulting in inhibition of ergosterol synthesis and subsequent weakening of fungal cell membranes.
Hepatic via hydroxylation
Time to Peak
Serum: 6 to 15 hours
Biphasic: Alpha: 35 hours; Beta: >150 hours
Use: Labeled Indications
Topical infections: Topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur
OTC labeling: Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)
Hypersensitivity to butenafine or any component of the formulation
OTC labeling: When used for self-medication, do not use on nails or scalp, in or near the mouth or eyes, or for vaginal yeast infections
Tinea corporis, tinea cruris: Topical: Apply once daily for 2 weeks to affected area
Tinea versicolor: Topical: Apply once daily for 2 weeks to affected area and surrounding skin
Tinea pedis: Topical: Apply twice daily for 1 week or once daily for 4 weeks to affected skin between and around the toes
Refer to adult dosing.
Children ≥12 years and Adolescents: Refer to adult dosing.
Topical: For external use only; avoid contact with eyes, mouth, nose, or other mucous membranes. Apply to clean, dry skin. Avoid occlusive dressings.
Tinea pedis: Wear well-fitted, ventilated shoes; change socks and shoes at least once daily.
Lotrimin Ultra: Store at 20° to 25°C (68° to 77°F).
Mentax: Store at 5°C to 30°C (41°F to 86°F).
There are no known significant interactions.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
≥1%: Dermatologic: Burning sensation of skin, contact dermatitis, erythema, pruritus, skin irritation, stinging of the skin
Concerns related to adverse effects:
• Allylamine antifungal hypersensitivity: Use caution in patients sensitive to allylamine antifungals (eg naftifine, terbinafine); cross sensitivity to butenafine may exist.
• Irritation: Discontinue if sensitivity or irritation occurs.
• Immunocompromised patients: Has not been studied in immunocompromised patients.
• Appropriate use: For external use only; avoid contact with eyes, mouth, nose, or other mucous membranes.
Culture and KOH exam, clinical signs of tinea pedis
Pregnancy Risk Factor
Adverse effects were not observed in animal reproduction studies.
What is this drug used for?
• It is used to treat fungal infections of the skin.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Application site irritation
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about butenafine topical
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Pricing & Coupons
- En Español
- Drug class: topical antifungals
Other brands: Mentax