Chlorpheniramine, dextromethorphan, and phenylephrine
Generic Name: chlorpheniramine, dextromethorphan, and phenylephrine (klor feh NEER a meen, dex troe meh THOR fan, and feh nill EH frin)
Brand Name: Alka-Seltzer Plus Cold and Cough, Cardec DM Drops, Corfen-DM, De-Chlor DM, DM-PE-Chlor, Ed A-Hist DM, Nasohist-DM Pediatric, NoHist DM, Norel CS, Poly-Tussin DM, Robitussin Cough & Allergy, Robitussin Pediatric Cough & Cold Nighttime, Tri-Dex PE, Trigofen DM Drops, Virdec DM, Zoden DM Drops, ...show all 72 brand namesCerose DM, Tussar DM, Liquituss R-DM, Atuss DM, Norel DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Rondec-DM Drops, Rondec-DM, Donatussin DM Drops, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Reme Tussin DM, Maxiphen ADT, Tussplex DM, Robitussin Pediatric Cough & Cold Nighttime, Robitussin Cough & Allergy, Robitussin Cough & Cold Nighttime, Cardec DM, C-Phen DM, C-Phen DM Drops, Sildec-PE DM Drops, Sildec-PE DM, Nasohist-DM, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Nohist-DMX, Sonahist-DM, Relahist-DM, Z-Dex 12 D, Bronkids, Statuss DM, Albatussin SR, NoHist-PDX, Re DCP, Centergy DM, EndaCof Drops, Balamine DM, Gencontuss
Medically reviewed on November 20, 2017
What is chlorpheniramine, dextromethorphan, and phenylephrine?
Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Chlorpheniramine, dextromethorphan, and phenylephrine is a combination medicine used to treat cough, runny or stuffy nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu.
Chlorpheniramine, dextromethorphan, and phenylephrine may also be used for purposes not listed in this medication guide.
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Before taking this medicine
Do not use chlorpheniramine, dextromethorphan, and phenylephrine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
To make sure chlorpheniramine, dextromethorphan, and phenylephrine is safe for you, tell your doctor if you have:
a blockage in your digestive tract (stomach or intestines);
high blood pressure, heart disease;
liver or kidney disease;
cough with mucus, or cough caused by emphysema or chronic bronchitis;
enlarged prostate or urination problems;
pheochromocytoma (an adrenal gland tumor);
overactive thyroid; or
FDA pregnancy category C. It is not known whether chlorpheniramine, dextromethorphan, and phenylephrine will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.
This medicine can pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.
How should I take chlorpheniramine, dextromethorphan, and phenylephrine?
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.
Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Dissolve the effervescent tablets in at least 4 ounces of water. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Since chlorpheniramine, dextromethorphan, and phenylephrine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking chlorpheniramine, dextromethorphan, and phenylephrine?
Drinking alcohol can increase certain side effects of chlorpheniramine, dextromethorphan, and phenylephrine.
Ask a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Antihistamines and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or cough suppressant.
This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Chlorpheniramine and phenylephrine can decrease sweating and you may be more prone to heat stroke.
Chlorpheniramine, dextromethorphan, and phenylephrine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using chlorpheniramine, dextromethorphan, and phenylephrine and call your doctor at once if you have:
severe anxiety or restless feeling, hallucinations, tremor, seizure (convulsions);
fast or pounding heartbeats;
painful or difficult urination, little or no urinating;
pale skin, weakness; or
increased blood pressure--severe headache, buzzing in your ears, chest pain, shortness of breath, uneven heartbeats.
Common side effects may include:
dizziness, drowsiness, double vision, mild headache;
sleep problems (insomnia); or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect chlorpheniramine, dextromethorphan, and phenylephrine?
Tell your doctor about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.
Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking chlorpheniramine, dextromethorphan, and phenylephrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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