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Generic name: mavacamten [ MAV-a-KAM-ten ]
Brand name: Camzyos
Dosage form: oral capsule (10 mg; 15 mg; 2.5 mg; 5 mg)
Drug class: Miscellaneous cardiovascular agents

Medically reviewed by on Feb 27, 2024. Written by Cerner Multum.

What is mavacamten?

Mavacamten is used in adults to treat a heart problem called obstructive hypertrophic cardiomyopathy (HCM). mavacamten may improve people's symptoms and their ability to be active.

Mavacamten is available only from a certified pharmacy under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

Mavacamten may also be used for purposes not listed in this medication guide.

Mavacamten side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Mavacamten may cause serious side effects. Call your doctor at once if you have:

Common side effects of mavacamten may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Call your doctor at once if you have shortness of breath, chest pain, tiredness, swelling in your legs, rapid weight gain, or racing or pounding heartbeats.

Mavacamten can cause heart failure. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all other medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs should not be used with mavacamten.

Before taking this medicine

Some drugs should not be used with mavacamten. Your treatment plan may change if you also use:

Tell your doctor if you have:

Mavacamten may harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using mavacamten and for at least 4 months after your last dose. Tell your doctor if you become pregnant.

Ask a doctor if it is safe to breastfeed while using mavacamten.

Mavacamten can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.

How should I take mavacamten?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Mavacamten is usually taken once per day.

Your treatment may be delayed or permanently discontinued if you have certain side effects.

Do not change your dose or stop using this medicine without your doctor's advice.

You should get an echocardiogram before and during treatment with mavacamten.

Swallow the capsule whole and do not crush, chew, break, or open it.

Store at room temperature away from moisture and heat.

Mavacamten dosing information

Usual Adult Dose for Hypertrophic Cardiomyopathy:

Starting dose: 5 mg orally once a day
Allowable subsequent doses with titration: 2.5, 5, 10, or 15 mg orally once a day
Maximum dose: 15 mg orally/day

-Patients may develop heart failure while taking this drug; regular left ventricular ejection fraction (LVEF) and Valsalva left ventricular outflow tract (LVOT) gradient assessment is needed for careful titration to achieve an appropriate target Valsalva LVOT gradient, while maintaining LVEF at least 50% and avoiding heart failure symptoms.
-When initiating or titrating this drug, LVEF should be considered first, then the Valsalva LVOT gradient and patient clinical status should be considered to guide appropriate dosing; the algorithms for TREATMENT INITIATION and MAINTENANCE should be followed for appropriate dosing and monitoring schedules.
-If LVEF is less than 50% during therapy, this drug should be interrupted; the algorithm for INTERRUPTION should be followed for guidance on interrupting, restarting, or discontinuing this drug. If interrupted at 2.5 mg, the patient should either restart at 2.5 mg or permanently discontinue this drug.

Use: For the treatment of patients with symptomatic New York Heart Association (NYHA) class II to III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Take your next dose at the regular time and stay on your once-daily schedule. Do not take two doses in one day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking mavacamten?

Grapefruit may interact with mavacamten and cause side effects. Avoid consuming grapefruit products.

What other drugs will affect mavacamten?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect mavacamten, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.