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What drugs should you avoid with Ehlers-Danlos syndrome?

Medically reviewed by Sally Chao, MD. Last updated on June 27, 2023.

Official answer


With Ehlers-Danlos syndrome (EDS), experts recommend avoiding drugs that increase your risk of bleeding—such as anticoagulants and antiplatelet agents—because those affected with EDS are at higher risk for bruising and injury. The Food and Drug Administration (FDA) also recommends avoiding fluoroquinolone antibiotics if you have EDS because of an association of this class of medication with the occurrence of aneurysm.

EDS is a group of inheritable disorders that affect connective tissue. It causes an abnormality in the structure, development or processing of collagen. Collagen is the main component in your connective tissue and is found in your joints, ligaments, skin and blood vessels. EDS is caused by mutations or errors in the genes that code for collagen production.

There are currently 13 recognized subtypes of EDS. Symptoms of EDS vary according to subtype and can affect many different organs. Common symptoms include:

  • Easy bruising
  • Poor wound healing
  • Soft, stretchy skin
  • Joint hyperflexibility
  • Bone or muscle pain
  • Fragile blood vessels and internal organs

EDS can cause significant disability. Patients may see various health care providers, including orthopedists, physical therapists, dermatologists or rheumatologists, depending on symptoms. There is no cure for EDS.

Treatment varies according to the severity and subtype of EDS involved. The focus of treatment is placed on relief of symptoms and prevention of complications. Medications such as pain relievers and non-drug therapies such as massage or biofeedback may be used for symptom control.

Patients are discouraged from taking part in activities such as sports that could result in tissue injury, and surgical procedures are avoided as much as possible.

  1. Genetic and Rare Diseases Information Center. Ehlers-Danlos Syndrome. April 20, 2017. Available at: [Accessed May 25, 2021].
  2. Arthritis Foundation. Ehlers-Danlos Syndrome. Available at: [Accessed May 25, 2021].
  3. Islam M, Chang C, Gershwin ME. Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons. Journal of Translational Autoimmunity. 2021;4,100077.
  4. U.S. Food and Drug Administration (FDA). Drug Safety Communications FDA warns about increased risk of ruptures or tears in the aorta blood vessel with

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