Generic Name: tenecteplase (ten EK te plase)
Brand Name: TNKase
Medically reviewed on March 6, 2017
What is TNKase?
TNKase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
TNKase is used to prevent death in people who have had a heart attack (acute myocardial infarction).
TNKase may also be used for purposes not listed in this medication guide.
If possible before you receive TNKase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.
In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.
Before taking this medicine
You should not be treated with TNKase if you are allergic to it, or if you have:
active bleeding inside your body;
a recent history of medical trauma or injury;
severe or uncontrolled high blood pressure;
a genetic disorder affecting the blood vessels in your brain;
a brain tumor, blood vessel disorder, or aneurysm (dilated blood vessel);
a bleeding or blood clotting disorder (such as hemophilia);
a history of stroke; or
if you have had brain or spinal cord injury or surgery within the past 2 months.
If possible before you receive TNKase, tell your doctor if you have:
a past history of strokes;
a recent history of bleeding in your brain, stomach, intestines, or urinary tract;
high blood pressure;
an infection of the lining of your heart (also called bacterial endocarditis);
liver or kidney disease;
eye problems caused by diabetes;
severe bruising or infection around a vein where an IV was placed;
if you are pregnant or have recently had a baby;
if you have recently had an organ biopsy; or
if you have recently had a serious injury or major surgery.
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
How is tenecteplase given?
TNKase is injected into a vein through an IV. A healthcare provider will give you this injection.
TNKase is usually given as soon as possible after the first signs of heart attack occur.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you have recently received TNKase.
What happens if I miss a dose?
Since TNKase is used as a single dose, it does not have a daily dosing schedule.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid after receiving TNKase?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
TNKase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
TNKase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.
Call your doctor at once if you have signs of bleeding inside your body, such as:
easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection);
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
red or pink urine; or
Also call your doctor at once if you have:
chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;
swelling, rapid weight gain, little or no urinating;
severe stomach pain, nausea, and vomiting
darkening or purple discoloration of your fingers or toes;
very slow heartbeats, shortness of breath, feeling light-headed;
sudden severe back pain, muscle weakness, numbness or loss of feeling in your arms or legs,
dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats; or
Common side effects may include:
nausea, vomiting; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect TNKase?
Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Other drugs may interact with tenecteplase, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.01.
More about TNKase (tenecteplase)
- TNKase Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
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- Drug class: thrombolytics