Generic Name: apomorphine (a poe MOR feen)
Brand Name: Apokyn, APO-Go, APO-Go Pen, Uprima
What is apomorphine?
Apomorphine is used to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with advanced Parkinson's disease.
Apomorphine may also be used for purposes not listed in this medication guide.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
You should not use apomorphine if you are allergic it.
Many drugs can interact and cause dangerous effects. Some drugs should not be used together with apomorphine. Your doctor may change your treatment plan if you also use:
Tell your doctor if you have ever had:
asthma or a sulfite allergy;
low blood pressure or dizzy spells;
narcolepsy, falling asleep during the daytime;
liver or kidney disease;
mental illness or psychosis; or
if you drink alcohol.
Tell your doctor if you are pregnant or breastfeeding.
How should I use apomorphine?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Apomorphine is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.
Do not inject apomorphine into a vein.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.
Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.
Measuring your dose correctly is extremely important. The dose in an apomorphine injection pen is measured in milliliters (mL) marked on the pen. However, your prescribed dose may be in milligrams (mg). One milligram, or 1 mg, of apomorphine is equal to 0.1 mL marked on the injection pen.
Your care provider will show you where to on your body to inject apomorphine. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
You may be given other medications to help prevent nausea and vomiting. Use only the anti-nausea medicine prescribed by your doctor. Some anti-nausea medicines can increase certain side effects of apomorphine, or can make your Parkinson's symptoms worse.
Your blood pressure will need to be checked often.
The medicine from an apomorphine injection pen can cause irritation if it gets in your eyes or on your skin. If this happens, rinse with water.
Do not stop using apomorphine suddenly, or you could have unpleasant withdrawal symptoms such as fever and confusion. Ask your doctor how to safely stop using apomorphine.
If you stop using apomorphine for 7 days or longer, ask your doctor before restarting the medication. You may need to restart with a lower dose.
Store apomorphine cartridges at room temperature away from moisture and heat.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. Allow at least 2 hours to pass between doses.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using apomorphine?
Some people using apomorphine have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Avoid driving or operating machinery until you know how apomorphine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Do not drink alcohol. It can further lower your blood pressure and may increase certain side effects of apomorphine.
Apomorphine side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
ongoing nausea or vomiting (even after taking anti-nausea medicine);
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
worsening of your Parkinson symptoms;
chest pain, fast or slow heart beats, shortness of breath;
a light-headed feeling, like you might pass out;
daytime sleepiness or drowsiness;
confusion, hallucinations, unusual thoughts or behavior;
new or worsening cough, fever, pain when you breathe, feeling short of breath while lying down;
unexplained pain in your stomach, back, or leg;
swelling in your lower legs; or
penis erection that is painful or lasts 4 hours or longer.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while using this medicine. Talk with your doctor if this occurs.
Common side effects may include:
runny nose; or
itching, bruising, or swelling where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect apomorphine?
If you also take nitroglycerin (under the tongue), your blood pressure may drop and you may feel dizzy. Lie down for at least 45 minutes if possible.
Tell your doctor about all your current medicines. Many drugs can affect apomorphine, especially:
heart or blood pressure medication;
medicine to treat or prevent nausea and vomiting; or
medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia.
This list is not complete and many other drugs may affect apomorphine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.
More about apomorphine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
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- Drug class: dopaminergic antiparkinsonism agents
Other brands: Apokyn