Chlorpheniramine, dextromethorphan, and phenylephrine
Generic name: chlorpheniramine, dextromethorphan, and phenylephrine (klor feh NEER a meen, dex troe meh THOR fan, and feh nill EH frin)
Brand name: Alka-Seltzer Plus Cold and Cough, Balamine DM, Ed A-Hist DM, Gencontuss, Giltuss Allergy Plus, NoHist DM, Robitussin Cough & Allergy, ...show all 73 brand namesCerose DM, Tussar DM, Liquituss R-DM, Atuss DM, Norel DM, Poly-Tussin DM, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Rondec-DM Drops, Rondec-DM, Donatussin DM Drops, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Cardec DM Drops, Reme Tussin DM, Maxiphen ADT, Tussplex DM, Robitussin Pediatric Cough and Cold Nighttime, Robitussin Cough and Allergy, Robitussin Cough and Cold Nighttime, Cardec DM, C-Phen DM, C-Phen DM Drops, Sildec-PE DM Drops, Sildec-PE DM, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Nohist-DMX, Sonahist-DM, Relahist-DM, Z-Dex 12 D, Bronkids, Statuss DM, Albatussin SR, NoHist-PDX, Re DCP, Centergy DM, Zoden DM Drops, Trigofen DM Drops, Nasohist-DM Pediatric, Tri-Dex PE, Virdec DM, Norel CS, EndaCof Drops, Giltuss Children's Allergy Plus
Dosage forms: oral liquid (2 mg-10 mg-5 mg/5 mL; 4 mg-15 mg-10 mg/5 mL; 4 mg-20 mg-10 mg/10 mL); oral tablet, effervescent (2 mg-10 mg-5 mg)
Drug class: Upper respiratory combinations
What is chlorpheniramine, dextromethorphan, and phenylephrine?
Chlorpheniramine, dextromethorphan, and phenylephrine is a combination medicine used to treat cough, runny or stuffy nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.
Chlorpheniramine, dextromethorphan, and phenylephrine may also be used for purposes not listed in this medication guide.
Before taking this medicine
Ask a doctor or pharmacist if this medicine is safe to use if you have:
asthma or COPD, cough with mucus;
a blockage in your digestive tract (stomach or intestines);
high blood pressure, heart disease;
liver or kidney disease;
enlarged prostate or urination problems;
overactive thyroid; or
pheochromocytoma (an adrenal gland tumor).
Do not use chlorpheniramine, dextromethorphan, and phenylephrine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
How should I take chlorpheniramine, dextromethorphan, and phenylephrine?
Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.
Always follow directions on the medicine label about giving cough or cold medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of cough or cold medicines in very young children.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Dissolve the effervescent tablets in at least 4 ounces of water. Stir and drink this mixture right away. Add a little more water to the glass, swirl gently and drink right away.
Do not take for longer than 7 days in a row. Call your doctor if your symptoms do not improve after 7 days, or if you have a fever, rash, or headaches.
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since chlorpheniramine, dextromethorphan, and phenylephrine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
hat should I avoid while taking chlorpheniramine, dextromethorphan, and phenylephrine?
Drinking alcohol with this medicine can cause side effects.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.
Avoid becoming overheated or dehydrated during exercise and in hot weather. This medicine can decrease sweating and you may be more prone to heat stroke.
chlorpheniramine, dextromethorphan, and phenylephrine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
severe anxiety, tremor, seizure (convulsions);
fast or pounding heartbeats;
painful or difficult urination;
pale skin, weakness; or
severe headache, pounding in your neck or ears.
Common side effects may include:
dry mouth, nose, or throat;
increased or decreased urination;
sleep problems (insomnia); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect chlorpheniramine, dextromethorphan, and phenylephrine?
Avoid using this medicine with other drugs that cause drowsiness or slow your breathing (such as opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Ask a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed in this medication guide.
More about chlorpheniramine / dextromethorphan / phenylephrine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- 5 Reviews
- Drug class: upper respiratory combinations
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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