Does Xcopri cause weight gain or weight loss?
Will Xcopri tablets (cenobamate) cause me to gain weight or lose weight?
Yes, Xcopri can cause weight loss for a small percentage of users. In clinical trials up to 2% of patients experienced weight loss, and up to 5% of patients had decreased appetite. Most people will not see a change in weight.
Xcopri (cenobamate) is FDA approved medicine used for the treatment of partial-onset seizures in adult patients.
Medicines used to treat seizures (also called antiepileptic drugs or anticonvulsants) are usually taken long term so side effects of significant weight gain or weight loss overtime can cause marked health issues. Usually weight gain or weight loss only affects a small percentage of patients.
The antiepileptic drugs (AEDs) are sometimes divided into groups by how they may affect weight.
Antiepileptic drugs that may cause:
weight gain:
- gabapentin
- pregabalin
- valproic acid
- vigabatrin
- possibly carbamazepine
weight neutral:
- lamotrigine,
- levetiracetam
- phenytoin
slight weight loss:
- felbamate
strong weight loss:
- topiramate
- zonisamide
If you are concerned about weight loss or weight gain may be due to your medication it is important to discuss this with your doctor.
Note: You should not to discontinue taking Xcopri or other antiepileptic drugs without consulting with your healthcare provider.
For more information on Xcopri click here: Xcopri Medication Information
References
- Xcopri Prescribing Information: [Accessed October 20, 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/212839s006s007lbl.pdf
- Weight issues for people with epilepsy--a review: [Accessed October 20, 2022] https://pubmed.ncbi.nlm.nih.gov/18047602/
- Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide: [Accessed October 20, 2022] https://pubmed.ncbi.nlm.nih.gov/22249827/#:~:text=Several%20antiepileptic%20drugs%20(AEDs)%20are,loss%20as%2C%20e.g.%2C%20felbamate.
Read next
Is Xcopri a controlled substance?
Xcopri (generic name: cenobamate) is a schedule 5 controlled substance (CV) first approved in 2019. It is an oral tablet used for the treatment of partial-onset seizures in adult patients with epilepsy. Xcopri is classified as a controlled substance by the DEA because it may be habit-forming and lead to abuse or dependence. Continue reading
Is obesity a major risk factor for Covid-19?
Obesity is a major risk factor for covid-19 and people who are obese are more likely than those who are not obese to contract Covid-19 at a younger age, develop severe Covid-19, require hospitalization, oxygen, mechanical ventilation, intubation, or admission into ICU, end up in hospital sooner, or die from Covid-19. Continue reading
Mounjaro vs Ozempic: Which is right for you?
Mounjaro and Ozempic are prescription medicines used alongside diet and exercise to help control blood sugar (glucose) levels in adults with type 2 diabetes. Ozempic is also approved to lower the risk of a major cardiovascular event (like a heart attack or stroke) in patients with type 2 diabetes, as well as to reduce the risk of worsening kidney disease and heart-related death in patients with type 2 diabetes. Mounjaro has not yet received these indications, although studies are ongoing.
In a large, 2024 retrospective study in adults with overweight or obesity and treated for type 2 diabetes, Mounjaro led to at least a 5% weight loss within one year in 81.8% of adults compared to 66.5% of those using Ozempic. Continue reading
See also:
Related medical questions
- Zepbound vs Mounjaro: Comparison Guide for Weight Loss and Diabetes Treatment
- Ozempic Side Effects to Watch For
- Why am I not losing weight on Mounjaro?
- Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared
- Wegovy vs Ozempic: Which is Right for You?
- How long does it take for Ozempic to work?
- How long until I'll lose weight with Wegovy?
- Does levothyroxine cause weight gain or loss?
- Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?
- Which GLP-1 drug is best for weight loss?
- How does Ozempic work for weight loss?
- Tirzepatide vs semaglutide: How do they compare?
- Does Wellbutrin XL/SR cause weight gain or loss?
- Why does Lexapro cause weight gain? Complete Patient Guide
- Does Ozempic need to be refrigerated?
- Does Lyrica (pregabalin) cause weight gain?
- How much is Zepbound with or without insurance?
- What happens when you stop taking Ozempic?
- Does gabapentin cause weight gain?
- Does Zoloft (sertraline) cause weight gain?
- Will my insurance cover the cost of Ozempic?
- How long does it take for Zepbound to work?
- How does Mounjaro Work for Weight Loss?
- Saxenda vs Ozempic: For Weight Loss?
- Does Prozac cause weight gain or loss?
- How effective is Topamax (topiramate) for weight loss?
- Can you get tirzepatide from a compounding pharmacy?
- Why am I not losing weight on Ozempic?
Drug information
Related support groups
- Xcopri (4 questions, 4 members)
- Cenobamate (1 questions, 3 members)
- Weight Loss (Obesity/Overweight) (875 questions, 1,514 members)
- Weight Loss (Underweight) (21 questions, 824 members)
- Seizures (162 questions, 795 members)