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Butenafine

Medically reviewed by Drugs.com. Last updated on Aug 30, 2020.

Pronunciation

(byoo TEN a feen)

Index Terms

  • Butenafine Hydrochloride

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External, as hydrochloride:

Lotrimin Ultra: 1% (30 g [DSC]) [contains benzyl alcohol, cetyl alcohol, propylene glycol, sodium benzoate]

Lotrimin Ultra: 1% (12 g, 30 g) [contains benzyl alcohol, cetyl alcohol, propylene glycol, sodium benzoate, trolamine (triethanolamine)]

Mentax: 1% (15 g, 30 g) [contains benzyl alcohol, sodium benzoate]

Generic: 1% (12 g, 30 g)

Brand Names: U.S.

  • Lotrimin Ultra [OTC]
  • Mentax

Pharmacologic Category

  • Antifungal Agent, Topical

Pharmacology

Butenafine exerts fungicidal activity against dermatophytes (eg trichophyton, epidermophyton) by blocking squalene epoxidation, resulting in inhibition of ergosterol synthesis and subsequent weakening of fungal cell membranes.

Absorption

Minimally systemic

Metabolism

Hepatic via hydroxylation

Time to Peak

Serum: 6 to 15 hours

Half-Life Elimination

Biphasic: Alpha: 35 hours; Beta: >150 hours

Use: Labeled Indications

Topical infections: Topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur

OTC labeling: Topical treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)

Contraindications

Hypersensitivity to butenafine or any component of the formulation

OTC labeling: When used for self-medication, do not use on nails or scalp, in or near the mouth or eyes, or for vaginal yeast infections

Dosing: Adult

Tinea corporis, tinea cruris: Topical: Apply once daily for 2 weeks to affected area

Tinea versicolor: Topical: Apply once daily for 2 weeks to affected area and surrounding skin

Tinea pedis: Topical: Apply twice daily for 1 week or once daily for 4 weeks to affected skin between and around the toes

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Children ≥12 years and Adolescents: Refer to adult dosing.

Administration

Topical: For external use only; avoid contact with eyes, mouth, nose, or other mucous membranes. Apply to clean, dry skin. Avoid occlusive dressings.

Tinea pedis: Wear well-fitted, ventilated shoes; change socks and shoes at least once daily.

Storage

Lotrimin Ultra: Store at 20° to 25°C (68° to 77°F).

Mentax: Store at 5°C to 30°C (41°F to 86°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

≥1%: Dermatologic: Burning sensation of skin, contact dermatitis, erythema, pruritus, skin irritation, stinging of the skin

Warnings/Precautions

Concerns related to adverse effects:

• Allylamine antifungal hypersensitivity: Use caution in patients sensitive to allylamine antifungals (eg naftifine, terbinafine); cross sensitivity to butenafine may exist.

• Irritation: Discontinue if sensitivity or irritation occurs.

Special populations:

• Immunocompromised patients: Has not been studied in immunocompromised patients.

Other warnings/precautions:

• Appropriate use: For external use only; avoid contact with eyes, mouth, nose, or other mucous membranes.

Monitoring Parameters

Culture and KOH exam, clinical signs of tinea pedis

Pregnancy Risk Factor

C

Pregnancy Considerations

Adverse effects were not observed in animal reproduction studies.

Patient Education

What is this drug used for?

• It is used to treat fungal infections of the skin.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Burning

• Stinging

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Application site irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.