Meningococcal group B vaccine

Generic name: meningococcal group B vaccine
Brand names: Bexsero (MenB), Trumenba, Bexsero
Dosage form: intramuscular suspension (fully recombinant; recombinant, OMV, adjuvanted)
Drug class: Bacterial vaccines

Medically reviewed by Drugs.com on Sep 30, 2024. Written by Cerner Multum.

What is meningococcal group B vaccine?

Meningococcal disease is a bacterial infection that can infect the spinal cord and brain, causing meningitis that can be fatal or lead to permanent and disabling medical problems.

Meningococcal disease can spread from one person to another through small droplets of saliva that are expelled into the air when an infected person coughs or sneezes. The bacteria is usually passed through close contact with an infected person, especially through kissing, or sharing a drinking glass or eating utensil.

Meningococcal group B vaccine is used to prevent infection caused by serogroup B meningococcal bacteria.

This vaccine helps your body develop immunity to meningitis, but will not treat an active infection you already have.

Meningococcal group B vaccine is for use in children and young adults who are 10 to 25 years old.

Like any vaccine, the meningococcal group B vaccine may not provide protection from disease in every person.

This vaccine side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Keep track of all side effects you have. If you need a booster dose, you will need to tell the vaccination provider if the previous shot caused any side effects.

You should not receive a second shot if you had a life-threatening allergic reaction after the first shot.

Becoming infected with meningococcal disease and developing meningitis is much more dangerous to your health than receiving this vaccine. Any vaccine may cause side effects but the risk of serious side effects is low.

You may feel faint after receiving this vaccine. Your doctor may want you to remain under observation during the first 15 minutes after the injection.

Common side effects of meningococcal group B vaccine may include:

• headache;

• feeling tired, chills;

• muscle or joint pain;

• nausea, diarrhea; or

• pain, redness, swelling, or a hard lump where the shot was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

Warnings

You should not receive the vaccine a second time if you had a life threatening allergic reaction after the first shot.

Before taking this medicine

You should not receive this vaccine if you've ever had an allergic reaction to meningococcal group B vaccine.

This vaccine may need to be postponed or not given at all if you have:

• a severe illness with a fever or any type of infection; or

• a weak immune system caused by disease or by using certain medicine (this vaccine may not be as effective if you are immunosuppressed).

You may still receive a vaccine if you have a minor cold.

Your doctor should determine whether you need this vaccine during pregnancy or while breastfeeding.

How is this vaccine given?

This vaccine is given as an injection into a muscle. You will receive this injection in a doctor's office or medical setting.

There are two meningococcal B vaccines available and the same vaccine must be used for all doses.

Meningococcal group B vaccine is usually given in a series of 2 or 3 shots. Booster shots are given 1, 2, or 6 months after the first shot.

Your booster schedule may be different. Follow the guidelines provided by your doctor or local health department.

Be sure to receive all recommended doses of this vaccine or you may not be fully protected against disease.

There are other types of meningococcal vaccine available. When you receive a booster dose, make sure you are receiving a vaccine for meningococcal serogroup B and not for serogroups A, C, W, or Y, unless otherwise directed by your doctor or vaccination provider.

Meningococcal group B vaccine dosing information

Usual Adult Dose for Meningitis -- Meningococcal:

PATIENTS UP TO 25 YEARS OLD:
Two-dose schedule: 0.5 mL IM once, administered at 0 and 6 months
-If the second dose is given less than 6 months after the first dose, a third dose should be given at least 4 months after the second dose

Three-dose schedule: 0.5 mL IM once, administered at 0, 1 to 2, and 6 months

Comments:
-The dosing schedule should be determined by the patient's risk of exposure and the susceptibility to the disease.
-The dosage schedules for Bexsero and Trumenba are the same; however, it is not known if the vaccines are interchangeable.

Use: Active immunization to prevent invasive disease caused by Neisseria meningitidis serogroup B

Usual Pediatric Dose for Meningitis -- Meningococcal:

PATIENTS 10 YEARS AND OLDER:
Two-dose schedule: 0.5 mL IM once, administered at 0 and 6 months
-If the second dose is given less than 6 months after the first dose, a third dose should be given at least 4 months after the second dose

Three-dose schedule: 0.5 mL IM once, administered at 0, 1 to 2, and 6 months

Comments:
-The dosing schedule should be determined by the patient's risk of exposure and the susceptibility to the disease.
-The dosage schedules for Bexsero and Trumenba are the same; however, it is not known if the vaccines are interchangeable.

Use: Active immunization to prevent invasive disease caused by N meningitidis serogroup B

What happens if I miss a dose?

Contact your vaccination provider if you miss a booster dose or if you get behind schedule.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur.

What should I avoid before or after receiving this vaccine?

Follow your vaccination provider's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect this vaccine?

Before receiving this vaccine, tell your doctor about all other vaccines you recently received.

Other drugs may affect meningococcal group B vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Related/similar drugs

ciprofloxacin, dexamethasone, ceftriaxone, Rocephin, rifampin, Decadron, minocycline, penicillin g potassium, meningococcal polysaccharide vaccine, Minocin

Further information

• Your vaccination provider, pharmacist, or doctor can provide more information about this vaccine. Additional information is available from your local health department or the Centers for Disease Control and Prevention.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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