Generic Name: carfilzomib (kar FILZ oh mib)
Brand Name: Kyprolis
Medically reviewed on July 31, 2018
What is carfilzomib?
Carfilzomib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Carfilzomib is used to treat multiple myeloma. Carfilzomib is sometimes given with other medicines when treating relapsed multiple myeloma.
Carfilzomib is usually given after other treatments have failed.
Carfilzomib may also be used for purposes not listed in this medication guide.
Carfilzomib can affect your heart or lungs. Call your doctor at once if you have chest pain, pounding heartbeats, shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet, feeling like you might pass out, wheezing, gasping for breath, cough with foamy mucus, or blue colored appearance of your lips and skin.
Before taking this medicine
You should not use carfilzomib if you are allergic to it.
Tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
heart disease, high blood pressure; or
Carfilzomib can harm an unborn baby or cause birth defects if the mother or the father is using carfilzomib.
If you are a woman, do not use carfilzomib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 30 days after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 90 days after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using carfilzomib.
You should not breast-feed while using carfilzomib.
How is carfilzomib given?
Carfilzomib is given as an infusion into a vein. A healthcare provider will give you this injection.
Carfilzomib is given in a 28-day treatment cycle. You will receive an injection only on certain days of this cycle.
Drink plenty of liquids before and after your carfilzomib injections.
You may be given other medications to help prevent serious side effects or infections. Keep using these medicines for as long as your doctor has prescribed.
You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your carfilzomib injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving carfilzomib?
Avoid driving or hazardous activity until you know how carfilzomib will affect you. Your reactions could be impaired.
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Carfilzomib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur within 24 hours after the injection. Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, feverish, sweaty, or if you have joint or muscle pain, a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Call your doctor at once if you have:
shortness of breath (even while lying down), wheezing, blue colored lips and skin, cough with foamy mucus;
a light-headed feeling, like you might pass out;
easy bruising, unusual bleeding, or any bleeding that will not stop;
headache, confusion, change in mental status, vision loss, seizure (convulsions);
vomiting, diarrhea, weakness, blood in your stools, coughing up blood or vomit that looks like coffee grounds;
jaundice (yellowing of the skin or eyes);
heart problems--chest pain, pain spreading to your jaw or shoulder, pounding in your neck or ears, blurred vision, anxiety;
kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, pale skin, cold hands and feet;
signs of a blood clot--sudden numbness or weakness, slurred speech, pain or redness in an arm or leg; or
Common side effects may include:
fever, bruising, pale skin or other signs of low blood cell counts;
swelling in your hands or feet; or
headache, trouble sleeping, feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect carfilzomib?
Other drugs may affect carfilzomib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.01.
More about carfilzomib
- Carfilzomib Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 2 Reviews
- Drug class: proteasome inhibitors
Other brands: Kyprolis