Mavacamten (Monograph)
Brand name: Camzyos
Drug class: Cardiac Drugs, Miscellaneous
Warning
Risk Evaluation and Mitigation Strategy (REMS):
FDA approved a REMS for mavacamten to ensure that the benefits outweigh the risks. The REMS may apply to one or more preparations of mavacamten and consists of the following: elements to assure safe use and implementation system. See the FDA REMS page ([Web]) for further information.
Warning
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Mavacamten can cause heart failure due to systolic dysfunction.
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Echocardiogram assessments of left ventricular ejection fraction (LVEF) required before and during mavacamten use.
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Initiation in patients with LVEF <55% not recommended.
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Interrupt if LVEF <50% or if worsening clinical status.
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Certain CYP-450 inhibitors and inducers are contraindicated in patients taking mavacamten because of an increased risk of heart failure.
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Mavacamten is available only through a restricted program called the Camzyos REMS Program.
Introduction
Cardiac myosin inhibitor.
Uses for Mavacamten
Hypertrophic Cardiomyopathy
Treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms. Designated an orphan drug by FDA for this use.
Has been shown to decrease obstruction and improve exercise capacity, NYHA class, and health status.
The 2024 guideline for management of hypertrophic cardiomyopathy recommends that patients with symptoms attributable to left ventricular outflow obstruction be treated with non-vasodilating β-adrenergic blocking agents titrated to effectiveness or maximally tolerated doses. If such patients do not tolerate or respond to this therapy, substitution with non-dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem) is recommended. For patients who do not respond to trials of ≥1 of these drugs, disopyramide, mavacamten, or septal reduction therapy is recommended.
Mavacamten Dosage and Administration
General
Pretreatment Screening
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Obtain an echocardiogram before starting treatment. Do not initiate treatment in patients with left ventricular ejection fraction (LVEF) <55%.
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Confirm absence of pregnancy and usage of effective contraception in females of reproductive potential.
Patient Monitoring
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Assess echocardiogram during treatment. Interrupt treatment if LVEF <50%.
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Perform regular assessments of LVEF and Valsalva left ventricular outflow tract (LVOT) gradient to guide appropriate dosing.
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Monitor for symptoms of heart failure or worsening clinical status at each visit.
REMS
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Mavacamten is available only through a restricted distribution program called the Camzyos REMS Program. Clinicians, patients, and pharmacies must enroll in the program and complete any necessary requirements in order to prescribe, receive, and dispense the drug. Details of the program can be found on the FDA's REMS website or at [Web].
Administration
Oral Administration
Administer once daily with or without food.
Swallow capsules whole; do not open, break, chew, or crush.
Take a missed dose as soon as it is remembered; do not take 2 doses on the same day.
Dosage
Adults
Obstructive Hypertrophic Cardiomyopathy
Oral
Initiate only if left ventricular ejection (LVEF) ≥55%. Recommended initial dosage is 5 mg once daily.
Individualize dose based on clinical status and echocardiographic assessment. Manufacturer states that allowable subsequent dosages are 2.5 mg, 5 mg, 10 mg, or 15 mg once daily; maximum recommended dosage is 15 mg daily.
First consider LVEF and then consider the Valsalva LVOT gradient and patient clinical status to guide initial dosage and subsequent titration. Initiation or up-titration of mavacamten in patients with LVEF <55% is not recommended. May consider assessment of post-exercise LVOT gradient in symptomatic patients with normal or near normal Valsalva gradients (approximately 30 mm Hg) prior to starting mavacamten therapy. Dose titration and maintenance is based on LVEF and LVOT as described in Table 1.
Clinical monitoring and dose adjustments are recommended every 4 weeks for the first 12 weeks, and then every 12 weeks thereafter during maintenance phase of therapy. Several weeks are necessary for steady-state drug levels and therapeutic effects to be reached; pharmacogenetic variation and drug interactions can also affect drug exposure.
Delay dose increases or interrupt treatment in patients with intercurrent illness (e.g., serious infection) or arrhythmia (e.g., atrial fibrillation or uncontrolled tachyarrhythmias) that could impair systolic function.
For patients with normal or near normal Valsalva LVOT gradient (approximately 30 mm Hg) prior to initiating treatment with mavacamten, if LVEF ≥55% and post-exercise LVOT gradient is ≥30 mm Hg the dose may be increased to the next higher dose level if symptoms persist.
Initial Dosage |
Monitoring and Dosing Instructions at Week 4 |
Monitoring and Dosing Instructions at Week 8 |
Monitoring and Dosing Instructions at Week 12 + every 12 Weeks (Maintenance) |
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5 mg once daily if LVEF ≥55% |
LVEF <50%: interrupt treatment. Recheck ECHO every 4 weeks until LVEF ≥50%; once LVEF ≥50%, restart treatment at the next lower daily dose level (decrease from 5 to 2.5 mg, 10 to 5 mg, or 15 to 10 mg). If interrupted at 2.5 mg, restart at 2.5 mg. Recheck clinical status and ECHO in 4 weeks and maintain the same dosage for the next 8 weeks unless LVEF <50%. Permanently discontinue mavacamten therapy if LVEF <50% occurs twice on a dosage of 2.5 mg daily. Valsalva LVOT <20 mm Hg: reduce to 2.5 mg once daily. Valsalva LVOT ≥20 mm Hg: maintain at 5 mg once daily. |
LVEF <50%: interrupt treatment. Recheck ECHO every 4 weeks until LVEF ≥50%; once LVEF ≥50%, restart treatment at the next lower daily dose level (decrease from 5 to 2.5 mg, 10 to 5 mg, or 15 to 10 mg). If interrupted at 2.5 mg, restart at 2.5 mg. Recheck clinical status and ECHO in 4 weeks and maintain the same dosage for the next 8 weeks unless LVEF <50%. Permanently discontinue mavacamten therapy if LVEF <50% occurs twice on a dosage of 2.5 mg daily. Valsalva LVOT <20 mm Hg in patients receiving 2.5 mg once daily: withhold therapy and return at week 12. Valsalva LVOT ≥20 mm Hg in patients receiving 2.5 mg once daily: continue at 2.5 mg once daily. Valsalva LVOT <20 mm Hg in patients receiving 5 mg once daily: reduce to 2.5 mg once daily. Valsalva LVOT ≥20 mm Hg in patients receiving 5 mg once daily: continue at 5 mg once daily. |
LVEF <50%: interrupt treatment. Recheck ECHO every 4 weeks until LVEF ≥50%; once LVEF ≥50%, restart treatment at the next lower daily dose level (decrease from 5 to 2.5 mg, 10 to 5 mg, or 15 to 10 mg). If interrupted at 2.5 mg, restart at 2.5 mg. Recheck clinical status and ECHO in 4 weeks and maintain the same dosage for the next 8 weeks unless LVEF <50%. Permanently discontinue mavacamten therapy if LVEF <50% occurs twice on a dosage of 2.5 mg daily. If treatment was withheld at week 8 in patients with Valsalva LVOT <20 mm Hg, restart at 2.5 mg once daily as long as LVEF ≥50% and recheck clinical status and ECHO in 4 weeks. Maintain same dosage for the next 8 weeks consistent with maintenance treatment as described below, unless LVEF <50%. LVEF 50 to <55%, regardless of LVOT gradient, maintain on same dose and follow-up 3 months later. LVEF ≥55% and LVOT gradient <30 mm Hg: maintain same dosage. During the initial 6 month cycle, check clinical status after 3 months and recheck clinical status and ECHO at 6 months. Recheck clinical status and ECHO every 6 months. LVEF ≥55% and Valsalva LVOT gradient ≥30 mm Hg: up titrate to next dosage level (2.5 to 5 mg, 5 to 10 mg, or 10 to 15 mg). Recheck clinical status and ECHO in 4 weeks and maintain the same dosage for the next 8 weeks unless LVEF <50%. Further up-titration is allowed after 12 weeks of treatment on the same dose level. |
Dosage Modification for Concomitant Administration of CYP2C19 or CYP3A4 Inhibitors
For patients on stable therapy with a weak cytochrome P450 (CYP) 2C19 or moderate CYP3A4 inhibitor, initiate mavacamten at 5 mg once daily.
For patients on stable therapy with a moderate CYP2C19 inhibitor or a strong CYP3A4 inhibitor, initiate mavacamten at 2.5 mg once daily. If Valsalva LVOT gradient is <20 mm Hg at week 4 or 8, interrupt therapy. Resume treatment after 4 weeks at 2.5 mg once daily if LVEF is ≥50%. If treatment is resumed at week 12, recheck clinical status, Valsava LVOT gradient and LVEF in 4 weeks, and maintain current dose for the next 8 weeks unless LVEF is <50%.
For patients who initiate a weak to moderate CYP2C19 inhibitor or a moderate to strong CYP3A4 inhibitor, reduce mavacamten dosage to next lower daily dose level (i.e., 15 to 10 mg; 10 to 5 mg; or 5 to 2.5 mg). Four weeks after inhibitor initiation, schedule clinical and echocardiographic assessments; do not up-titrate to next higher daily mavacamten dose level until 12 weeks after inhibitor initiation. Avoid initiation of concomitant weak to moderate CYP2C19 and moderate to strong CYP3A4 inhibitors in patients who are on stable treatment with mavacamten 2.5 mg because a lower mavacamten once daily dose is unavailable.
For short-term use (e.g., 1 week), interrupt mavacamten therapy for the duration of treatment with a weak to moderate inhibitor of CYP2C19 or a moderate to strong inhibitor of CYP3A4. May reinitiate mavacamten at the previous dose immediately upon discontinuation of concomitant therapy.
Special Populations
Hepatic Impairment
Mild to moderate hepatic impairment (Child-Pugh class A and B): No dosage adjustment required.
Severe hepatic impairment (Child-Pugh class C): Effects unknown.
Renal Impairment
No specific dosage recommendations.
Geriatric Patients
No specific dosage recommendations.
Cautions for Mavacamten
Contraindications
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Concomitant use of strong CYP2C19 inhibitors.
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Concomitant use of moderate to strong CYP2C19 inducers or moderate to strong CYP3A4 inducers.
Warnings/Precautions
Warnings
Heart Failure
Heart failure due to systolic dysfunction can occur. (See Boxed Warning.) Risk increases with intercurrent illness (e.g., serious infection) or arrhythmia (e.g., atrial fibrillation or other uncontrolled tachyarrhythmia).
Assess clinical status and conduct echocardiogram assessments of left ventricular ejection fraction (LVEF) before and during use and adjust dose accordingly.
Do not initiate if LVEF <55%.
Avoid use in patients treated with disopyramide, ranolazine, verapamil with a β-adrenergic blocking agent, or diltiazem with a β-adrenergic blocking agent; these medications and combinations increase risk of left ventricular systolic dysfunction and heart failure symptoms and clinical experience is limited.
Other Warnings and Precautions
CYP-450 Drug Interactions Leading to Heart Failure or Loss of Effectiveness
Mavacamten primarily metabolized by CYP2C19 and CYP3A4. Concomitant use with other drugs that interact with these enzymes may lead to life-threatening interactions such as heart failure or loss of effectiveness.
Advise patients of potential drug interactions and to report use of all prescription and over-the-counter medications.
Fetal/Neonatal Morbidity and Mortality
Can cause fetal harm based on animal studies. Confirm absence of pregnancy prior to treatment and advise females of reproductive potential to use effective contraception during treatment and for 4 months after the last dose.
Combined hormonal contraceptives containing a combination of ethinyl estradiol and norethindrone are acceptable to use with mavacamten; however, the drug may reduce efficacy of certain other combined hormonal contraceptives. If these contraceptives are used, advise patients to add a nonhormonal contraceptive method (e.g., condoms) during concomitant use and for 4 months after the last dose of mavacamten.
Specific Populations
Pregnancy
Can cause fetal harm.
Report mavacamten exposure to the Bristol Myers Squibb pregnancy registry at 1-800-721-5072 or [Web] if administered during pregnancy, or if pregnancy occurs while taking mavacamten or within 4 months after the last dose.
Lactation
Not known whether mavacamten is distributed into human milk, affects milk production, or affects nursing infants.
Consider developmental and health benefits of breast-feeding along with mother's clinical need for mavacamten, and potential adverse effects on the breast-fed infant from the drug or underlying maternal condition.
Females and Males of Reproductive Potential
Advise females of reproductive potential to use effective contraception during mavacamten treatment and for 4 months after the last dose.
Combined hormonal contraceptives containing a combination of ethinyl estradiol and norethindrone are acceptable to use with mavacamten; however, the drug may reduce efficacy of certain other combined hormonal contraceptives. If these contraceptives are used, advise patients to add a nonhormonal contraceptive method (e.g., condoms) or use an appropriate alternative contraceptive method during concomitant use and for 4 months after the last dose of mavacamten.
Pediatric Use
Safety and efficacy not established.
Geriatric Use
No overall differences in safety, effectiveness, and pharmacokinetics relative to younger patients.
Hepatic Impairment
Exposure increased in patients with mild to moderate hepatic impairment. No additional dose adjustment other than recommended dose titration and monitoring plan is required in patients with mild to moderate hepatic impairment.
Unknown effect of severe hepatic impairment.
Renal Impairment
No clinically significant differences in the pharmacokinetics of mavacamten were observed in patients with mild to moderate (eGFR 30–89 mL/minute per 1.73 m2) renal impairment.
Unknown effects of severe renal impairment or dialysis.
Common Adverse Effects
Adverse effects (>5%): dizziness, syncope.
Drug Interactions
Primarily metabolized by CYP2C19 and to a lesser extent by CYP3A4 and CYP2C9.
Inducer of CYP2B6, CYP3A4, CYP2C9, and CYP2C19.
Does not inhibit CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4 or drug transporters, including p-glycoprotein (P-gp), breast cancer resistance protein (BCRP), bile salt export pump (BSEP), multidrug and toxin exclusion (MATE1), MATE2-K, organic anion transporting polypeptides (OATPs), organic cation transporters (OCTs), or organic anion transporters (OATs).
Drugs Affecting Hepatic Microsomal Enzymes
Strong CYP2C19 inhibitors:concomitant use contraindicated.
Weak CYP2C19 inhibitors or moderate CYP3A4 inhibitors (e.g., verapamil, omeprazole):: may increase mavacamten exposure and risk of adverse effects. Dosage adjustments and additional monitoring required.
Moderate CYP2C19 inhibitors or strong CYP3A4 inhibitors: increase mavacamten exposure and risk of adverse effects. Dosage adjustments and additional monitoring required.
Moderate to strong CYP2C19 inducers or moderate to strong CYP3A4 inducers: Concomitant use contraindicated.
Drugs Metabolized by Hepatic Microsomal Enzymes
Exposure and activity of CYP3A4, CYP2C9, or CYP2C19 substrates can be reduced by mavacamten. Closely monitor patients receiving mavacamten in combination with CYP3A4, CYP2C19, or CYP2C9 substrates where decreases in the plasma concentration of the substrate drug may reduce its activity.
Drugs That Reduce Cardiac Contractility
Additive negative inotropic effects with concomitant use of other drugs that reduce cardiac contractility.
Avoid concomitant use of disopyramide, ranolazine, verapamil with a β-adrenergic blocking agent, or diltiazem with a β-adrenergic blocking agent; these medications and combinations increase risk of left ventricular systolic dysfunction and heart failure symptoms and clinical experience is limited. If a negative inotrope is initiated or the dose of a negative inotrope is increased, monitor LVEF closely until stable doses and clinical response are attained.
Specific Drugs
Drug |
Interaction |
Comments |
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Calcium-channel blocking agents (diltiazem, verapamil) |
Diltiazem: Predicted increased AUC of mavacamten by 55% and peak plasma concentrations by 42% in CYP2C19 poor metabolizers Verapamil: Increased AUC of mavacamten by 16% and peak plasma concentrations by 52% in intermediate and normal CYP2C19 metabolizers |
For patients on stable therapy with a moderate CYP3A4 inhibitor, initiate mavacamten at 5 mg once daily For patients starting moderate CYP3A4 inhibitor while taking mavacamten, reduce mavacamten dose by one dose level (i.e., reduce 15 mg to 10 mg; 10 mg to 5 mg; 5 mg to 2.5 mg) For patients on mavacamten 2.5 mg once daily, avoid initiation of moderate CYP3A4 inhibitors For short-term use (e.g., 1 week), interrupt mavacamten for the duration of treatment with a moderate CYP3A4 inhibitor; may reinitiate at previous dose immediately upon discontinuation of concomitant therapy. |
Hormonal contraceptives (ethinyl estradiol/progestin) |
Possible decreased exposure of certain progestins leading to possible contraceptive failure Combined hormonal contraceptives containing a combination of ethinyl estradiol and norethindrone are acceptable to use with mavacamten; however, mavacamten may reduce efficacy of certain other combined hormonal contraceptives. |
Advise females of reproductive potential to use effective contraception during mavacamten treatment and for 4 months after the last dose. If certain combined hormonal contraceptives are used, advise patients to add a nonhormonal contraceptive method (e.g., condoms) or use an acceptable alternative contraceptive method during concomitant use and for 4 months after last dose of mavacamten |
Ketoconazole |
Predicted increased AUC of mavacamten up to 130% and peak plasma concentrations by 90% in CYP2C19 poor metabolizers |
For patients on stable therapy with a strong CYP3A4 inhibitor, initiate mavacamten at 2.5 mg once daily For patients starting strong CYP3A4 inhibitor while taking mavacamten, reduce mavacamten dose by one dose level (i.e., reduce 15 mg to 10 mg; 10 mg to 5 mg; 5 mg to 2.5 mg) For patients on mavacamten 2.5 mg once daily, avoid initiation of strong CYP3A4 inhibitors An increase in mavacamten dose may be necessary if the strong CYP3A4 inhibitor is discontinued after long-term concomitant use For short-term use (e.g., 1 week), interrupt mavacamten for the duration of treatment with a strong CYP3A4 inhibitor; may reinitiate at previous dose immediately upon discontinuation of concomitant therapy. |
Midazolam |
Decreased AUC of midazolam by 13% and peak plasma concentrations by 7% in CYP2C19 normal metabolizers |
Monitor for reduced efficacy of midazolam |
Omeprazole |
Omeprazole, a weak CYP2C19 inhibitor and CYP2C19 substrate, increased AUC of mavacamten by 48%; no effect on peak plasma concentrations in normal and rapid CYP2C19 metabolizers Predicted decrease in AUC and peak plasma concentrations of omeprazole by up to 48% and 17%, respectively, depending on mavacamten dose and CYP2C19 phenotype |
For patients on stable therapy with a weak CYP2C19 inhibitor, initiate mavacamten at 5 mg once daily For patients starting on a weak CYP2C19 inhibitor while taking mavacamten, reduce mavacamten dose by one dosage level (i.e., reduce 15 to 10 mg; 10 to 5 mg; 5 to 2.5 mg) For patients on mavacamten 2.5 mg once daily, avoid initiation of weak CYP2C19 inhibitors For short-term use (e.g., 1 week), interrupt mavacamten for the duration of treatment with a weak CYP2C19 inhibitor; may reinitiate at previous dose immediately upon discontinuation of concomitant therapy Monitor for reduced efficacy of omeprazole |
Repaglinide |
Predicted decrease in AUC and peak plasma concentrations of repaglinide by up to 27% and 19%, respectively, depending on mavacamten dose and CYP2C19 phenotype |
Monitor for reduced efficacy of repaglinide |
Rifampin |
Predicted decreased AUC of mavacamten by 87% and peak plasma concentrations by 22% in CYP2C19 normal metabolizers and by 69% and 4%, respectively in CYP2C19 poor metabolizers |
Concomitant use is contraindicated |
Tolbutamide |
Predicted decrease in AUC and peak plasma concentration of tolbutamide, a CYP2C9 substrate, by up to 54 and 23%, respectively, depending on mavacamten dose and CYP2C19 phenotype |
Monitor for reduced efficacy of tolbutamide |
Mavacamten Pharmacokinetics
Absorption
Bioavailability
Estimated oral bioavailability at least 85%.
Peak plasma concentrations achieved in about 1 hour
Food
No clinically relevant effect on pharmacokinetics after a high fat meal; time to peak plasma concentrations increased by 4 hours.
Distribution
Extent
Not known whether distributed into human milk.
Plasma Protein Binding
97–98%.
Elimination
Metabolism
Extensively metabolized; primarily through CYP2C19 and to a lesser extent through CYP3A4 and CYP2C9.
CYP2C19 poor metabolizers: AUC increased by 241% and peak plasma concentration increased by 47%.
Elimination Route
Urine: 85% (3% unchanged).
Feces: 7% (1% unchanged).
Half-life
CYP2C19 normal metabolizers: 6 to 9 days
CYP2C19 poor metabolizers: 23 days
Special Populations
Mild and moderate hepatic impairment (Child-Pugh class A and B): Exposure is increased.
Severe hepatic impairment (Child-Pugh class C): Unknown effect.
Mild to moderate renal impairment (eGFR 30–89 mL/min per 1.73 m2): No clinically significant changes in pharmacokinetics. Severe renal impairment (eGFR 15–30 mL/minute per 1.73 m2) and dialysis: Unknown effect.
Stability
Storage
Oral
Capsules
20–25°C (excursions permitted to 15–30°C).
Actions
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Allosteric and reversible inhibitor selective for cardiac myosin; targets the underlying sarcomere hypercontractility of HCM.
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Reduces myocardial contractility by decreasing actin-myosin cross-bridge formation.
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Shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state.
Advice to Patients
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Advise patients and/or their caregivers to read the FDA-approved patient labeling (Medication Guide).
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Advise patients that if they miss a dose of mavacamten, to take the dose as soon as possible that day and to take the next scheduled dose at the usual time the following day. The patient should not take 2 doses in the same day.
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Inform patients that cardiac function monitoring must be performed using echocardiography to monitor for heart failure. Advise patients to report any signs or symptoms of heart failure immediately to their healthcare provider.
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Advise patients to notify their healthcare provider if they develop serious infection or arrhythmia, which may require interruption of mavacamten therapy.
-
Inform patients that mavacamten is available only through a restricted program called the Camzyos REMS Program. Advise patients of the need to enroll and comply with monitoring requirements of the program.
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Advise patients of the potential risk to a fetus. Advise females of reproductive potential to inform their healthcare provider of a known or suspected pregnancy.
-
Advise females of reproductive potential to use effective contraception during treatment with mavacamten and for 4 months after the last dose. Combined hormonal contraceptives containing a combination of ethinyl estradiol and norethindrone are acceptable to use with mavacamten; however, the drug may reduce efficacy of certain other combined hormonal contraceptives. If these contraceptives are used, advise patients to add a nonhormonal contraceptive method (e.g., condoms) or use an acceptable alternative contraceptive method during concomitant use and for 4 months after the last dose of mavacamten.
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Advise females who are exposed to mavacamten during pregnancy that there is a pregnancy safety study that monitors pregnancy outcomes. Encourage these patients to report their pregnancies to Bristol-Myers Squibb at 1-800-721-5072.
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Advise patients to inform their clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.
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Inform patients of other important precautionary information.
Additional Information
The American Society of Health-System Pharmacists, Inc. represents that the information provided in the accompanying monograph was formulated with a reasonable standard of care, and in conformity with professional standards in the field. Readers are advised that decisions regarding use of drugs are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and that the information contained in the monograph is provided for informational purposes only. The manufacturer’s labeling should be consulted for more detailed information. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information contained in the monograph is not a substitute for medical care.
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
Mavacamten is only available through a restricted program called the Camzyos REMS Program because of the risk of heart failure due to systolic dysfunction.
Routes |
Dosage Forms |
Strengths |
Brand Names |
Manufacturer |
---|---|---|---|---|
Oral |
Capsules |
2.5 mg |
Camzyos |
Bristol Myers Squibb |
5 mg |
Camzyos |
Bristol Myers Squibb |
||
10 mg |
Camzyos |
Bristol Myers Squibb |
||
15 mg |
Camzyos |
Bristol Myers Squibb |
AHFS DI Essentials™. © Copyright 2025, Selected Revisions September 10, 2025. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.
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