What is Daxxify, the recent FDA-alternative to Botox?
Daxxify (daxibotulinumtoxinA-lanm) is the first Botox alternative that is free of human albumin or animal-based components, and it was FDA-approved in September 2022. It is also the longest-lasting of all the cosmetic injectable wrinkle treatments, lasting for 6 months in most people and 9 months in some. Daxxify is made by Revance Therapeutics Inc., and the formulation uses a patented, innovative, cell-penetrating peptide technology (called Peptide Exchange Technology) consisting of a man-made 35-amino acid stabilizing excipient with a highly positive charge.
Although Daxxify lasts longer than Botox it is only currently approved to treat glabella lines and adults with cervical dystonia (a rare muscle disorder that causes neck spasms and twisting). Botox Cosmetic has approval to treat frown lines, crow’s feet lines, and forehead lines, and Botox has approval to treat several medical conditions like chronic migraines, specific bladder issues, excessive sweating, and other muscle-related problems.
How often does Daxxify need to be injected?
Daxxify only needs two treatments a year to give year-long results, because the average duration of effect is six months. In some people, Daxxify lasts for 9 months. Botox only lasts for 3 to 4 months.
Clinical trials reported that 80 percent of people using Daxxify had no or minimally visible facial wrinkles after four months, with approximately 50% with little evidence of wrinkles at six months.
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What is Daxxify FDA-approved for?
Currently, Daxxify is only FDA-approved to treat glabella lines – the short vertical skin lines that appear between the eyebrows and above the nose. These are usually the first wrinkles to appear on the forehead.
What is the recommended dosage for Daxxify?
Daxxify is usually given as 5 equal intramuscular injections of 8 units each (two injections into each corrugator muscle and one into the procerus muscle) for a total recommended dose of 40 units.
What are the most common side effects of Daxxify?
The most commonly observed adverse reactions reported with Daxiffy are:
- headache (6%)
- eyelid drooping (2%)
- and facial asymmetry(1%).
What does Daxxify cost?
Because Daxxify lasts longer it is likely to cost around 50% more than what you are currently paying for Botox, depending on your provider and where you are located. So, if your current cost for a Botox treatment sits between $300 and $600, expect to pay around $450 to $900 for Daxxify treatment.
How does Daxxify work?
Daxxify works similarly to Botox, and that is by preventing the release of acetylcholine by blocking cholinergic transmission at the neuromuscular junction. The critical difference between Daxxify and Botox is that Daxxify has been formulated with a proprietary stabilizing excipient peptide called RTP004, instead of serum albumin. This has been shown to enhance the binding of Daxxify to the nerve surface which enhances how much is taken up by the nerve, increasing the length of time it works for.
References
- Daxxify (daxibotulinumtoxinA-lanm) Updated Aug 23, 202s. Revance Therapeutics Inc. https://www.drugs.com/pro/daxxify.html
- Revance Announces FDA Approval of DAXXIFY™ (DaxibotulinumtoxinA-lanm) for Injection, the First and Only Peptide-Formulated Neuromodulator With Long-Lasting Results September 08, 2022. Revance. https://investors.revance.com/news-releases/news-release-details/revance-announces-fda-approval-daxxifytm-daxibotulinumtoxina
- Daxxify, a New Botox Alternative That Was Just Approved by the FDA. Sept 23, 2022 Self. https://www.self.com/story/daxxify-new-botox-alternative
- Ries Julia. Meet Daxxify, a New Botox Alternative That Was Just Approved by the FDA. Sept 23, 2022 Self. https://www.self.com/story/daxxify-new-botox-alternative
- Solish, N., Carruthers, J., Kaufman, J., Rubio, R. G., Gross, T. M., & Gallagher, C. J. (2021). Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A. Drugs, 81(18), 2091–2101. https://doi.org/10.1007/s40265-021-01631-w
- Daxxify Product Label Sept 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/761127s000lbl.pdf
Read next
Does Botox for migraines also help with wrinkles?
Botox Cosmetic is used for aesthetic purposes for wrinkles and Botox is used as a therapeutic treatment for different medical conditions, including migraine headache prevention. Botox Cosmetic and Botox come as separate products but are both prescription medicines that contain the active ingredient onabotulinumtoxinA. Continue reading
Daxxify vs Botox: Which should you use?
Both Daxxify (daxibotulinumtoxinA-lanm) and Botox (onabotulinumtoxinA) are effective neuromodulators derived from botulinum toxin type A, designed to smooth dynamic wrinkles. Botox offers a long-established track record with results typically lasting 3-4 months. Daxxify represents a newer innovation, distinguished primarily by its longer duration of effect, often lasting 6 months or more, thanks to its unique peptide stabilizer.
Continue reading
How much does Botox cost?
The cash price for Botox is around $677 to $1,344 for a 100 or 200 unit vial, but you will not pay this price. Most people (80%) pay $0 and may save money on the injection procedure with the Botox Savings Program offered through AbbVie, the manufacturer of Botox. Continue reading
See also:
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