Generic Name: etoposide phosphate (e TOE poe side FOS fate)
Brand Name: Etopophos
What is etoposide phosphate?
Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.
Etoposide phosphate is used to treat cancer of the lung or testicles.
Etoposide phosphate may also be used for purposes not listed in this medication guide.
What is the most important information I should know about etoposide phosphate?
Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
While being treated with etoposide phosphate, use birth control to prevent pregnancy, whether you are a man or a woman. Tell your doctor right away if a pregnancy occurs while either parent is using etoposide phosphate.
What should I discuss with my health care provider before using etoposide phosphate?
You should not use this medication if you are allergic to etoposide.
To make sure etoposide phosphate is safe for you, tell your doctor if you have:
a weak immune system (from disease or from taking certain medicines); or
a condition for which you take warfarin (Coumadin, Jantoven).
Using etoposide phosphate during pregnancy could harm the unborn baby. Use birth control to prevent pregnancy, whether you are a man or a woman. Etoposide phosphate use by either parent may cause birth defects.
For women: Use effective birth control while you are using etoposide phosphate and for at least 6 months after your last dose.
For men: Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 4 months after you stop using etoposide phosphate.
Tell your doctor right away if a pregnancy occurs while either parent is using etoposide phosphate.
This medicine may affect fertility (your ability to have children), whether you are a man or a woman.
It is not known whether etoposide phosphate passes into breast milk or if it could affect the nursing baby. You should not breast-feed while you are being treated with etoposide phosphate.
Using etoposide phosphate may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.
How is etoposide phosphate given?
Etoposide phosphate is injected into a vein through an IV. A healthcare provider will give you this injection.
Etoposide phosphate is usually given for 4 or 5 days in a row every 3 to 4 weeks. Follow your doctor's instructions.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when etoposide phosphate is injected.
Etoposide phosphate can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your etoposide phosphate injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving etoposide phosphate?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using etoposide phosphate, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Etoposide phosphate side effects
Get emergency medical help if you have signs of an allergic reaction: fever, chills, sweating, fast heartbeats, fainting; hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pain, burning, irritation, or skin changes where the injection was given;
severe nausea and vomiting;
low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, easy bruising, unusual bleeding, feeling light-headed; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
trouble swallowing; or
unusual or unpleasant taste in the mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Etoposide phosphate dosing information
Usual Adult Dose for Testicular Cancer:
50 to 100 mg/m2 IV once a day over 5 minutes to 3.5 hours on days 1 through 5 of each 21-day (or 28-day cycle)
100 mg/m2 IV once a day over 5 minutes to 3.5 hours on days 1, 3, and 5 of each 21-day (or 28-day cycle)
Use: For treatment of patients with refractory testicular tumors (in combination with other chemotherapeutic drugs)
Usual Adult Dose for Small Cell Lung Cancer:
35 to 50 mg/m2 IV once a day over 5 minutes to 3.5 hours for 4 days
50 mg/m2 IV once a day over 5 minutes to 3.5 hours for 5 days
Use: For first-line treatment of patients with small cell lung cancer (in combination with cisplatin)
What other drugs will affect etoposide phosphate?
Other drugs may interact with etoposide phosphate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
See also: Side effects (in more detail)
More about etoposide
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- 0 Reviews – Add your own review/rating
- Drug class: mitotic inhibitors
- Etoposide Capsules
- Etoposide Injection
- Etoposide Phosphate
- Etoposide (Advanced Reading)
- Etoposide Oral, Intravenous (Advanced Reading)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about etoposide phosphate.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 5.06.
Date modified: September 05, 2017
Last reviewed: March 15, 2017