What is Trikafta?
Trikafta is a triple combination therapy that contains elexacaftor, ivacaftor, and tezacaftor, which is approved for adults and children 2 years of age and older with at least one F508del mutation in the CFTR gene, or a mutation in the CFTR gene that is responsive to Trikafta based on in vitro data.
This means it is suitable for over 90% of the cystic fibrosis population. Trikafta works by helping the protein made by the defective CFTR gene function more effectively. Common side effects include a rash, flu-like symptoms, headache, abdominal pain, nasal congestion, and diarrhea. Trikafta was approved in October 2019 and is made by Vertex Pharmaceuticals Incorporated
References
- FDA Approval history. Sep 13, 2023. https://www.drugs.com/history/trikafta.html
- Trikafta Prescribing Information. Aug, 20, 2023. https://www.drugs.com/pro/trikafta.html
Read next
What is Fluimucil used for?
Fluimucil is a brand name for acetylcysteine sachets and tablets which may be used to clear phlegm and liquefy thick and viscous mucus secretions caused by respiratory conditions such as acute bronchitis, chronic bronchitis, cystic fibrosis, pneumonia, pulmonary emphysema, or bronchiectasis. It is a type of mucolytic. Fluimucil is available over the counter (without a prescription) in most countries that have it. Continue reading
How does Kalydeco work?
Kalydeco specifically targets the underlying cause of cystic fibrosis (CF) and is approved for adults, children, and infants aged 4 months and older with CF with one or more specific mutations in their CFTR gene that is responsive to Kalydeco. It allows the defective CFTR protein to work better and increases salt and water movement within the airways. This thins the mucus and makes it easier to cough out. Continue reading
How does Symdeko work?
Symdeko contains ivacaftor and tezacaftor. Ivacaftor allows the defective CFTR protein to work better, improving the exchange of chloride ions across cell membranes within the airways. Tezacaftor moves the defective CFTR protein to the cell membrane so that it can facilitate the transfer of chloride ions across the membrane. Ivacaftor boost the function of the defective CFTR protein and tezacaftor corrects its location. This combined approach helps maintain a good balance of salt and water within the lungs and provides superior treatment compared to either drug alone. Continue reading
Related medical questions
- What is the difference between Symdeko and Orkambi?
- How do you take Orkambi?
- What is the difference between Symdeko and Kalydeco?
- How do the warnings differ between Symdeko and Orkambi?
- Can you take Symdeko with birth control pills?
- How are Symdeko tablets taken?
Drug information
Related support groups
- Trikafta (1 questions, 3 members)
- Elexacaftor/ivacaftor/tezacaftor (1 questions, 3 members)
- Cystic Fibrosis (10 questions, 29 members)