Generic Name: ocrelizumab (OK re LIZ ue mab)
Brand Name: Ocrevus
What is ocrelizumab?
Ocrelizumab is a monoclonal antibody that affects the actions of the body's immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.
Ocrelizumab is used to treat multiple sclerosis (relapsing or progressive forms).
Ocrelizumab may also be used for purposes not listed in this medication guide.
Ocrelizumab may cause unpleasant side effects while the medicine is injected, or up to 24 hours later. Tell your caregivers right away if you have any unusual discomfort during the injection.
Before taking this medicine
You should not be treated with ocrelizumab if you are allergic to it, or if you have:
active infection with hepatitis B.
Tell your doctor if you have received any vaccine within the past 6 weeks.
To make sure ocrelizumab is safe for you, tell your doctor if you have:
any type of active infection;
a history of using medicine that can weaken your immune system;
if you are a carrier of hepatitis B; or
if you are scheduled to receive any vaccines.
Using ocrelizumab may increase your risk of developing certain types of cancer, such as breast cancer. Ask your doctor about your specific risk.
It is not known whether ocrelizumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
It is not known whether ocrelizumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
How is ocrelizumab given?
Before you start treatment with ocrelizumab, your doctor may perform tests to make sure you do not have hepatitis B or other infections.
Ocrelizumab is injected into a vein through an IV. A healthcare provider will give you this injection.
You may be given other medications to prevent certain side effects of ocrelizumab.
Your first dose of ocrelizumab will be split into 2 separate infusions. You will receive these infusions 2 weeks apart. The following doses will be given once every 6 months.
Ocrelizumab must be given slowly and each infusion can take up to 3 hours and 30 minutes to complete.
You will be watched closely for at least 1 hour after receiving ocrelizumab, to make sure you do not have an allergic reaction to the medication.
If you have ever had hepatitis B, ocrelizumab can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of ocrelizumab.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving ocrelizumab?
Do not receive a "live" vaccine while using ocrelizumab, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Ocrelizumab side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection or up to 24 hours later. Tell your caregiver right away if you feel dizzy, sleepy, nauseated, light-headed, feverish, sweaty, itchy, or have a red skin rash, headache, fast heartbeats, chest tightness, trouble breathing, or swelling and irritation in your throat.
Call your doctor at once if you have:
fever, chills, cough with yellow or green mucus;
stabbing chest pain, wheezing, feeling short of breath;
skin warmth, redness, or swelling;
skin sores, blisters, pus, or oozing;
cold sores or fever blisters on or around your lips;
nerve pain (tingling, burning pain, "pins and needles" feeling);
mood or behavior changes, confusion, memory problems;
weakness on one side of your body; or
problems with vision, speech, or walking.
Your ocrelizumab treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
reactions to an injection; or
respiratory infections (affecting the nose, sinuses, throat, or lungs).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ocrelizumab dosing information
Usual Adult Dose for Multiple Sclerosis:
Initial dose: 300 mg IV followed 2 weeks later by a second 300 mg IV infusion
Maintenance dose: 600 mg IV every 6 months
Manufacturer recommended infusion rates (consult manufacturer product information for more information):
-Infusions 1 and 2 (300 mg of this drug in 250 mL 0.9% sodium chloride injection): Start at 30 mL/hr and increase by 30 mL/hr every 30 minutes to a maximum of 180 mL/hr; duration of 2.5 hours or longer
-Subsequent infusions (600 mg of this drug in 500 mL 0.9% sodium chloride injection): Start at 40 mL/hr and increase by 40 mL/hr every 30 minutes to a maximum of 200 mL/hr; duration of 3.5 hours or longer
-The patient should be premedicated with methylprednisolone (or an equivalent corticosteroid) 100 mg IV approximately 30 minutes prior to each infusion and an antihistamine (e.g., diphenhydramine) approximately 30 to 60 minutes prior to each infusion; the addition of an antipyretic (e.g., acetaminophen) may also be considered.
-The patient should be observed for at least one hour after the completion of the infusion.
-If a planned infusion is missed, administer it as soon as possible; do not wait until the next scheduled dose. Reset the dose schedule to administer the next sequential dose 6 months after the missed dose is administered. Doses must be separated by at least 5 months.
Use: For the treatment of patients with relapsing or primary progressive forms of multiple sclerosis
What other drugs will affect ocrelizumab?
Tell your doctor about all other medicines you have recently used to treat multiple sclerosis.
Other drugs may interact with ocrelizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
More about ocrelizumab
- Ocrelizumab Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
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- Drug class: CD20 monoclonal antibodies
Other brands: Ocrevus