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Avibactam and cefTAZidime

Generic Name: avibactam and ceftazidime (AV i BAK tam and sef TAZ i deem)
Brand Name: Avycaz

Medically reviewed by Drugs.com on Oct 23, 2018 – Written by Cerner Multum

What is avibactam and ceftazidime?

Avibactam and ceftazidime is a combination antibiotic medicine that is used in adults to treat complicated infections of the bladder, kidney, lungs, or stomach and intestines.

Avibactam and ceftazidime is also used to prevent certain types of bacteria from becoming resistant to antibiotic medication.

Avibactam and ceftazidime may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use avibactam and cefTAZidime if you are allergic to avibactam or ceftazidime, or to a cephalosporin antibiotic such as:

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breast-feeding.

Avibactam and ceftazidime is not approved for use by anyone younger than 18 years old.

How is avibactam and ceftazidime given?

Avibactam and ceftazidime is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

This medicine must be given slowly, and the infusion can take at least 2 hours to complete. You may need to use this medicine for up to 14 days. Follow your doctor's dosing instructions very carefully.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Avibactam and ceftazidime must be mixed with a liquid (diluent) in an IV bag. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

After mixing, store the IV bag at room temperature and use it within 12 hours.

You may also store the IV bag in a refrigerator for up to 24 hours. Do not freeze. After you take the IV bag out of the refrigerator, you must use it within 12 hours.

Do not use avibactam and ceftazidime if it has changed colors or has particles in it. Call your pharmacist for new medication. The mixture should appear clear to light yellow.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Avibactam and ceftazidime will not treat a viral infection such as the flu or a common cold.

Call your doctor if your symptoms do not improve, or if they get worse.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using avibactam and ceftazidime.

Store unmixed avibactam and ceftazidime at room temperature away from moisture, heat, and light.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of avibactam and ceftazidime.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using avibactam and ceftazidime?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Avibactam and ceftazidime side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • a seizure (convulsions);

  • rigid muscles, overactive reflexes;

  • confusion, hallucinations; or

  • a change in your mental state.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avibactam and cefTAZidime dosing information

Usual Adult Dose for Intraabdominal Infection:

2.5 g IV every 8 hours
Duration of therapy: 5 to 14 days

Comments:
-Metronidazole should be used concomitantly.

Use: In combination with metronidazole, for the treatment of complicated intraabdominal infections due to the following susceptible gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, K oxytoca, Citrobacter freundii complex, Pseudomonas aeruginosa

Usual Adult Dose for Pyelonephritis:

2.5 g IV every 8 hours
Duration of therapy: 7 to 14 days

Uses:
-For the treatment of complicated urinary tract infections (including pyelonephritis) due to the following susceptible gram-negative microorganisms: E coli, K pneumoniae, E cloacae, C freundii complex, P mirabilis, P aeruginosa
-For the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia due to K pneumoniae, E cloacae, E coli, Serratia marcescens, P mirabilis, P aeruginosa, Haemophilus influenzae

Usual Adult Dose for Urinary Tract Infection:

2.5 g IV every 8 hours
Duration of therapy: 7 to 14 days

Uses:
-For the treatment of complicated urinary tract infections (including pyelonephritis) due to the following susceptible gram-negative microorganisms: E coli, K pneumoniae, E cloacae, C freundii complex, P mirabilis, P aeruginosa
-For the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia due to K pneumoniae, E cloacae, E coli, Serratia marcescens, P mirabilis, P aeruginosa, Haemophilus influenzae

Usual Adult Dose for Nosocomial Pneumonia:

2.5 g IV every 8 hours
Duration of therapy: 7 to 14 days

Uses:
-For the treatment of complicated urinary tract infections (including pyelonephritis) due to the following susceptible gram-negative microorganisms: E coli, K pneumoniae, E cloacae, C freundii complex, P mirabilis, P aeruginosa
-For the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia due to K pneumoniae, E cloacae, E coli, Serratia marcescens, P mirabilis, P aeruginosa, Haemophilus influenzae

What other drugs will affect avibactam and ceftazidime?

Other drugs may affect avibactam and ceftazidime, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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