How are Symdeko tablets taken?
Symdeko (tezacaftor/ivacaftor tablets and ivacaftor tablets) is a cystic fibrosis (CF) treatment that is taken twice a day.
Symdeko is indicated for use in cystic fibrosis patients ages 6 years and older who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with Symdeko.
Symdeko is supplied as co-packaged tablets in two strengths:
- tezacaftor 50 mg/ivacaftor 75 mg (white tablet) with ivacaftor 75 mg (light blue tablet)
(for patients ages 6 to 11 years weighing less than 30 kg) - tezacaftor 100 mg/ivacaftor 150 mg (yellow tablet) with ivacaftor 150 mg (light blue tablet)
(for patients ages 6 to 11 years weighing more than 30 kg or ages 12 years and older)
The Symdeko package contains two different tablets, that are taken orally.
For patients ages 6 to 11 years weighing less than 30 kg
The white tablet is marked with 'V50' and contains the medicines tezacaftor and ivacaftor. Take 1 white tablet in the morning.
The light blue tablet is marked with 'V 75' and contains the medicine ivacaftor. Take 1 light blue tablet in the evening.
For patients ages 6 to 11 years weighing more than 30 kg or ages 12 years and older
The yellow tablet is marked with 'V100' and contains the medicines tezacaftor and ivacaftor. Take 1 yellow tablet in the morning.
The light blue tablet is marked with 'V 150' and contains the medicine ivacaftor. Take 1 light blue tablet in the evening.
Take the morning tablet and the evening tablet about 12 hours apart.
Symdeko tablets should always be taken with food that contains fat. Fat helps the body absorb the medicine.
Examples of fat-containing foods include eggs, butter, peanut butter, cheese pizza, and whole-milk dairy products such as whole milk, cheese, and yogurt.
If you miss a dose of Symdeko and it is:
- 6 hours or less from the time you or your child usually takes the morning or evening dose:
Take the missed dose with fat-containing food as soon as possible. Then take the next dose at the usual time. - More than 6 hours from the time you or your child usually takes the morning or evening dose:
Do not take the missed dose. Take the next dose at the usual time with fat-containing food.
Do not take more than your usual dose of Symdeko to make up for a missed dose.
Read next
How does Symdeko work?
Symdeko contains ivacaftor and tezacaftor. Ivacaftor allows the defective CFTR protein to work better, improving the exchange of chloride ions across cell membranes within the airways. Tezacaftor moves the defective CFTR protein to the cell membrane so that it can facilitate the transfer of chloride ions across the membrane. Ivacaftor boost the function of the defective CFTR protein and tezacaftor corrects its location. This combined approach helps maintain a good balance of salt and water within the lungs and provides superior treatment compared to either drug alone. Continue reading
What is Fluimucil used for?
Fluimucil is a brand name for acetylcysteine sachets and tablets which may be used to clear phlegm and liquefy thick and viscous mucus secretions caused by respiratory conditions such as acute bronchitis, chronic bronchitis, cystic fibrosis, pneumonia, pulmonary emphysema, or bronchiectasis. It is a type of mucolytic. Fluimucil is available over the counter (without a prescription) in most countries that have it. Continue reading
What is Trikafta?
Trikafta is a triple combination therapy that contains elexacaftor, ivacaftor, and tezacaftor, which is approved for adults and children 2 years of age and older with at least one F508del mutation in the CFTR gene, or a mutation in the CFTR gene that is responsive to Trikafta based on clinical and/or laboratory data. Continue reading
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Related medical questions
- What is the difference between Symdeko and Orkambi?
- What is the difference between Symdeko and Kalydeco?
- How do the warnings differ between Symdeko and Orkambi?
- Can you take Symdeko with birth control pills?
- How does Kalydeco work?
- How do you take Orkambi?
Drug information
- Symdeko Information for Consumers
- Symdeko prescribing info & package insert (for Health Professionals)
- Side Effects of Symdeko (detailed)
Related support groups
- Symdeko (6 questions, 3 members)
- Cystic Fibrosis (10 questions, 29 members)