Medically reviewed by Drugs.com. Last updated on Jul 12, 2020.
(ay SYE kloe veer)
- Antiviral Agent, Ophthalmic
Acyclovir is converted to acyclovir monophosphate by virus-specific thymidine kinase then further converted to acyclovir triphosphate by other cellular enzymes. Acyclovir triphosphate inhibits DNA synthesis and viral replication by competing with deoxyguanosine triphosphate for viral DNA polymerase and being incorporated into viral DNA.
Not detected in blood by existing bioanalytical methods
Trace quantities are detectable in the urine but are not therapeutically relevant
Use: Labeled Indications
Herpetic keratitis: Treatment of acute herpetic keratitis (dendritic ulcers) in patients with herpes simplex (HSV-1 and HSV-2) virus
Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation
Herpetic keratitis: Ophthalmic: Apply a ½-inch ribbon of ointment in the lower cul-de-sac of the affected eye(s) 5 times daily (approximately every 3 hours while awake) until the corneal ulcer heals, then apply a ½-inch ribbon 3 times daily for 7 days.
Refer to adult dosing.
Herpes simplex keratitis: Children ≥2 years and Adolescents: Ophthalmic: Apply a 1 cm ribbon in the lower eyelid of affected eye(s) 5 times a day (~every 3 hours while awake) until corneal ulcer heals, then apply a 1 cm ribbon 3 times daily for 7 more days
Ophthalmic: For topical ophthalmic use only; avoid touching tip of applicator to eye(s) or other surfaces. After application close the eye(s) for 1 to 2 minutes; excess ointment may be wiped away.
Store at 20°C to 25°C (68°F to 77°F).
There are no known significant interactions.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%: Ophthalmic: Eye pain, follicular conjunctivitis, punctate keratitis, stinging of eyes
<1%, postmarketing, and/or case reports: Angioedema, blepharitis, type I hypersensitivity reaction, urticaria
There are no warnings listed in the manufacturer’s labeling.
Acyclovir has not been detected in the blood following ophthalmic administration; limited systemic absorption would limit potential exposure to the fetus. Results from a pregnancy registry, established in 1984 and closed in 1999, did not find an increase in the number of birth defects with exposure to systemic acyclovir when compared to those expected in the general population.
What is this drug used for?
• It is used to treat eye infections caused by herpes virus.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
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• Eye pain
• Severe eye irritation
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