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Can Xolair be self-administered at home?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 21, 2024.

Official Answer by Drugs.com

Yes, you or your caregiver can learn how to give Xolair at home if you and your doctor agree that self-injection is appropriate.

You will receive training on how to inject this medicine from your healthcare team. At first, you will receive the medication from your doctor in a healthcare setting. This allows your doctor to monitor you and treat you for side effects like a severe allergic reaction (anaphylaxis), if this should occur.

Anaphylaxis is a life-threatening condition and can lead to death. Learn how to recognize anaphylaxis and talk to your doctor about how to identify the symptoms. Go to the nearest emergency room or call 911 right away if you have any of these symptoms of an allergic reaction:

What is Xolair approved to treat?

Xolair (omalizumab) injection is approved to treat:

Xolair is given by 1 or more injections under the skin (subcutaneously). It is given once every 2 or 4 weeks. Your doctor will determine your exact dose.

Use Xolair exactly as directed by your healthcare provider. Do not use the injection until you have been trained on how to do this. Once you have been trained, you can follow the detailed “Instructions for Use” that comes with your medicine to administer at home. If you have questions, contact your healthcare provider or pharmacist.

Related: See the Xolair “Instructions for Use” under Patient Counseling Information.

This is not all the information you need to know about Xolair (omalizumab) for safe and effective use and does not take the place of your healthcare provider's directions. Review the product information and discuss any questions you have with your doctor, pharmacist or other health care provider.

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How does Xolair work?

Xolair works by preventing IgE from binding to IgE receptors on mast cells and basophils. This prevents mast cells and basophils from releasing histamine and heparin. Histamine narrows smooth muscle in the airways making it harder to breathe and also causes tissue swelling, itchy skin, hives, and other allergic-type symptoms. Heparin makes it harder for blood to clot. Continue reading

Does Xolair cause weight gain?

There were no reports of weight gain or weight loss in clinical trials with Xolair. Weight gain is more likely to be caused by corticosteroids, hydroxyzine, or antihistamines that may also be used to treat allergic asthma or hives. Continue reading

What is omalizumab's mechanism of action?

The omalizumab mechanism of action is designed to target IgE (immunoglobulin E), an antibody produced by the immune system. It works by inhibiting the binding of the IgE antibody to IgE receptors on cells that can lead to inflammation and worsened allergic symptoms. Continue reading

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