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Generic name: inclisiran
Dosage form: subcutaneous injection (284 mg/1.5 mL)
Drug class: Miscellaneous antihyperlipidemic agents

Medically reviewed by Melisa Puckey, BPharm. Last updated on Sep 3, 2023.

What is Leqvio?

Leqvio (inclisiran) is a prescription medicine used to lower LDL-C cholesterol levels for adults with certain types of high cholesterol (primary hyperlipidemia). Leqvio reduces ‘bad’ low-density lipoprotein cholesterol (LDL-C) and is used with diet and statin therapy. 

Leqvio works by blocking a protein in the liver, this increases  LDL-C clearance, which lowers the amount of 'bad' cholesterol in your blood. The protein it blocks is proprotein convertase subtilisin kexin type 9 (PCSK9). Leqvio is a small interfering RNA (siRNA) and was the first medication of its class to be approved to lower 'bad' LDL cholesterol. 

Leqvio is given as an injection under the skin (subcutaneous) as a first dose, then a second dose at 3 months, and then every 6 months after that.

What is Leqvio used for?

Leqvio is indicated for adults with primary hyperlipidemia, which is high cholesterol due to genetic abnormalities, including heterozygous familial hypercholesterolemia (HeFH). Leqvio should be used together with statin therapy and diet.

Leqvio originally received FDA approval on December 22, 2021, and the indications were expanded on July 10, 2023.

Leqvio side effects

Common Leqvio side effects

Serious Leqvio side effects

Get emergency medical help if you have signs of an allergic reaction: hives, severe itching, difficulty breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking this medicine

Do not receive this medicine if you are allergic to the active ingredient inclisiran or inactive ingredients in this medication. See below for a complete list of ingredients.

Tell your doctor if you use other medicines or have other medical conditions, including severe kidney disease, are receiving dialysis, or have severe liver disease.

You should not have this injection if you are under 18 years of age.


Tell your doctor if you are pregnant, become pregnant, or plan to become pregnant. The use of this medicine should be avoided during pregnancy.


Tell your doctor if you are breastfeeding or plan to breastfeed. It is not yet known whether this medicine passes into human breast milk. Your doctor will consider the potential benefits of treatment for you and the risks to your baby compared to the risks of breastfeeding for your baby.

How should I receive Leqvio?

Dosing information

The recommended dosage of Leqvio:

Leqvio is available in a single-dose prefilled syringe 284 mg/1.5 mL (189 mg/mL). 

Inclisiran is only part of a complete treatment program that includes diet, statin medication, and regular blood testing.

What happens if I miss a dose?

If you miss a dose of this medicine and it has been less than 3 months, then see your healthcare provider for a dose and continue with your original dosing schedule.

If you miss a dose of this medicine and it has been more than 3 months, then see your healthcare provider and restart with a new dosing schedule - starting with an initial dose, then another dose at 3 months, and then every 6 months after that.

What happens if I overdose?

There is no specific treatment for an overdose of this medicine If you receive too much, your healthcare provider will check you for side effects and treat any side effects as required.


Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Leqvio is not expected to cause drug-drug interactions or to be affected by inhibitors or inducers of cytochrome P450 enzymes or transporters.



Active ingredient: inclisiran sodium

Inactive ingredients: water, sodium hydroxide, phosphoric acid

Contains no preservatives. Not made with natural rubber latex.


Manufactured by: Sandoz GmbH, Langkarnpfen, Austria.

Distributed by: Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936.

Popular FAQ

Leqvio and Repatha are both injectable medicines that are used for the treatment of high cholesterol, by specifically lowering low density lipoprotein (LDL) levels. Although they both inhibit PCSK9 they work by different mechanisms. Repatha is a monoclonal antibody that binds directly to PCSK9 in the liver preventing it from binding to LDL receptors. Leqvio blocks the PCSK9 protein by interfering with the translation of PCSK9 messenger RNA. Both have the same result – and that is freeing up LDL receptors on the surface of liver cells which allows LDL cholesterol to be removed from the blood. Continue reading

The PCSK9 inhibitors are used for the treatment of high-risk patients with elevated cholesterol, especially when statins aren't adequate. They work by blocking PCSK9, leaving more receptors available to capture your "bad" cholesterol (LDL) for break down and removal from the blood. Continue reading

Leqvio may be used alone or with other medications, such as statins, to treat high cholesterol, in addition to a heart-healthy diet. But it can be prescribed without a statin if statins are not tolerated or contraindicated. Continue reading

Weight gain is not reported as a side effect of Leqvio in the product information and neither does it seem to be a topic of discussion on blog sites. Weight gain has also not been reported with other PCSK9 inhibitors, such as Repatha. Continue reading

Leqvio is administered subcutaneously, which means just under the skin. Your healthcare provider will sit or lie you down and then inject Leqvio just under the skin of your abdomen, upper arm, or thigh. This may cause slight pain and redness around the site of the injection. You cannot administer Leqvio yourself. Continue reading

Leqvio works by blocking production of the PCSK9 protein which means more LDL receptors are present on liver cells which increases the uptake of LDL cholesterol and lowers LDL cholesterol in the blood, reducing cholesterol levels. Continue reading

Leqvio is FDA approved as a high-cholesterol treatment and it specifically lowers LDL cholesterol levels (sometimes referred to as "bad" cholesterol. It is approved for people with atherosclerosis (hardening and narrowing of the arteries caused by a build-up of fatty plaques) or heterozygous familial hypercholesterolemia (a genetic condition that causes high levels of LDL cholesterol). Leqvio may be prescribed alone or in addition to statins or other cholesterol-lowering medications. Continue reading

The actor in the Leqvio commercial "Forging on" is Robert Leardi an actor who was born in Southington, Connecticut, USA on 4 November 1961. He has also played Lt. Schrank in the 2008 production of West Side Story in London’s West End and performed in several TV series such as The Thing (2012) and Ladies Revenge Club (2014). Continue reading

You can find the Leqvio FDA package insert on the FDA Access Data website, or read the prescribing information for Leqvio that has been published by which is derived from the product information. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.