How does Botox (botulinum toxin) work?
There are eight different types of botulinum toxin produced by C. botulinum; A, B, C1, C2, D, E, F, and G. All work by blocking the release of acetylcholine, one of the most significant neurotransmitters in our body. Acetylcholine activates muscles, so blocking it causes muscle relaxation and paralysis. Injections enable the botulinum toxin to be targeted directly into specific muscles. There it has a direct effect on acetylcholine in the nerve synapses, preventing signals that would normally cause the muscle to contract.
Type A is the most potent and longest lasting, followed by types B and F. Currently, preparations containing Type A and B are commercially available and include:
- OnabotulinumtoxinA (Botox, Botox Cosmetic)
- AbobotulinumtoxinA (Dysport)
- IncobotulinumtoxinA (Xeomin)
- LetibotulinumtoxinA-wlbg (Letybo)
- PrabotulinumtoxinA-xvfs (Jeuveau)
- RimabotulinumtoxinB (Myobloc).
All have different potencies and are not interchangeable; care needs to be taken so that the correct dosage stated is used for that product. Each manufacturer uses assay methods specific to their company, so even though dosages may be quoted in similar sounding units, potency varies several-fold between the different products. Approved indications also vary.
Effects are usually seen within 24-72 hours and peak around ten days. Effects last about two to four months or until new nerve terminals sprout and form new synaptic contacts.
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Masseter Botox for Jaw Slimming: Benefits, Cost, Side Effects & Results
Masseter Botox is a cosmetic and therapeutic procedure where botulinum toxin injections (such as Botox) are administered directly into the masseter muscles – the powerful chewing muscles located on each side of your face. This jaw Botox treatment has gained popularity for TMJ relief, teeth grinding (also called bruxism), and facial contouring.
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How many units of Botox do I need and what will it cost?
Botox (onabotulinumtoxinA) is measured in units, and the number of units you need depends on the treatment area, muscle strength, and your goals. Most providers charge $10–$25 per unit in the U.S.
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Where do they inject Botox for migraines?
Botox is injected into 7 specific muscle areas around your head and neck to help prevent migraine headaches before they start. Areas include your forehead, bridge of the nose, temples, neck, back of the head, and just above the shoulder blades in your upper back. Continue reading
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Drug information
- Botox Information for Consumers
- Botox prescribing info & package insert (for Health Professionals)
- Side Effects of Botox (detailed)
- Botox user reviews (481)
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