What is Reyvow used for and how does it work?
Reyvow (lasmiditan) is an oral prescription medicine used to treat acute migraine headaches in adults (with or without aura). Reyvow is not indicated for prevention of migraine. It is thought Reyvow works by binding and activating serotonin 5-HT(1F) receptors in the brain to help block pain signals involved with a migraine.
Reyvow is classified as an oral serotonin 5-HT(1F) receptor agonist, a newer class of drugs for the acute treatment of migraine. It is classified as a CV controlled substance in the U.S. because it contains lasmiditan, a target for people who abuse prescription medicines or street drugs.
Learn More: Is Reyvow a Controlled Substance by the DEA?
What is an aura?
An aura is an initial symptom, or group of symptoms, that may occur before or during a migraine, such as flashing lights or bright spots, a tingling sensation, trouble talking or hearing noises. Not everyone with a migraine has an aura.
Migraine symptoms can include:
- throbbing pain around the eyes and temples that can last for hours
- nausea
- vomiting
- blurred vision
- greater sensitivity to light and sound
- an aura
How fast does Reyvow work?
Reyvow has been shown to reduce or eliminate migraine pain and other symptoms in 2 hours when compared to a placebo in two placebo-controlled studies. In general, patients experienced 3 to 8 migraine headaches per month prior to enrollment in the studies.
In both studies, the number of patients achieving “pain freedom” and “freedom from the most bothersome symptom” (such as sensitivity to light, sensitivity to sound or nausea) 2 hours after treatment was significantly greater among patients receiving Reyvow at all doses compared to those receiving placebo.
- Pain freedom was defined as a reduction of moderate or severe headache pain to no pain at 2 hours. Freedom from the most bothersome symptom (MBS) was defined as the absence of the symptom (such as sensitivity to light, sensitivity to sound or nausea).
- In over 3,600 adults treated with one dose of Reyvow (50 mg, 100 mg, 200 mg) for a moderate or severe migraine headache, about 30% of people (30 out of every 100) were pain free within 2 hours compared to about 20% of people taking a placebo (a pill with no medicine).
- In over 3,300 adults, about 41% of people (41 out of every 100) were free from the most bothersome symptom (such as sensitivity to light, sensitivity to sound or nausea) at 2 hours compared to about 31% of people taking a placebo.
The most common side effects in studies were dizziness, fatigue, paresthesia (a skin tingling or numbness) and sedation (sleepiness).
It is taken at a dose of 50 mg, 100 mg, or 200 mg as needed for migraine (but no more than once per 24 hours). Follow your dosing instructions as prescribed by your doctor.
Reyvow can cause drowsiness. You should not drive or operate machinery until at least 8 hours after taking each dose of Reyvow. If you cannot wait at least 8 hours between taking a dose and driving or operating machinery, do not take this medicine.
This is not all the information you need to know about Reyvow (lasmiditan) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
Related questions
- What are the new drugs for the treatment of migraine?
- Is Reyvow a controlled substance?
- What are the side effects of beta blockers?
References
- Reyvow (lasmiditan). Prescribing information. Revised 9/2022. Eli Lilly and Company. Indianapolis, IN. Accessed Mar 7, 2023 at https://uspl.lilly.com/reyvow/reyvow.html#pi
- FDA Approves Reyvow (lasmiditan), the First Serotonin (5-HT) 1F Receptor Agonist for the Acute Treatment for Migraine. Drugs.com. Oct. 11, 2019 at https://www.drugs.com/newdrugs/fda-approves-reyvow-lasmiditan-first-serotonin-5-ht-1f-receptor-agonist-acute-migraine-5076.html
Read next
Why does throwing up relieve migraines?
For many, vomiting can help relieve migraine symptoms, even stopping the headache altogether. Research suggests that vomiting stops migraines by alleviating gastric stasis (or gastroparesis), the delayed gastric emptying that causes stomach upset to occur over the course of a migraine.
Continue reading
Do daith or tragus piercings help with migraines?
Daith and tragus piercings are popular mentions among online forums as unconventional treatment options for migraines. However, although some migraine patients say the piercings are an effective way to relieve migraine symptoms, there is no scientific evidence in support of these claims. Continue reading
Can depression cause headaches?
Yes, headaches can be a symptom of depression, among many other symptoms such as feeling sad, tearful and loss of interest in everyday activities. An association with depression has also been identified in patients with migraine headaches. Severe headaches may also cause a person to feel depressed. Continue reading
See also:
Aimovig
Learn about Aimovig (erenumab-aooe) a once-monthly, injectable medication that can be ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Vyepti
Vyepti (eptinezumab-jjmr) is used for the preventive treatment of migraine. Includes Vyepti ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Topamax
Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine ...
Emgality
Emgality (galcanezumab-gnlm) is a CGRP antagonist for the preventive treatment of migraine and for ...
Inderal
Inderal (propranolol) is used to treat angina, high blood pressure and heart rhythm disorders ...
Ajovy
Ajovy (fremanezumab-vfrm) is a preventive migraine treatment. Includes Ajovy side effects ...
Valproate Sodium
Valproate Sodium is used for epilepsy, seizure prevention, seizures
Related medical questions
- What are the side effects of the flu vaccine?
- What causes optical migraines?
- Headache or Migraine: Which one is it?
- What is a migraine aura?
- How does Aimovig work to prevent migraines?
- How long do venlafaxine withdrawal symptoms last?
- How do Celebrex and ibuprofen compare?
- Can ibuprofen cause constipation?
- Can you take ibuprofen with Excedrin Migraine?
- Is gabapentin addictive?
- Should gabapentin be taken with food?
- How do Ubrelvy, Qulipta and Nurtec compare for migraines?
- How often can you take Excedrin Migraine?
- How many units of Botox do I need and what will it cost?
- Can you take Excedrin Migraine while pregnant?
- How long do you stay on Topamax for migraines?
- How often can you take Imitrex (sumatriptan)?
- Does magnesium help with headaches and migraines?
- How long does it take for Topamax to start working?
- Dysport vs Botox: What's the difference?
- How long does it take for Excedrin Migraine to work?
- Ubrelvy Coupon Card: Do I Qualify, and How Much Can I Save?
- Nurtec coupon: Do I qualify and how much can I save?
- Does Qulipta cause weight loss?
- Ubrelvy vs Imitrex (sumatriptan): How do they compare?
Drug information
- Reyvow Information for Consumers
- Reyvow prescribing info & package insert (for Health Professionals)
- Side Effects of Reyvow (detailed)
- Reyvow user reviews (23)