Medically reviewed by Drugs.com. Last updated on Feb 10, 2019.
(BYE oh tin)
- Coenzyme R
- Vitamin B7
- Vitamin H
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Meribin: 5 mg
Capsule, Oral [preservative free]:
Generic: 5000 mcg
Generic: 1000 mcg, 5 mg, 10 mg
Tablet, Oral [preservative free]:
Generic: 300 mcg [DSC], 1000 mcg
Brand Names: U.S.
- Meribin [OTC]
- Biotinidase Deficiency, Treatment Agent
- Nutritional Supplement
- Vitamin, Water Soluble
Functions as a coenzyme; involved in carboxylation, transcarboxylation, and decarboxylation reactions of gluconeogenesis, lipogenesis, fatty acid synthesis, propionate metabolism, and the catabolism of leucine
Use: Labeled Indications
Dietary supplement: As a biotin dietary supplement
Dietary supplementation (OTC labeling): Oral: Usual dosage: One tablet or capsule daily; also see specific product labeling
Refer to adult dosing.
Adequate intake (AI): Note: There is no official RDA (IOM 1998).
1 to 6 months: 5 mcg/day (~0.7 mcg/kg/day)
7 to 12 months: 6 mcg/day (~0.7 mcg/kg/day)
Children and Adolescents:
1 to 3 years: 8 mcg/day
4 to 8 years: 12 mcg/day
9 to 13 years: 20 mcg/day
14 to 18 years: 25 mcg/day
Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents: Oral: 5 to 20 mg once daily (McVoy 1990; Micó 2011; Salbert 1993; Wolf 2003; Wolf 2010)
Oral: May be administered without regard to meals; may be preferable to take with meals
Adequate intake (IOM 1998):
0 to 6 months: 5 mcg daily (~0.7 mcg/kg)
7 to 12 months: 6 mcg daily (~0.7 mcg/kg)
1 to 3 years: 8 mcg daily
4 to 8 years: 12 mcg daily
9 to 13 years: 20 mcg daily
14 to 18 years: 25 mcg daily
≥19 years: 30 mcg daily
Pregnancy: 30 mcg daily
Lactation: 35 mcg daily
Biotin can significantly interfere with certain lab tests and cause incorrect test results that may go undetected, possibly leading to inappropriate patient management or misdiagnosis (FDA Medwatch Alert 2017).
There are no adverse reactions listed in the manufacturer’s labeling.
• RDA values: Are not requirements, but are recommended daily intakes of certain essential nutrients.
• Laboratory test interaction: Biotin in blood or other samples taken from patients who are ingesting high levels of biotin from dietary supplements (including multivitamins; prenatal multivitamins; biotin supplements; and dietary supplements for hair, skin, and nail growth) can cause clinically significant incorrect lab test results. Some testing methods use biotin technology (eg, Troponin, hormone tests), using biotin to bind to specific proteins that are measured to detect health conditions. An increase in the number of reported adverse events, including one death, related to biotin interference with lab tests has been reported. If a lab test result does not correspond with a patient's clinical symptoms, biotin interference should be considered as a possible source of error (FDA Medwatch Alert 2017).
Water soluble vitamins cross the placenta (IOM 1998).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
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