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What is the difference between Spikevax and mNEXSPIKE?

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 2, 2025.

Official Answer by Drugs.com

Moderna has developed mNEXSPIKE, a next-generation COVID-19 vaccine that uses only one-fifth the dose of their current Spikevax vaccine. This lower dose is possible due to a more targeted design that creates a focused immune response.

Key Differences Between Spikevax and mNEXSPIKE

Vaccine Technology:

Spikevax:

mNEXSPIKE:

Eligibility:

Spikevax:

mNEXSPIKE:

Related questions

Effectiveness:

Clinical trials showed:

Practical Differences:

Storage:

Dosing:

Bottom Line

mNEXSPIKE is a next-generation vaccine that targets specific parts of the spike protein, allowing for a much lower dose while potentially providing better immune responses.

References

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