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Levomefolic Acid



CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories

Treatment and prevention of folate deficiency

Antidote against folic acid antagonists

Chemical Name

N-(4{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methylamino}benzoyl)-L-glutamic acid (WHO)

Foreign Names

  • Acidum levomefolicum (Latin)
  • Levomefolinsäure (German)
  • Acide lévoméfolique (French)
  • Acido levomefolico (Spanish)

Generic Names

  • Levomefolic Acid (OS: USAN)
  • (6S)-5-methyltetrahydrofolate (IS)
  • (6S)-5-MTHF (IS)
  • 5-methyltetrahydrofolate (IS)
  • 5-MTHF (IS)
  • Levomefolinic Acid (IS)
  • Levomefolinsäure (IS)
  • L-methylfolate (IS)
  • Mefolinsäure (IS)
  • UNII-8S95DH25XC (IS)
  • Levomefolate Calcium (OS: USAN)
  • Levomefolinate Calcium (OS)
  • 5-MTHF, Calciumsalt (IS)
  • BAY 86-7660 (IS)
  • Calcium L-methylfolate (IS)
  • Calcium L-methyltetrahydrofolate (IS)
  • Calcium mefolinate (IS)
  • LMCA (IS)
  • UNII-A9R10K3F2F (IS)
  • Calcium L-5-Methyltetrahydrofolate (PH: USP 38)

Brand Names

  • Biofolic
    Delvin, India
  • Femelle Fol (Levomefolic Acid and Ethinylestradiol, + Drospirenone)
    Gynopharm, Chile
  • Poli-Vi-Flor (Levomefolic Acid and Fluoride)
    Zylera, United States
  • Poly-Vi-Flor (Levomefolic Acid and Sodium Fluoride)
    Zylera, United States
  • Vitalin
    Molekule, India
  • Folsyn
    Basic, Philippines
  • Lifodep Plus (Levomefolic Acid and Escitalopram)
    Molekule, India
  • New Lifodep
    Molekule, India
  • Prefolic
    Zambon, Italy
  • Yaz Plus (Levomefolic Acid and Drospirenone, + Ethinylestradiol)
    Bayer, Canada; Bayer HealthCare, Russian Federation


ISInofficial Synonym
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.